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UniProtKB - Q9M7Q7 (PCNA1_ARATH)
Protein
Proliferating cellular nuclear antigen 1
Gene
PCNA
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 61 – 80 | Sequence analysisAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA polymerase processivity factor activity Source: GO_Central
GO - Biological processi
- leading strand elongation Source: GO_Central
- mismatch repair Source: GO_Central
- regulation of cell cycle Source: TAIR
- regulation of DNA replication Source: InterPro
- translesion synthesis Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA replication |
Names & Taxonomyi
Protein namesi | Recommended name: Proliferating cellular nuclear antigen 1Short name: PCNA 1 |
Gene namesi | Name:PCNA Synonyms:PCNA1 Ordered Locus Names:At1g07370 ORF Names:F22G5.29 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G07370 |
TAIRi | locus:2025062, AT1G07370 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: TAIR
Nucleus
- nucleolus Source: TAIR
- nucleus Source: TAIR
- PCNA complex Source: GO_Central
Other locations
- cytoplasm Source: TAIR
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149177 | 1 – 263 | Proliferating cellular nuclear antigen 1Add BLAST | 263 |
Proteomic databases
PaxDbi | Q9M7Q7 |
PRIDEi | Q9M7Q7 |
ProteomicsDBi | 236846 |
PTM databases
iPTMneti | Q9M7Q7 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9M7Q7, baseline and differential |
Genevisiblei | Q9M7Q7, AT |
Interactioni
Subunit structurei
Homo- and heterotrimer.
Interacts with POLH, ATXR5 and ATXR6.
3 PublicationsBinary interactionsi
Q9M7Q7
With | #Exp. | IntAct |
---|---|---|
POLH [Q8H2D5] | 2 | EBI-1810458,EBI-1810451 |
Protein-protein interaction databases
BioGRIDi | 22490, 46 interactors |
IntActi | Q9M7Q7, 7 interactors |
STRINGi | 3702.AT1G07370.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9M7Q7 |
SMRi | Q9M7Q7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9M7Q7 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PCNA family.Curated
Phylogenomic databases
eggNOGi | KOG1636, Eukaryota |
HOGENOMi | CLU_043978_3_0_1 |
InParanoidi | Q9M7Q7 |
OMAi | EMKLINM |
OrthoDBi | 1012066at2759 |
PhylomeDBi | Q9M7Q7 |
Family and domain databases
HAMAPi | MF_00317, DNApol_clamp_arch, 1 hit |
IDEALi | IID50102 |
InterProi | View protein in InterPro IPR000730, Pr_cel_nuc_antig IPR022649, Pr_cel_nuc_antig_C IPR022659, Pr_cel_nuc_antig_CS IPR022648, Pr_cel_nuc_antig_N |
Pfami | View protein in Pfam PF02747, PCNA_C, 1 hit PF00705, PCNA_N, 1 hit |
PRINTSi | PR00339, PCNACYCLIN |
TIGRFAMsi | TIGR00590, pcna, 1 hit |
PROSITEi | View protein in PROSITE PS01251, PCNA_1, 1 hit PS00293, PCNA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9M7Q7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLELRLVQGS LLKKVLESIK DLVNDANFDC SSTGFSLQAM DSSHVALVSL
60 70 80 90 100
LLRSEGFEHY RCDRNLSMGM NLGNMSKMLK CAGNDDIITI KADDGGDTVT
110 120 130 140 150
FMFESPTQDK IADFEMKLMD IDSEHLGIPD AEYHSIVRMP SNEFSRICKD
160 170 180 190 200
LSSIGDTVVI SVTKEGVKFS TAGDIGTANI VLRQNTTVDK PEDAIVIEMK
210 220 230 240 250
EPVSLSFALR YMNSFTKATP LSDTVTISLS SELPVVVEYK VAEMGYIRYY
260
LAPKIEEEED TNP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | V → A in AAF40018 (Ref. 1) Curated | 1 | |
Sequence conflicti | 48 | V → A in ABU25233 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF083220 mRNA Translation: AAF40018.1 EU072917 mRNA Translation: ABU25233.1 AC022464 Genomic DNA Translation: AAF79566.1 CP002684 Genomic DNA Translation: AEE28115.1 AF462821 mRNA Translation: AAL58911.1 AY098969 mRNA Translation: AAM19979.1 AY086852 mRNA Translation: AAM63900.1 |
RefSeqi | NP_172217.1, NM_100611.4 |
Genome annotation databases
EnsemblPlantsi | AT1G07370.1; AT1G07370.1; AT1G07370 |
GeneIDi | 837249 |
Gramenei | AT1G07370.1; AT1G07370.1; AT1G07370 |
KEGGi | ath:AT1G07370 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF083220 mRNA Translation: AAF40018.1 EU072917 mRNA Translation: ABU25233.1 AC022464 Genomic DNA Translation: AAF79566.1 CP002684 Genomic DNA Translation: AEE28115.1 AF462821 mRNA Translation: AAL58911.1 AY098969 mRNA Translation: AAM19979.1 AY086852 mRNA Translation: AAM63900.1 |
RefSeqi | NP_172217.1, NM_100611.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ZVV | X-ray | 2.00 | A/B | 1-256 | [»] | |
6O09 | X-ray | 2.06 | A/C/D/F/H/K | 1-263 | [»] | |
AlphaFoldDBi | Q9M7Q7 | |||||
SMRi | Q9M7Q7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 22490, 46 interactors |
IntActi | Q9M7Q7, 7 interactors |
STRINGi | 3702.AT1G07370.1 |
PTM databases
iPTMneti | Q9M7Q7 |
Proteomic databases
PaxDbi | Q9M7Q7 |
PRIDEi | Q9M7Q7 |
ProteomicsDBi | 236846 |
Genome annotation databases
EnsemblPlantsi | AT1G07370.1; AT1G07370.1; AT1G07370 |
GeneIDi | 837249 |
Gramenei | AT1G07370.1; AT1G07370.1; AT1G07370 |
KEGGi | ath:AT1G07370 |
Organism-specific databases
Araporti | AT1G07370 |
TAIRi | locus:2025062, AT1G07370 |
Phylogenomic databases
eggNOGi | KOG1636, Eukaryota |
HOGENOMi | CLU_043978_3_0_1 |
InParanoidi | Q9M7Q7 |
OMAi | EMKLINM |
OrthoDBi | 1012066at2759 |
PhylomeDBi | Q9M7Q7 |
Miscellaneous databases
EvolutionaryTracei | Q9M7Q7 |
PROi | PR:Q9M7Q7 |
Gene expression databases
ExpressionAtlasi | Q9M7Q7, baseline and differential |
Genevisiblei | Q9M7Q7, AT |
Family and domain databases
HAMAPi | MF_00317, DNApol_clamp_arch, 1 hit |
IDEALi | IID50102 |
InterProi | View protein in InterPro IPR000730, Pr_cel_nuc_antig IPR022649, Pr_cel_nuc_antig_C IPR022659, Pr_cel_nuc_antig_CS IPR022648, Pr_cel_nuc_antig_N |
Pfami | View protein in Pfam PF02747, PCNA_C, 1 hit PF00705, PCNA_N, 1 hit |
PRINTSi | PR00339, PCNACYCLIN |
TIGRFAMsi | TIGR00590, pcna, 1 hit |
PROSITEi | View protein in PROSITE PS01251, PCNA_1, 1 hit PS00293, PCNA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PCNA1_ARATH | |
Accessioni | Q9M7Q7Primary (citable) accession number: Q9M7Q7 Secondary accession number(s): A7UIK5, Q9LNV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | February 21, 2001 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families