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Entry version 132 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Serine/threonine-protein kinase ATM

Gene

ATM

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR) or DNA replication stalling. Plays a central role in the perception and response to both stress-induced damage in somatic cells and developmentally programmed DNA damage during meiosis. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Involved in transcriptional regulation of RAD51, PARP1, GR1, and LIG4 in response to DNA double strand breaks. Plays a dual role by activating the DNA damage response at dysfunctional telomeres and yet preventing this activation at functional telomeres. Not required for telomere length homeostasis. Regulates DNA damage response (DDR) synergistically with RUG3. Together with RUG3, involved in the splicing of the ND2/NAD2 mRNA (PubMed:28262819).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, DNA damage, Meiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT3G48190-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase ATM1 Publication (EC:2.7.11.1)
Alternative name(s):
Ataxia telangiectasia mutated homolog1 Publication
Short name:
AtATM1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATM1 Publication
Ordered Locus Names:At3g48190Imported
ORF Names:T24C20.70Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G48190

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Plants show meiotic defects, hypersensitivity to double strand breaks-inducing agents, and an inability to properly induce IR-mediated transcription of several DNA repair genes. Augmented DNA damage response (DDR) associated with increased intracellular reactive oxygen species (ROS) levels in response to methyl methanesulfonate (MMS) treatment (PubMed:28262819).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888431 – 3856Serine/threonine-protein kinase ATMAdd BLAST3856

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9M3G7

PRoteomics IDEntifications database

More...
PRIDEi
Q9M3G7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed at low levels with slightly higher levels in flower buds.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M3G7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M3G7 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RUG3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
9294, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G48190.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 162PWWPPROSITE-ProRule annotationAdd BLAST55
Domaini2727 – 3393FATPROSITE-ProRule annotationAdd BLAST667
Domaini3525 – 3773PI3K/PI4KPROSITE-ProRule annotationAdd BLAST249
Domaini3824 – 3856FATCPROSITE-ProRule annotationAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3233 – 3249Bipartite nuclear localization signalSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0892 Eukaryota
ENOG410XNPY LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9M3G7

