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Entry version 140 (07 Apr 2021)
Sequence version 2 (24 May 2004)
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Protein

Dehydration-responsive element-binding protein 1A

Gene

DREB1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi50 – 107AP2/ERFPROSITE-ProRule annotationAdd BLAST58

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dehydration-responsive element-binding protein 1A1 Publication
Short name:
Protein DREB1A1 Publication
Alternative name(s):
C-repeat/dehydration-responsive element-binding factor 31 Publication
Short name:
C-repeat-binding factor 31 Publication
Short name:
CRT/DRE-binding factor 31 Publication
Cold resistance-related AP2 transcription factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DREB1A1 Publication
Synonyms:CBF31 Publication, CRAP2, ERF0721 Publication
Ordered Locus Names:At4g25480Imported
ORF Names:M7J2.150Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G25480

The Arabidopsis Information Resource

More...
TAIRi
locus:2131849, AT4G25480

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63V → A: Affects the binding to the CRT/DRE cis-element. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001125281 – 216Dehydration-responsive element-binding protein 1AAdd BLAST216

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9M0L0

PRoteomics IDEntifications database

More...
PRIDEi
Q9M0L0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
220546

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By cold stress. Positively regulated by the transcription factor ICE1. Subject to degradation by the 26S proteasome pathway in freezing conditions (PubMed:28344081).4 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M0L0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M0L0, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with 14-3-3 proteins GRF1, GRF3, GRF5, GRF6, GRF7, GRF9 and GRF10 in the nucleus upon freezing.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
13939, 6 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G25480.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9M0L0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi35 – 47Nuclear localization signalSequence analysisAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi205 – 210Poly-Asp6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ5M, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_063331_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9M0L0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MNMEEAT

Database of Orthologous Groups

More...
OrthoDBi
1352198at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M0L0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00018, AP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001471, AP2/ERF_dom
IPR036955, AP2/ERF_dom_sf
IPR016177, DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00847, AP2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00367, ETHRSPELEMNT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00380, AP2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54171, SSF54171, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51032, AP2_ERF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9M0L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSFSAFSEM FGSDYESSVS SGGDYIPTLA SSCPKKPAGR KKFRETRHPI
60 70 80 90 100
YRGVRRRNSG KWVCEVREPN KKTRIWLGTF QTAEMAARAH DVAALALRGR
110 120 130 140 150
SACLNFADSA WRLRIPESTC AKDIQKAAAE AALAFQDEMC DATTDHGFDM
160 170 180 190 200
EETLVEAIYT AEQSENAFYM HDEAMFEMPS LLANMAEGML LPLPSVQWNH
210
NHEVDGDDDD VSLWSY
Length:216
Mass (Da):24,236
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC625E2D0FAE0FFFB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABD72616 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence CAA18178 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB81358 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti146H → Y in BAA33434 (PubMed:9735350).Curated1
Sequence conflicti146H → Y in AAU93686 (Ref. 6) Curated1
Sequence conflicti146H → Y in ABD14412 (Ref. 7) Curated1
Sequence conflicti193L → P in ABD72616 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2N → S in strain: cv. Cvi-1. 1 Publication1
Natural varianti19V → I in strain: cv. Cvi-1. 1 Publication1
Natural varianti142A → V in strain: cv. Cvi-1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007787 mRNA Translation: BAA33791.1
AB013815 Genomic DNA Translation: BAA33434.1
AF074602 mRNA Translation: AAD15977.1
AF076155 Genomic DNA Translation: AAC99370.1
AF062924 Genomic DNA Translation: AAC78646.1
AY667247 Genomic DNA Translation: AAV80414.1
AY691904 Genomic DNA Translation: AAU93686.1
DQ372533 Genomic DNA Translation: ABD14412.1
DQ415923 Genomic DNA Translation: ABD72616.1 Sequence problems.
AL022197 Genomic DNA Translation: CAA18178.1 Sequence problems.
AL161563 Genomic DNA Translation: CAB81358.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85065.1
BT024594 mRNA Translation: ABD42992.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D85294
JE0297
T05799
T51830

NCBI Reference Sequences

More...
RefSeqi
NP_567720.1, NM_118680.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G25480.1; AT4G25480.1; AT4G25480

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
828652

Gramene; a comparative resource for plants

More...
Gramenei
AT4G25480.1; AT4G25480.1; AT4G25480

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G25480

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007787 mRNA Translation: BAA33791.1
AB013815 Genomic DNA Translation: BAA33434.1
AF074602 mRNA Translation: AAD15977.1
AF076155 Genomic DNA Translation: AAC99370.1
AF062924 Genomic DNA Translation: AAC78646.1
AY667247 Genomic DNA Translation: AAV80414.1
AY691904 Genomic DNA Translation: AAU93686.1
DQ372533 Genomic DNA Translation: ABD14412.1
DQ415923 Genomic DNA Translation: ABD72616.1 Sequence problems.
AL022197 Genomic DNA Translation: CAA18178.1 Sequence problems.
AL161563 Genomic DNA Translation: CAB81358.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85065.1
BT024594 mRNA Translation: ABD42992.1
PIRiD85294
JE0297
T05799
T51830
RefSeqiNP_567720.1, NM_118680.2

3D structure databases

SMRiQ9M0L0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi13939, 6 interactors
STRINGi3702.AT4G25480.1

Proteomic databases

PaxDbiQ9M0L0
PRIDEiQ9M0L0
ProteomicsDBi220546

Genome annotation databases

EnsemblPlantsiAT4G25480.1; AT4G25480.1; AT4G25480
GeneIDi828652
GrameneiAT4G25480.1; AT4G25480.1; AT4G25480
KEGGiath:AT4G25480

Organism-specific databases

AraportiAT4G25480
TAIRilocus:2131849, AT4G25480

Phylogenomic databases

eggNOGiENOG502QQ5M, Eukaryota
HOGENOMiCLU_063331_1_0_1
InParanoidiQ9M0L0
OMAiMNMEEAT
OrthoDBi1352198at2759
PhylomeDBiQ9M0L0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9M0L0

Gene expression databases

ExpressionAtlasiQ9M0L0, baseline and differential
GenevisibleiQ9M0L0, AT

Family and domain databases

CDDicd00018, AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471, AP2/ERF_dom
IPR036955, AP2/ERF_dom_sf
IPR016177, DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847, AP2, 1 hit
PRINTSiPR00367, ETHRSPELEMNT
SMARTiView protein in SMART
SM00380, AP2, 1 hit
SUPFAMiSSF54171, SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032, AP2_ERF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRE1A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M0L0
Secondary accession number(s): O65612
, O82131, Q1ZZS0, Q2HII7, Q5QE70, Q5Y4C4, Q9SAZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 7, 2021
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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