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Entry version 110 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Cation/H(+) antiporter 20

Gene

CHX20

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Operates as a K+/H+ antiporter that maintains K+ homeostasis in guard cells and could regulate pH. Plays a critical role in osmoregulation through the control of stomates opening.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Potassium transport, Transport
LigandPotassium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.37.4.8, the monovalent cation:proton antiporter-2 (cpa2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation/H(+) antiporter 20
Alternative name(s):
Protein CATION/H+ EXCHANGER 20
Short name:
AtCHX20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHX20
Ordered Locus Names:At3g53720
ORF Names:F5K20_20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G53720

The Arabidopsis Information Resource

More...
TAIRi
locus:2084370, AT3G53720

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impaired light-induced stomatal opening.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003949901 – 842Cation/H(+) antiporter 20Add BLAST842

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9M353

PRoteomics IDEntifications database

More...
PRIDEi
Q9M353

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
246919

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9M353

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in leaves and stems. Preferentially expressed in guards cells.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M353, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M353, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
9856, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9M353, 6 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G53720.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni585 – 605DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1650, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005126_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9M353

Database of Orthologous Groups

More...
OrthoDBi
336706at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M353

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153, Cation/H_exchanger
IPR038770, Na+/solute_symporter_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9M353-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFNITSVKT SSNGVWQGDN PLNFAFPLLI VQTALIIAVS RFLAVLFKPL
60 70 80 90 100
RQPKVIAEIV GGILLGPSAL GRNMAYMDRI FPKWSMPILE SVASIGLLFF
110 120 130 140 150
LFLVGLELDL SSIRRSGKRA FGIAVAGITL PFIAGVGVAF VIRNTLYTAA
160 170 180 190 200
DKPGYAEFLV FMGVALSITA FPVLARILAE LKLLTTQIGE TAMAAAAFND
210 220 230 240 250
VAAWILLALA VALAGNGGEG GGEKKSPLVS LWVLLSGAGF VVFMLVVIRP
260 270 280 290 300
GMKWVAKRGS PENDVVRESY VCLTLAGVMV SGFATDLIGI HSIFGAFVFG
310 320 330 340 350
LTIPKDGEFG QRLIERIEDF VSGLLLPLYF ATSGLKTDVA KIRGAESWGM
360 370 380 390 400
LGLVVVTACA GKIVGTFVVA VMVKVPAREA LTLGFLMNTK GLVELIVLNI
410 420 430 440 450
GKEKKVLNDE TFAILVLMAL FTTFITTPTV MAIYKPARGT HRKLKDLSAS
460 470 480 490 500
QDSTKEELRI LACLHGPANV SSLISLVESI RTTKILRLKL FVMHLMELTE
510 520 530 540 550
RSSSIIMVQR ARKNGLPFVH RYRHGERHSN VIGGFEAYRQ LGRVAVRPIT
560 570 580 590 600
AVSPLPTMHE DICHMADTKR VTMIILPFHK RWNADHGHSH HHQDGGGDGN
610 620 630 640 650
VPENVGHGWR LVNQRVLKNA PCSVAVLVDR GLGSIEAQTL SLDGSNVVER
660 670 680 690 700
VCVIFFGGPD DRESIELGGR MAEHPAVKVT VIRFLVRETL RSTAVTLRPA
710 720 730 740 750
PSKGKEKNYA FLTTNVDPEK EKELDEGALE DFKSKWKEMV EYKEKEPNNI
760 770 780 790 800
IEEILSIGQS KDFDLIVVGR GRIPSAEVAA LAERQAEHPE LGPIGDVLAS
810 820 830 840
SINHIIPSIL VVQQHNKAHV EDITVSKIVS ESSLSINGDT NV
Length:842
Mass (Da):91,553
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD69A1295C5491A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I9LL89A0A1I9LL89_ARATH
Cation/H+ exchanger 20
CHX20 ATCHX20, cation, H+ exchanger 20, At3g53720
769Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL132960 Genomic DNA Translation: CAB88334.1
CP002686 Genomic DNA Translation: AEE79132.1
BT002529 mRNA Translation: AAO00889.1
BT010870 mRNA Translation: AAR24648.1
AK227229 mRNA Translation: BAE99266.1
AY926476 mRNA Translation: AAX49548.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T45912

NCBI Reference Sequences

More...
RefSeqi
NP_190940.1, NM_115232.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G53720.1; AT3G53720.1; AT3G53720

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
824539

Gramene; a comparative resource for plants

More...
Gramenei
AT3G53720.1; AT3G53720.1; AT3G53720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G53720

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132960 Genomic DNA Translation: CAB88334.1
CP002686 Genomic DNA Translation: AEE79132.1
BT002529 mRNA Translation: AAO00889.1
BT010870 mRNA Translation: AAR24648.1
AK227229 mRNA Translation: BAE99266.1
AY926476 mRNA Translation: AAX49548.1
PIRiT45912
RefSeqiNP_190940.1, NM_115232.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi9856, 7 interactors
IntActiQ9M353, 6 interactors
STRINGi3702.AT3G53720.1

Protein family/group databases

TCDBi2.A.37.4.8, the monovalent cation:proton antiporter-2 (cpa2) family

PTM databases

iPTMnetiQ9M353

Proteomic databases

PaxDbiQ9M353
PRIDEiQ9M353
ProteomicsDBi246919

Genome annotation databases

EnsemblPlantsiAT3G53720.1; AT3G53720.1; AT3G53720
GeneIDi824539
GrameneiAT3G53720.1; AT3G53720.1; AT3G53720
KEGGiath:AT3G53720

Organism-specific databases

AraportiAT3G53720
TAIRilocus:2084370, AT3G53720

Phylogenomic databases

eggNOGiKOG1650, Eukaryota
HOGENOMiCLU_005126_6_2_1
InParanoidiQ9M353
OrthoDBi336706at2759
PhylomeDBiQ9M353

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9M353

Gene expression databases

ExpressionAtlasiQ9M353, baseline and differential
GenevisibleiQ9M353, AT

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR038770, Na+/solute_symporter_sf
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHX20_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M353
Secondary accession number(s): Q58P63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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