Database of Orthologous Groups

More...
OrthoDBi
80538at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M3G7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR038980 ATM_plant
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR000313 PWWP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR37079 PTHR37079, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00855 PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS50812 PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9M3G7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLQNPDKKT LREGFSQESS VVALDSGVLA MSGLKCDGKF PVKDVLMEEG
60 70 80 90 100
GDKVRKIQVS GGNISLVVDF SGARTSSNNF FESNASCVNE NLVKGNGYRE
110 120 130 140 150
DETQEFLVGN LVWVMTKYKK WWPGEVVDFK ADAKESFMVR SIGQSHLVSW
160 170 180 190 200
FASSKLKPFK ESFEQVLNQR NDNGFFDALQ KAMSLLSNSL KLDMTCSCIA
210 220 230 240 250
DGNGIVSAQN ITTRKNKPLI LREFSVDRLE PKEFVTQLKN IAKCVLNAGV
260 270 280 290 300
LESTVMQSQL SAFYTLFGHK QIPMAQLHEN EGRKSFTAKM SDSKFIGSPS
310 320 330 340 350
ICAGNSRKRF RKEWFRKFVS EVDNVSARDD LVNVPPSDLI SKLKLLAVGY
360 370 380 390 400
NCSEETENIG LFEWFFSKFR ISVYHDENAY KMQLANMAGF KDLMLATNAN
410 420 430 440 450
RGTVQKTLKS KKIGKSKMEP LNGVSVADTE QKTFELQISK KSNIESLNGV
460 470 480 490 500
SVADTEQKTF ELQILEKSNI ESLNGVSTPN IDHEASKSNN SGKTKINHII
510 520 530 540 550
GHSNFPSSVA KVQLAKDFQD KLLVQAPDRK AMTADTLSRP AAILVPDLNS
560 570 580 590 600
GGNALGTAEF DHMQRPETLI QHNVCPQEEK TPRSTILNFQ VTAHQGVSGT
610 620 630 640 650
QFVSSQPTSY KHFTSADLFT YSGKKKRGRK RKNAEELPIV AHASATTGIP
660 670 680 690 700
DLNGTNTEPT LVLPQVEPTQ RRRRRKKEES PNGLTRGITI LFLKFSSQVS
710 720 730 740 750
MPSRDDLTST FSAFGPLDSS ETHVSEEFSG AQVAFVSSAD AIEAVKSLEK
760 770 780 790 800
ANPFGETLVN FRLQQKLITV QRNIAPRMPV ISHVSPVPKP NNIPTSMDAM
810 820 830 840 850
RQNLLMMTAM LEKSGDSLSR ETKAKLKSEI TGLLEKDGVK LLNTWLEGER
860 870 880 890 900
SITFCRFLSQ NTAKLKLDEI PNAETWPFLV KLLLQCVSME VSGSKRRMPK
910 920 930 940 950
PTFAKTLRVV VQRTEETKFP GVQFPLLSMA KTLFTHVHDI LSNTPSFQSE
960 970 980 990 1000
YGTILRHLLE IKEYRFQMRK RTYSSLVLLY MERAETGFCE KNSGQHSQKE
1010 1020 1030 1040 1050
EAFRYILTLQ SLLENSPGDF PDDLREEIVN GLIHIFSSVR DEGKLSRKLI
1060 1070 1080 1090 1100
ECVNTFLLKD GPNLGSLSLE IHNAVEQFVF RCWLTTHDKN LKEILVSYGR
1110 1120 1130 1140 1150
LQLNLTRDSS ESSSLVEQLL DVVTRELDLG SSSSSASWGD TTKDEKLGAL
1160 1170 1180 1190 1200
SSYQNSLVEL AAHVFYRACV NTSRPSLSEK RARRQHIAMR MVDALTEGKW
1210 1220 1230 1240 1250
LWCAAFGCLV RNYCARINMD LLIYWFEAIC TNFQRLLEDA SMRRSYDGLL
1260 1270 1280 1290 1300
WTLRSLQGLS SGLSLPDITM DISKSSASSS ELDRGWQSIW SSLIHGLATF
1310 1320 1330 1340 1350
SSMSVIVDAV LVLLGSIISS NHITVKILPQ EVWDHQLFRH IPSEPALYFI
1360 1370 1380 1390 1400
ACYFSRMGCQ GNLQDDLHLR RNLLRAVCAP LSWKVRLTLD ERMVQLLPAA
1410 1420 1430 1440 1450
AFSLCAGFKV SLPLPKEHLP TPSQWDVCEQ IDDVDRERNF GLFECSVEAL
1460 1470 1480 1490 1500
TRICSNSSKI SGCQVPDVVQ LPLVLRDPLL HDMDIYFLSI IPEVKEKGPL
1510 1520 1530 1540 1550
SDIFMGCALL CHFMHGSYIT RKGKGSSSFF LKACQYLLEG LDHAVESVSK
1560 1570 1580 1590 1600
SLNDLQRRGS LGFGSDFNEK GSIIVSLRSF TQSPVFSNRR DQNLLGASYD
1610 1620 1630 1640 1650
FVIHSLENLL RSFAKVYEEY TEHAWNTHSD TVPSKSLAPD SPEVGRIVDM
1660 1670 1680 1690 1700
DLDLAEDTKE RDIIAAGGKA VPGLPVSMGN WKLGMVSLIS CFSPVLQFPT
1710 1720 1730 1740 1750
WDVLYNLLEK ESDPKVLENI LYHLCKLSCL TSIPKVDDLV IFLDGMLSTQ
1760 1770 1780 1790 1800
VKMKRNCLNI VTALHVLLHT LSSSRRDSSG VEKNCGLSLK EAESFQVFVQ
