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Protein

Beclin-1-like protein

Gene

ATG6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal plant development (PubMed:17339883, PubMed:17932459, PubMed:18227644). Required for pollen germination (PubMed:17339883, PubMed:17259285, PubMed:18227644). Required for autophagic activity. Required to limit the pathogen-associated cell death response (PubMed:17932459). May be involved in vacuolar protein sorting (PubMed:17259285). Binds to microtubules. May facilitate efficient recruitment of other ATG proteins to assemble scaffolds for autophagosome biogenesis (PubMed:26566764).5 Publications

Miscellaneous

Plants silencing ATG6 exhibit impaired autophagic activity and accelerated senescence.1 Publication

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • autophagy of nucleus Source: GO_Central
  • cellular response to nitrogen starvation Source: GO_Central
  • defense response to fungus Source: TAIR
  • late endosome to vacuole transport Source: GO_Central
  • pollen germination Source: TAIR
  • protein targeting to vacuole Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-ATH-1632852 Macroautophagy
R-ATH-5689880 Ub-specific processing proteases

Protein family/group databases

TCDBi9.A.15.3.1 the autophagy-related phagophore-formation transporter (apt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Beclin-1-like proteinCurated
Short name:
AtBECLIN 11 Publication
Alternative name(s):
Autophagy protein 61 Publication
Short name:
AtATG61 Publication
Protein VPS30 homolog1 Publication
Short name:
AtVPS301 Publication
Gene namesi
Name:ATG61 Publication
Synonyms:VPS301 Publication
Ordered Locus Names:At3g61710Imported
ORF Names:F15G16.100Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G61710
TAIRilocus:2076715 AT3G61710

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Biotechnological usei

Can be used to induced male sterility when expressed in anther tapetum. Development of male sterile lines is important for commercial hybrid seed production.1 Publication

Disruption phenotypei

Male sterility due to pollen germination defect.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185581 – 517Beclin-1-like proteinAdd BLAST517

Post-translational modificationi

Ubiquitinated (PubMed:28351989). The interaction with SINAT1 or SINAT2, and the presence of TRAF1A/MUSE14 and TRAF1B/MUSE13, mediates its proteasome-dependent degradation (PubMed:28351989).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9M367

Expressioni

Tissue specificityi

Highly expressed in mature pollen grains (PubMed:17339883). Expressed in roots, leaves, stems, flowers and siliques (PubMed:17259285, PubMed:18227644).3 Publications

Inductioni

Induced by infection with the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000 (PubMed:17932459). Induced by infection with the fungal necrotrophic pathogen Botrytis cinerea (PubMed:21395886).2 Publications

Gene expression databases

ExpressionAtlasiQ9M367 baseline and differential
GenevisibleiQ9M367 AT

Interactioni

Subunit structurei

Component of a phosphatidylinositol 3-kinase (PI3K) complex composed of ATG6, SH3P2 and FREE1 (PubMed:25624505). Interacts with SINAT1, SINAT2, SINAT5, SINAT6, TRAF1A and TRAF1B (PubMed:28351989). Interacts with TUBB8/TUB8 (PubMed:26566764).3 Publications

Protein-protein interaction databases

BioGridi10658, 4 interactors
STRINGi3702.AT3G61710.1

Structurei

3D structure databases

ProteinModelPortaliQ9M367
SMRiQ9M367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili172 – 266Sequence analysisAdd BLAST95

Sequence similaritiesi

Belongs to the beclin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2751 Eukaryota
ENOG410XQ85 LUCA
HOGENOMiHOG000240270
InParanoidiQ9M367
KOiK08334
OMAiMRYAQMQ
OrthoDBiEOG093607NO
PhylomeDBiQ9M367

Family and domain databases

Gene3Di1.10.418.40, 1 hit
InterProiView protein in InterPro
IPR007243 Atg6/Beclin
IPR038274 Atg6/Beclin_C_sf
PANTHERiPTHR12768 PTHR12768, 1 hit
PfamiView protein in Pfam
PF04111 APG6, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9M367-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKEEIPDKS RTIPIDPNLP KWVCQNCHHS LTIVGVDSYA GKFFNDPPPS
60 70 80 90 100
ATQGSSIHGA NSVLGSTRMD NSFVVLPRHK PPQSQGIPPR PRGASSPQPD
110 120 130 140 150
ATQSGKAMEE SFVVVYKSEP VSDSGGSHNL SLEVGQNGPL HSNTSGFNAT
160 170 180 190 200
INVLTRAFDI ARTQTQVEQP LCLECMRVLS DKLEKEVEDV TRDVEAYEAC
210 220 230 240 250
VQRLEGETQD VLSEADFLKE KKKIEEEERK LVAAIEETEK QNAEVNHQLK
260 270 280 290 300
ELEFKGNRFN ELEDRYWQEF NNFQFQLIAH QEERDAILAK IEVSQAHLEL
310 320 330 340 350
LNKTNVLIDA FPIRNDGEFG TINNFRLGRL PAIKVEWDEI NAAWGQACLL
360 370 380 390 400
LHTMCNYFRP KFQCQVKIQP MGSYPRIVDS NNETYELFGP VNLFWSTRYD
410 420 430 440 450
KAMTLYLMCL KDFADFANSK DQENNIPPDN CLNLPYKIEK DKVLGYSITQ
460 470 480 490 500
SFNKQESWTK ALKYTLCNLK WALYWFVGNT NFQPLSATVS LPSNISAAGS
510
LYAKRGPDSS KPSCKKT
Length:517
Mass (Da):58,504
Last modified:May 29, 2007 - v2
Checksum:i15E3D9A40A5C15BE
GO
Isoform 2 (identifier: Q9M367-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-386: CQVKIQPMGSYPRIVDSNNETYE → YPYNYLTVLFLILPFLFDSVDCI
     387-517: Missing.

