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Entry version 143 (11 Dec 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Transcription factor bHLH140

Gene

BHLH140

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi234 – 241ATPSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri870 – 893C2H2-typeAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA replication, Transcription, Transcription regulation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT5G01310-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor bHLH140
Alternative name(s):
Basic helix-loop-helix protein 140
Short name:
AtbHLH140
Short name:
bHLH 140
Transcription factor EN 122
bHLH transcription factor bHLH140
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BHLH140
Synonyms:EN122
Ordered Locus Names:At5g01310
ORF Names:T10O8.20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G01310

The Arabidopsis Information Resource

More...
TAIRi
locus:2179122 AT5G01310

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003588201 – 912Transcription factor bHLH140Add BLAST912

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9M041

PRoteomics IDEntifications database

More...
PRIDEi
Q9M041

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9M041

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M041 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M041 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Curated

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G01310.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9M041

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 92bHLHPROSITE-ProRule annotationAdd BLAST50
Domaini511 – 690MacroPROSITE-ProRule annotationAdd BLAST180
Domaini720 – 829HITPROSITE-ProRule annotationAdd BLAST110

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri870 – 893C2H2-typeAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0562 Eukaryota
KOG2134 Eukaryota
ENOG41102F4 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000083464

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9M041

Database of Orthologous Groups

More...
OrthoDBi
1467445at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M041

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.428.10, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR019808 Histidine_triad_CS
IPR011146 HIT-like
IPR036265 HIT-like_sf
IPR036638 HLH_DNA-bd_sf
IPR002589 Macro_dom
IPR027417 P-loop_NTPase
IPR032566 Znf-C2HE

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit
PF01661 Macro, 1 hit
PF16278 zf-C2HE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506 A1pp, 1 hit
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit
SSF52540 SSF52540, 1 hit
SSF54197 SSF54197, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS00892 HIT_1, 1 hit
PS51084 HIT_2, 1 hit
PS51154 MACRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9M041-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDFNLRSEN PNSSSTTSSS SSSFHRHKSE TGNTKRSRST STLSTDPQSV
60 70 80 90 100
AARDRRHRIS DRFKILQSMV PGGAKMDTVS MLDEAISYVK FLKAQIWYHQ
110 120 130 140 150
NMLLFINDHE TTSSCTYSPG AGEFGPKLFG YDDDYAPIMD TYSQGVPLTV
160 170 180 190 200
ADSKYTPWFG SVDDEQEHVT YFKYRRATRH ALRGHCNCII GETEEFADQR
210 220 230 240 250
EKMEVQIEES GKNQTSPESI EADKAKQIVV LLIGPPGSGK STFCDTAMRS
260 270 280 290 300
SHRPWSRICQ DIVNNGKAGT KAQCLKMATD SLREGKSVFI DRCNLDREQR
310 320 330 340 350
SEFIKLGGPE FEVHAVVLEL PAQVCISRSV KRTGHEGNLQ GGRAAAVVNK
360 370 380 390 400
MLQSKELPKV NEGFSRIMFC YSDADVDNAV NMYNKLGPMD TLPSGCFGEK
410 420 430 440 450
KLDTKSQPGI MKFFKKVSAL PASSSNEATN TTRKADEMTA NVRVSPVKLG
460 470 480 490 500
SADIVPTLAF PSISTADFQF DLEKASDIIV EKAEEFLSKL GTARLVLVDL
510 520 530 540 550
SRGSKILSLV KAKASQKNID SAKFFTFVGD ITKLRSEGGL HCNVIANATN
560 570 580 590 600
WRLKPGGGGV NAAIFKAAGP DLETATRVRA NTLLPGKAVV VPLPSTCPLH
610 620 630 640 650
NAEGITHVIH VLGPNMNPNR PDNLNNDYTK GCKTLREAYT SLFEGFLSVV
660 670 680 690 700
QDQSKLPKRS SQTAVSDSGE DIKEDSERNK KYKGSQDKAV TNNLESESLE
710 720 730 740 750
DTRGSGKKMS KGWNTWALAL HSIAMHPERH ENVVLEYLDN IVVINDQYPK
760 770 780 790 800
ARKHVLVLAR QESLDGLEDV RKENLQLLQE MHNVGLKWVD RFQNEDASLI
810 820 830 840 850
FRLGYHSVPS MRQLHLHVIS QDFNSDSLKN KKHWNSFTTS FFRDSVDVLE
860 870 880 890 900
EVNSQGKANV ASEDLLKGEL RCNRCRSAHP NIPKLKSHVR SCHSQFPDHL
910
LQNNRLVARA ET
Length:912
Mass (Da):101,388
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2F400ED42A09457
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2H1ZE58A0A2H1ZE58_ARATH
APRATAXIN-like protein
APTX APRATAXIN-like, At5g01310, T10O8.20, T10O8_20
710Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A178UDM7A0A178UDM7_ARATH
Transcription factor bHLH140-like p...
At5g01305
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL161746 Genomic DNA Translation: CAB81914.1
CP002688 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
T48153

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G01305.1; AT5G01305.1; AT5G01305
AT5G01310.1; AT5G01310.1; AT5G01310

Gramene; a comparative resource for plants

More...
Gramenei
AT5G01305.1; AT5G01305.1; AT5G01305
AT5G01310.1; AT5G01310.1; AT5G01310

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161746 Genomic DNA Translation: CAB81914.1
CP002688 Genomic DNA No translation available.
PIRiT48153

3D structure databases

SMRiQ9M041
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G01310.1

PTM databases

iPTMnetiQ9M041

Proteomic databases

PaxDbiQ9M041
PRIDEiQ9M041

Genome annotation databases

EnsemblPlantsiAT5G01305.1; AT5G01305.1; AT5G01305
AT5G01310.1; AT5G01310.1; AT5G01310
GrameneiAT5G01305.1; AT5G01305.1; AT5G01305
AT5G01310.1; AT5G01310.1; AT5G01310

Organism-specific databases

AraportiAT5G01310
TAIRilocus:2179122 AT5G01310

Phylogenomic databases

eggNOGiKOG0562 Eukaryota
KOG2134 Eukaryota
ENOG41102F4 LUCA
HOGENOMiHOG000083464
InParanoidiQ9M041
OrthoDBi1467445at2759
PhylomeDBiQ9M041

Enzyme and pathway databases

BioCyciARA:AT5G01310-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9M041

Gene expression databases

ExpressionAtlasiQ9M041 baseline and differential
GenevisibleiQ9M041 AT

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di3.30.428.10, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR019808 Histidine_triad_CS
IPR011146 HIT-like
IPR036265 HIT-like_sf
IPR036638 HLH_DNA-bd_sf
IPR002589 Macro_dom
IPR027417 P-loop_NTPase
IPR032566 Znf-C2HE
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF01661 Macro, 1 hit
PF16278 zf-C2HE, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF52540 SSF52540, 1 hit
SSF54197 SSF54197, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS00892 HIT_1, 1 hit
PS51084 HIT_2, 1 hit
PS51154 MACRO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBH140_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M041
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 1, 2000
Last modified: December 11, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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