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Entry version 121 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Probable protein phosphatase 2C 33

Gene

PPC6-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi100Manganese 1By similarity1
Metal bindingi100Manganese 2By similarity1
Metal bindingi101Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi338Manganese 2By similarity1
Metal bindingi384Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable protein phosphatase 2C 33 (EC:3.1.3.16)
Short name:
AtPP2C33
Alternative name(s):
AtPPC6;1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPC6-1
Ordered Locus Names:At3g02750
ORF Names:F13E7.31
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G02750

The Arabidopsis Information Resource

More...
TAIRi
locus:2075487 AT3G02750

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003679601 – 492Probable protein phosphatase 2C 33Add BLAST492

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9M8R7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9M8R7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9M8R7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M8R7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M8R7 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
6243, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9M8R7, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9M8R7

STRING: functional protein association networks

More...
STRINGi
3702.AT3G02750.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9M8R7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 393PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST330

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233897

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9M8R7

Identification of Orthologs from Complete Genome Data

More...
OMAi
DIDCFCS

Database of Orthologous Groups

More...
OrthoDBi
1344250at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M8R7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00143 PP2Cc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13832 PTHR13832, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00481 PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00332 PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81606 SSF81606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51746 PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9M8R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSCLSAESR SPRPGSPCSP AFSVRKRKNS KKRPGSRNSS FDYRREEPLN
60 70 80 90 100
QVPGRMFLNG STEVACIYTQ QGKKGPNQDA MVVWENFGSR TDTIFCGVFD
110 120 130 140 150
GHGPYGHMVA KRVRDNLPLK LSAYWEAKVP VEGVLKAITT DTVNNVTNIN
160 170 180 190 200
NPEDAAAAAA FVTAEEEPRT SADMEEENTE TQPELFQTLK ESFLKAFKVM
210 220 230 240 250
DRELKFHGSV DCFCSGTTAV TLIKQGQYLV VGNVGDSRAV MGTRDSENTL
260 270 280 290 300
VAVQLTVDLK PNLPAEAERI RKCRGRVFAL RDEPEVCRVW LPNCDSPGLA
310 320 330 340 350
MARAFGDFCL KDFGLISVPD VSFRQLTEKD EFIVLATDGI WDVLSNEDVV
360 370 380 390 400
AIVASAPSRS SAARALVESA VRAWRYKYPT SKVDDCAAVC LYLDSSNTNA
410 420 430 440 450
ISTASSISKL EDGEEEELKA TTEDDDASGP SGLGRSSTVR SGKEIALDES
460 470 480 490
ETEKLIKEAD NLDSEPGTEY SALEGVARVN TLLNLPRFVP GK
Length:492
Mass (Da):53,715
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD021BD5ACE735CF2
GO
Isoform 2 (identifier: Q9M8R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-264: P → PGWIILCECMMLSCGCMMDPLIMFIGFFFIPSIELA

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:527
Mass (Da):57,674
Checksum:iE6296601474665D8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BX824075 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41F → L in AAL32574 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036766264P → PGWIILCECMMLSCGCMMDP LIMFIGFFFIPSIELA in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC018363 Genomic DNA Translation: AAF26985.1
CP002686 Genomic DNA Translation: AEE73854.1
CP002686 Genomic DNA Translation: AEE73855.1
CP002686 Genomic DNA Translation: AEE73856.1
AY062496 mRNA Translation: AAL32574.1
BX824075 mRNA No translation available.
BT020578 mRNA Translation: AAW80851.1
BT029026 mRNA Translation: ABI93935.1
AB079669 mRNA Translation: BAB84698.1

NCBI Reference Sequences

More...
RefSeqi
NP_001030624.1, NM_001035547.2 [Q9M8R7-1]
NP_001030625.1, NM_001035548.1 [Q9M8R7-2]
NP_186924.1, NM_111143.3 [Q9M8R7-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G02750.1; AT3G02750.1; AT3G02750 [Q9M8R7-1]
AT3G02750.2; AT3G02750.2; AT3G02750 [Q9M8R7-1]
AT3G02750.3; AT3G02750.3; AT3G02750 [Q9M8R7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
820909

Gramene; a comparative resource for plants

More...
Gramenei
AT3G02750.1; AT3G02750.1; AT3G02750 [Q9M8R7-1]
AT3G02750.2; AT3G02750.2; AT3G02750 [Q9M8R7-1]
AT3G02750.3; AT3G02750.3; AT3G02750 [Q9M8R7-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G02750

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018363 Genomic DNA Translation: AAF26985.1
CP002686 Genomic DNA Translation: AEE73854.1
CP002686 Genomic DNA Translation: AEE73855.1
CP002686 Genomic DNA Translation: AEE73856.1
AY062496 mRNA Translation: AAL32574.1
BX824075 mRNA No translation available.
BT020578 mRNA Translation: AAW80851.1
BT029026 mRNA Translation: ABI93935.1
AB079669 mRNA Translation: BAB84698.1
RefSeqiNP_001030624.1, NM_001035547.2 [Q9M8R7-1]
NP_001030625.1, NM_001035548.1 [Q9M8R7-2]
NP_186924.1, NM_111143.3 [Q9M8R7-1]

3D structure databases

SMRiQ9M8R7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi6243, 1 interactor
IntActiQ9M8R7, 1 interactor
MINTiQ9M8R7
STRINGi3702.AT3G02750.3

PTM databases

iPTMnetiQ9M8R7
SwissPalmiQ9M8R7

Proteomic databases

PRIDEiQ9M8R7

Genome annotation databases

EnsemblPlantsiAT3G02750.1; AT3G02750.1; AT3G02750 [Q9M8R7-1]
AT3G02750.2; AT3G02750.2; AT3G02750 [Q9M8R7-1]
AT3G02750.3; AT3G02750.3; AT3G02750 [Q9M8R7-2]
GeneIDi820909
GrameneiAT3G02750.1; AT3G02750.1; AT3G02750 [Q9M8R7-1]
AT3G02750.2; AT3G02750.2; AT3G02750 [Q9M8R7-1]
AT3G02750.3; AT3G02750.3; AT3G02750 [Q9M8R7-2]
KEGGiath:AT3G02750

Organism-specific databases

AraportiAT3G02750
TAIRilocus:2075487 AT3G02750

Phylogenomic databases

HOGENOMiHOG000233897
InParanoidiQ9M8R7
OMAiDIDCFCS
OrthoDBi1344250at2759
PhylomeDBiQ9M8R7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9M8R7

Gene expression databases

ExpressionAtlasiQ9M8R7 baseline and differential
GenevisibleiQ9M8R7 AT

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2C33_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M8R7
Secondary accession number(s): Q2V3Z1, Q8SBC3, Q8W4L2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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