Show »
Length:386
Mass (Da):43,752
Checksum:i5EC5A97D2E1DDA02
GO
Isoform 3 (identifier: Q9M367-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     364-386: CQVKIQPMGSYPRIVDSNNETYE → YPYNYLTVLFLILPFLFDSVDCI
     387-517: Missing.

Show »
Length:318
Mass (Da):36,366
Checksum:i0B7C7B90A318A46E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I9LT68A0A1I9LT68_ARATH
AUTOPHAGY 6
ATG6 ATATG6, AtBECLIN1, AUTOPHAGY 6, BECLIN1, At3g61710 ATG6 ATATG6, AtBECLIN1, AUTOPHAGY 6, BECLIN1, At3g61710, F21F14.6
467Annotation score:

Sequence cautioni

The sequence CAB71101 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0579131 – 68Missing in isoform 3. Add BLAST68
Alternative sequenceiVSP_057914364 – 386CQVKI…NETYE → YPYNYLTVLFLILPFLFDSV DCI in isoform 2 and isoform 3. Add BLAST23
Alternative sequenceiVSP_057915387 – 517Missing in isoform 2 and isoform 3. Add BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132959 Genomic DNA Translation: CAB71101.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE80244.1
CP002686 Genomic DNA Translation: AEE80245.1
CP002686 Genomic DNA Translation: AEE80246.1
AY039613 mRNA Translation: AAK62668.1
BT000508 mRNA Translation: AAN18077.1
PIRiT47963
RefSeqiNP_001030914.1, NM_001035837.1 [Q9M367-3]
NP_567116.1, NM_116036.4 [Q9M367-1]
NP_974475.1, NM_202746.2 [Q9M367-2]
UniGeneiAt.958

Genome annotation databases

EnsemblPlantsiAT3G61710.1; AT3G61710.1; AT3G61710 [Q9M367-1]
AT3G61710.2; AT3G61710.2; AT3G61710 [Q9M367-2]
AT3G61710.3; AT3G61710.3; AT3G61710 [Q9M367-3]
GeneIDi825344
GrameneiAT3G61710.1; AT3G61710.1; AT3G61710 [Q9M367-1]
AT3G61710.2; AT3G61710.2; AT3G61710 [Q9M367-2]
AT3G61710.3; AT3G61710.3; AT3G61710 [Q9M367-3]
KEGGiath:AT3G61710

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132959 Genomic DNA Translation: CAB71101.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE80244.1
CP002686 Genomic DNA Translation: AEE80245.1
CP002686 Genomic DNA Translation: AEE80246.1
AY039613 mRNA Translation: AAK62668.1
BT000508 mRNA Translation: AAN18077.1
PIRiT47963
RefSeqiNP_001030914.1, NM_001035837.1 [Q9M367-3]
NP_567116.1, NM_116036.4 [Q9M367-1]
NP_974475.1, NM_202746.2 [Q9M367-2]
UniGeneiAt.958

3D structure databases

ProteinModelPortaliQ9M367
SMRiQ9M367
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10658, 4 interactors
STRINGi3702.AT3G61710.1

Protein family/group databases

TCDBi9.A.15.3.1 the autophagy-related phagophore-formation transporter (apt) family

Proteomic databases

PaxDbiQ9M367

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G61710.1; AT3G61710.1; AT3G61710 [Q9M367-1]
AT3G61710.2; AT3G61710.2; AT3G61710 [Q9M367-2]
AT3G61710.3; AT3G61710.3; AT3G61710 [Q9M367-3]
GeneIDi825344
GrameneiAT3G61710.1; AT3G61710.1; AT3G61710 [Q9M367-1]
AT3G61710.2; AT3G61710.2; AT3G61710 [Q9M367-2]
AT3G61710.3; AT3G61710.3; AT3G61710 [Q9M367-3]
KEGGiath:AT3G61710

Organism-specific databases

AraportiAT3G61710
TAIRilocus:2076715 AT3G61710

Phylogenomic databases

eggNOGiKOG2751 Eukaryota
ENOG410XQ85 LUCA
HOGENOMiHOG000240270
InParanoidiQ9M367
KOiK08334
OMAiMRYAQMQ
OrthoDBiEOG093607NO
PhylomeDBiQ9M367

Enzyme and pathway databases

ReactomeiR-ATH-1632852 Macroautophagy
R-ATH-5689880 Ub-specific processing proteases

Miscellaneous databases

PROiPR:Q9M367

Gene expression databases

ExpressionAtlasiQ9M367 baseline and differential
GenevisibleiQ9M367 AT

Family and domain databases

Gene3Di1.10.418.40, 1 hit
InterProiView protein in InterPro
IPR007243 Atg6/Beclin
IPR038274 Atg6/Beclin_C_sf
PANTHERiPTHR12768 PTHR12768, 1 hit
PfamiView protein in Pfam
PF04111 APG6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBECN1_ARATH
AccessioniPrimary (citable) accession number: Q9M367
Secondary accession number(s): A8MRV3, F4JFF7, Q94BW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 29, 2007
Last modified: October 10, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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