1810 1820 1830 1840 1850
LGAMVNKVSE FGLLGWFGRV KLINCICDLV LLNPQTGQTM IERLLLMLSD
1860 1870 1880 1890 1900
SDYRVRFVLA RQIGILFQTW DGHEALFQDI CSSFGIKLVT SSKEKLVTAK
1910 1920 1930 1940 1950
DVLAVGPQPR QKMETVIITL MHLAYHSENI ELQAVFMMCA VSAKDPCQRE
1960 1970 1980 1990 2000
LIIAALDNLS AQLHYPSRFK YLEELLGPIL FHWIASGVSL AGLIETSQLF
2010 2020 2030 2040 2050
IPNAEPKYFI HFCSHWLLPA LLLHEDHTNL DWVAKMAGQP VVVLVKENFV
2060 2070 2080 2090 2100
PIFSICMGLH CSKTSECDKG AMVLQNSILY VGETSENERD KLIKQNMVSI
2110 2120 2130 2140 2150
VSFILSCASS SPEPPVPTFS RDTISLAVQT VVDGFLENTD YPKNAAITDR
2160 2170 2180 2190 2200
INIFRPDRVF MFITEMHYRM SAACHHRHTR HHLAALEELT ILLGHRALVP
2210 2220 2230 2240 2250
SSLNYIFNLV GQFIGYPSLQ DQCCSIASCL LDLFKSNPAK EIVSVLGDQL
2260 2270 2280 2290 2300
QFLVSKLVTC CIDAEADTKI SGAKSSQLVN LLHKLVVSSD SSLNEDIRDL
2310 2320 2330 2340 2350
EPLPDLKYFQ VIRESHIRIC EAYSPRNHLL KVEHSTFLIY IFLEILSLSN
2360 2370 2380 2390 2400
FLFLSCSTIQ QCSRRSNYLP PRFLSRSLQA LHNKLIASEV SQEDTNGETA
2410 2420 2430 2440 2450
ETFWQSDDEI VNAVWTLVRV SASDEADSMR LLVSDFLSRI GIRDPHTVVF
2460 2470 2480 2490 2500
HLPGNLVSMH GLQGFGHNTG SKVRSLTENG ISDETLITLL NFLKKYLLDD
2510 2520 2530 2540 2550
SVKIIDVTSQ TLRGILSTER GQQALSSFDS CERALIEVHG RGVNLDIVEK
2560 2570 2580 2590 2600
ILLDSQKQFK AEKFSLETPE VWSTDNKNFD RWICQLVYCM IALCEDVPIR
2610 2620 2630 2640 2650
LCQNIALLKA EISELLFPSV VVSLAGRIGM DINLHDLITS QVKEHIFTDS
2660 2670 2680 2690 2700
NKLTKSKQVM LNTLNELRMC YVLERSIFSG QTKREKNSRS CSTAAKIRDV
2710 2720 2730 2740 2750
ESGSNGMAAS ITTNWEKVYW LSIDYLVVAG SAVVCGAYLT ASMYVEYWCE
2760 2770 2780 2790 2800
EKFGNLSLGD PDFSYHDKLP DHVEILVSAI TRINEPDSLY GVIHSNKLSA
2810 2820 2830 2840 2850
QIITFEHEGN WTRALEYYDL QARSQKMVVP SSLSENLEVE QFQPTTSARH
2860 2870 2880 2890 2900
SVFGEGEVQR QPFKGLIRSL QQTGCMHVLD LYCRGLTSRE GCFQYDPEFI
2910 2920 2930 2940 2950
ELQYEAAWRA GKWDFSLLYP QTHCQPLQHA KNNNYHESLH CCLRALQEGD
2960 2970 2980 2990 3000
YDGFYGKLKD TKKELVLSIS RASEESTEFI YSTVVKLQIL HHLGLVWDLR
3010 3020 3030 3040 3050
WTTSSHQSVH GYLVKQMACV DPVIPTMDQL SWLNKDWNSI ITQTQLHMTL
3060 3070 3080 3090 3100
LEPFIAFRRV LLQILGCEKC TMQHLLQSAS LLRKGTRFSH AAASLHEFKF
3110 3120 3130 3140 3150
LCARSNGQQP VPDWLGKLEE AKLLHAQGRH EVSISLANYI LHNYQLKEEA
3160 3170 3180 3190 3200
SDIYRVIGKW LAETRSSNSR TILEKYLRPA VSLAEEQSSK ICKRLVDRQS
3210 3220 3230 3240 3250
QTWFHLAHYA DALFKSYEER LSSSEWQAAL RLRKHKTKEL EVFIKRFKSS
3260 3270 3280 3290 3300
KKAEQSDYSL KIQDLQKQLT MDKEEAEKLQ VDRDNFLKLA LEGYKRCLEI
3310 3320 3330 3340 3350
GDKYDVRVVF RQVSMWFSLA SQKNVIDNML STIKEVQSYK FIPLVYQIAS
3360 3370 3380 3390 3400
RLGSSKDESG SNSFQSALVS LIRKMAIDHP YHTILQLLAL ANGDRIKDNQ
3410 3420 3430 3440 3450
RSRNSFVVDM DKKLAAEHLL QDVSHYHGPM IRQMKQLVDI YIKLAELETR
3460 3470 3480 3490 3500
REDTNRKVAL PREIRSVKQL ELVPVVTATI PVDRSCQYNE GSFPFFRGLS
3510 3520 3530 3540 3550
DSVTVMNGIN APKVVECFGS DGQKYKQLAK SGNDDLRQDA VMEQFFGLVN
3560 3570 3580 3590 3600
TFLHNNRDTW KRRLAVRTYK VIPFTPSAGV LEWVDGTIPL GDYLIGSSRS
3610 3620 3630 3640 3650
EGAHGRYGIG NWKYPKCREH MSSAKDKRKA FVDVCTNFRP VMHYFFLEKF
3660 3670 3680 3690 3700
LQPADWFVKR LAYTRSVAAS SMVGYIVGLG DRHAMNILID QATAEVVHID
3710 3720 3730 3740 3750
LGVAFEQGLM LKTPERVPFR LTRDIIDGMG ITGVEGVFRR CCEETLSVMR
3760 3770 3780 3790 3800
TNKEALLTIV EVFIHDPLYK WALSPLKALQ RQKETEDYDG MNLEGLQEEF
3810 3820 3830 3840 3850
EGNKDATRAL MRVKQKLDGY EGGEMRSIHG QAQQLIQDAI DTDRLSHMFP

