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Entry version 136 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Proline--tRNA ligase, cytoplasmic

Gene

At3g62120

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline--tRNA ligase, cytoplasmicCurated (EC:6.1.1.15Curated)
Alternative name(s):
Prolyl-tRNA synthetaseCurated
Short name:
ProRSCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At3g62120Imported
ORF Names:T17J13.80Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G62120

The Arabidopsis Information Resource

More...
TAIRi
locus:2098053 AT3G62120

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004335411 – 530Proline--tRNA ligase, cytoplasmicAdd BLAST530

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9M1R2

PRoteomics IDEntifications database

More...
PRIDEi
Q9M1R2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9M1R2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M1R2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M1R2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9M1R2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G62120.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9M1R2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 54Lys-richPROSITE-ProRule annotationAdd BLAST47

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4163 Eukaryota
COG0442 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000167538

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9M1R2

KEGG Orthology (KO)

More...
KOi
K01881

Database of Orthologous Groups

More...
OrthoDBi
509367at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M1R2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00778 ProRS_core_arch_euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.110.30, 1 hit
3.40.50.800, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01571 Pro_tRNA_synth_type3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
IPR033721 ProRS_core_arch_euk

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09180 ProRS-C_1, 1 hit
PF00587 tRNA-synt_2b, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01046 TRNASYNTHPRO

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00946 ProRS-C_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64586 SSF64586, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00408 proS_fam_I, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9M1R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPSEQKEK VVKEKKEKVK KEKVVKEKVA KASSSGQKKK DVKKETGLGL
60 70 80 90 100
SVKKDENFGE WYSEVCKQDM IEYYDISGCY ILRPWSMAIW EIMQIFFDAE
110 120 130 140 150
IKKMKVKNCY FPLFVSPGVL EKEKDHIEGF APEVAWVTKS GKSDLEVPIA
160 170 180 190 200
IRPTSETVMY PYYSKWIRGH RDLPLKLNQW CNVVRWEFSN PTPFIRSREF
210 220 230 240 250
LWQEGHTAFA TKAEADEEVL QILELYRRIY EEYLAVPVVK GMKSENEKFA
260 270 280 290 300
GGLYTTSVEA FIPNTGRGVQ GATSHCLGQN FAKMFEINFE NEKAETEMVW
310 320 330 340 350
QNSWAYSTRT IGVMIMTHGD DKGLVLPPKV ASVQVVVIPV PYKDANTQGI
360 370 380 390 400
YDACTATASA LCEAGIRAEE DLRDNYSPGW KYSDWEMKGV PLRIEIGPRD
410 420 430 440 450
LENDQVRTVR RDNGVKEDIP RGSLVEHVKE LLEKIQQNMY EVAKQKREAC
460 470 480 490 500
VQEVKTWDEF IKALNEKKLI LAPWCDEEEV ERDVKARTKG ETGAAKTLCS
510 520 530
PFDQPELPEG TLCFASGKPA KKWTYWGRSY
Length:530
Mass (Da):60,756
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF170683CFE5E8DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I9LNS4A0A1I9LNS4_ARATH
Class II aaRS and biotin synthetase...
At3g62120
517Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL138651 Genomic DNA Translation: CAB71872.1
CP002686 Genomic DNA Translation: AEE80312.1
CP002686 Genomic DNA Translation: AEE80313.1
AY059812 mRNA Translation: AAL24294.1
AY128720 mRNA Translation: AAM91120.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T48004

NCBI Reference Sequences

More...
RefSeqi
NP_191771.1, NM_116077.3
NP_850736.1, NM_180405.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G62120.1; AT3G62120.1; AT3G62120
AT3G62120.2; AT3G62120.2; AT3G62120

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
825385

Gramene; a comparative resource for plants

More...
Gramenei
AT3G62120.1; AT3G62120.1; AT3G62120
AT3G62120.2; AT3G62120.2; AT3G62120

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G62120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138651 Genomic DNA Translation: CAB71872.1
CP002686 Genomic DNA Translation: AEE80312.1
CP002686 Genomic DNA Translation: AEE80313.1
AY059812 mRNA Translation: AAL24294.1
AY128720 mRNA Translation: AAM91120.1
PIRiT48004
RefSeqiNP_191771.1, NM_116077.3
NP_850736.1, NM_180405.1

3D structure databases

SMRiQ9M1R2
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9M1R2, 3 interactors
STRINGi3702.AT3G62120.1

PTM databases

iPTMnetiQ9M1R2

Proteomic databases

PaxDbiQ9M1R2
PRIDEiQ9M1R2

Genome annotation databases

EnsemblPlantsiAT3G62120.1; AT3G62120.1; AT3G62120
AT3G62120.2; AT3G62120.2; AT3G62120
GeneIDi825385
GrameneiAT3G62120.1; AT3G62120.1; AT3G62120
AT3G62120.2; AT3G62120.2; AT3G62120
KEGGiath:AT3G62120

Organism-specific databases

AraportiAT3G62120
TAIRilocus:2098053 AT3G62120

Phylogenomic databases

eggNOGiKOG4163 Eukaryota
COG0442 LUCA
HOGENOMiHOG000167538
InParanoidiQ9M1R2
KOiK01881
OrthoDBi509367at2759
PhylomeDBiQ9M1R2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9M1R2

Gene expression databases

ExpressionAtlasiQ9M1R2 baseline and differential
GenevisibleiQ9M1R2 AT

Family and domain databases

CDDicd00778 ProRS_core_arch_euk, 1 hit
Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
IPR033721 ProRS_core_arch_euk
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09180 ProRS-C_1, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SMARTiView protein in SMART
SM00946 ProRS-C_1, 1 hit
SUPFAMiSSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYPC_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M1R2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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