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Protein

Probable glutathione peroxidase 5

Gene

GPX5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46By similarity1

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in seed dormancy Source: TAIR
  • response to oxidative stress Source: InterPro

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processStress response

Enzyme and pathway databases

BioCyciARA:AT3G63080-MONOMER
ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei2475 AtGPx05

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 5 (EC:1.11.1.9)
Gene namesi
Name:GPX5
Ordered Locus Names:At3g63080
ORF Names:T20O10_180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G63080
TAIRilocus:2099252 AT3G63080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000666392 – 173Probable glutathione peroxidase 5Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ9LYB4
PRIDEiQ9LYB4

PTM databases

iPTMnetiQ9LYB4

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By salt stress, osmotic stress and metals. Down-regulated by abscisic acid (ABA).1 Publication

Gene expression databases

ExpressionAtlasiQ9LYB4 baseline and differential
GenevisibleiQ9LYB4 AT

Interactioni

Protein-protein interaction databases

BioGridi10797, 6 interactors
IntActiQ9LYB4, 6 interactors
STRINGi3702.AT3G63080.1

Structurei

3D structure databases

ProteinModelPortaliQ9LYB4
SMRiQ9LYB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
HOGENOMiHOG000277054
InParanoidiQ9LYB4
KOiK00432
OMAiMANECEG
OrthoDBiEOG09360NO2
PhylomeDBiQ9LYB4

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASSSSSVS EKSIHQFTVK DSSGKEVDLS VYQGKVLLVV NVASKCGFTE
60 70 80 90 100
SNYTQLTELY RKYKDQGFVV LAFPCNQFLS QEPGTSEEAH QFACTRFKAE
110 120 130 140 150
YPVFQKVRVN GQNAAPVYKF LKSKKPSFLG SRIKWNFTKF LVGKDGQVID
160 170
RYGTTVSPLS IQKDIEKALA QEL
Length:173
Mass (Da):19,327
Last modified:October 1, 2000 - v1
Checksum:iCE3F15979C150C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163816 Genomic DNA Translation: CAB87753.1
CP002686 Genomic DNA Translation: AEE80432.1
BT003821 mRNA Translation: AAO41874.1
BT005137 mRNA Translation: AAO50670.1
AY085116 mRNA Translation: AAM61670.1
PIRiT48097
RefSeqiNP_191867.1, NM_116173.4
UniGeneiAt.34000
At.43439

Genome annotation databases

EnsemblPlantsiAT3G63080.1; AT3G63080.1; AT3G63080
GeneIDi825483
GrameneiAT3G63080.1; AT3G63080.1; AT3G63080
KEGGiath:AT3G63080

Similar proteinsi

Entry informationi

Entry nameiGPX5_ARATH
AccessioniPrimary (citable) accession number: Q9LYB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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