GWGAWM
Length:3,856
Mass (Da):435,114
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i934D08DC3C67A180
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I9LQ78A0A1I9LQ78_ARATH
Serine/Threonine-kinase ATM-like pr...
ATM ATATM, ataxia-telangiectasia mutated, pcd in male gametogenesis 1, PIG1, At3g48190
2,989Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1I9LQ79A0A1I9LQ79_ARATH
Serine/Threonine-kinase ATM-like pr...
ATM ATATM, ataxia-telangiectasia mutated, pcd in male gametogenesis 1, PIG1, At3g48190
3,013Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3640P → S in CAB86487 (PubMed:10734187).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ250248 mRNA Translation: CAB86487.1
AL096856 Genomic DNA Translation: CAB92122.1
CP002686 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
T51174

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250248 mRNA Translation: CAB86487.1
AL096856 Genomic DNA Translation: CAB92122.1
CP002686 Genomic DNA No translation available.
PIRiT51174

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi9294, 2 interactors
STRINGi3702.AT3G48190.1

Proteomic databases

PaxDbiQ9M3G7
PRIDEiQ9M3G7

Organism-specific databases

AraportiAT3G48190

Phylogenomic databases

eggNOGiKOG0892 Eukaryota
ENOG410XNPY LUCA
InParanoidiQ9M3G7
OrthoDBi80538at2759
PhylomeDBiQ9M3G7

Enzyme and pathway databases

BioCyciARA:AT3G48190-MONOMER

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9M3G7

Gene expression databases

ExpressionAtlasiQ9M3G7 baseline and differential
GenevisibleiQ9M3G7 AT

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038980 ATM_plant
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR000313 PWWP_dom
PANTHERiPTHR37079 PTHR37079, 1 hit
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS50812 PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATM_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M3G7
Secondary accession number(s): F4JDV3, Q9M4D7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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