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Protein

DNA (cytosine-5)-methyltransferase DRM1

Gene

DRM1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation.3 Publications

Miscellaneous

DRM2 is expressed at much higher levels than DRM1, which is scarcely detected, suggesting that DRM2 is the predominant de novo methylase.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

GO - Molecular functioni

  • DNA (cytosine-5-)-methyltransferase activity Source: TAIR
  • DNA binding Source: UniProtKB-KW

GO - Biological processi

  • defense response to fungus Source: TAIR
  • DNA methylation Source: TAIR
  • gene silencing Source: UniProtKB
  • histone H3-K9 methylation Source: TAIR
  • methylation-dependent chromatin silencing Source: TAIR

Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi4601 M.AthDRM2

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase DRM1 (EC:2.1.1.37)
Alternative name(s):
Protein DOMAINS REARRANGED METHYLASE 1
Gene namesi
Name:DRM1
Ordered Locus Names:At5g15380/At5g15370
ORF Names:F8M21.270/F8M21.260
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G15380
TAIRilocus:2150991 AT5G15380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003819411 – 624DNA (cytosine-5)-methyltransferase DRM1Add BLAST624

Proteomic databases

PaxDbiQ9LXE5
PRIDEiQ9LXE5

Expressioni

Gene expression databases

ExpressionAtlasiQ9LXE5 baseline and differential
GenevisibleiQ9LXE5 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G15380.1

Structurei

3D structure databases

ProteinModelPortaliQ9LXE5
SMRiQ9LXE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 100UBA 1PROSITE-ProRule annotationAdd BLAST44
Domaini108 – 149UBA 2PROSITE-ProRule annotationAdd BLAST42
Domaini188 – 231UBA 3PROSITE-ProRule annotationAdd BLAST44
Domaini291 – 622SAM-dependent MTase DRM-typePROSITE-ProRule annotationAdd BLAST332

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DRM-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGHW Eukaryota
ENOG410XQ4Y LUCA
HOGENOMiHOG000030355
InParanoidiQ9LXE5
OMAiEPMMILE
OrthoDBiEOG093605J3
PhylomeDBiQ9LXE5

Family and domain databases

InterProiView protein in InterPro
IPR001525 C5_MeTfrase
IPR029063 SAM-dependent_MTases
IPR030380 SAM_MeTfrase_DRM
IPR015940 UBA
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
PROSITEiView protein in PROSITE
PS51680 SAM_MT_DRM, 1 hit
PS50030 UBA, 2 hits

Sequencei

Sequence statusi: Complete.

Q9LXE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMSHIFLIS QIQEVEHGDS DDVNWNTDDD ELAIDNFQFS PSPVHISATS
60 70 80 90 100
PNSIQNRISD ETVASFVEMG FSTQMIARAI EETAGANMEP MMILETLFNY
110 120 130 140 150
SASTEASSSK SKVINHFIAM GFPEEHVIKA MQEHGDEDVG EITNALLTYA
160 170 180 190 200
EVDKLRESED MNININDDDD DNLYSLSSDD EEDELNNSSN EDRILQALIK
210 220 230 240 250
MGYLREDAAI AIERCGEDAS MEEVVDFICA AQMARQFDEI YAEPDKKELM
260 270 280 290 300
NNNKKRRTYT ETPRKPNTDQ LISLPKEMIG FGVPNHPGLM MHRPVPIPDI
310 320 330 340 350
ARGPPFFYYE NVAMTPKGVW AKISSHLYDI VPEFVDSKHF CAAARKRGYI
360 370 380 390 400
HNLPIQNRFQ IQPPQHNTIQ EAFPLTKRWW PSWDGRTKLN CLLTCIASSR
410 420 430 440 450
LTEKIREALE RYDGETPLDV QKWVMYECKK WNLVWVGKNK LAPLDADEME
460 470 480 490 500
KLLGFPRDHT RGGGISTTDR YKSLGNSFQV DTVAYHLSVL KPLFPNGINV
510 520 530 540 550
LSLFTGIGGG EVALHRLQIK MNVVVSVEIS DANRNILRSF WEQTNQKGIL
560 570 580 590 600
REFKDVQKLD DNTIERLMDE YGGFDLVIGG SPCNNLAGGN RHHRVGLGGE
610 620
HSSLFFDYCR ILEAVRRKAR HMRR
Length:624
Mass (Da):70,918
Last modified:September 1, 2009 - v2
Checksum:i9B3BBE10CAE68AB7
GO

Sequence cautioni

The sequence CAB89347 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g15370 and At5g15380.Curated
The sequence CAB89348 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g15370 and At5g15380.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353993 Genomic DNA Translation: CAB89347.1 Sequence problems.
AL353993 Genomic DNA Translation: CAB89348.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92154.1
AY530748 Genomic DNA Translation: AAS45433.1
PIRiT49972
T49973
RefSeqiNP_197042.2, NM_121542.3

Genome annotation databases

EnsemblPlantsiAT5G15380.1; AT5G15380.1; AT5G15380
GeneIDi831390
GrameneiAT5G15380.1; AT5G15380.1; AT5G15380
KEGGiath:AT5G15380

Similar proteinsi

Entry informationi

Entry nameiDRM1L_ARATH
AccessioniPrimary (citable) accession number: Q9LXE5
Secondary accession number(s): Q6QPM0, Q9LXE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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