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Entry version 117 (16 Jan 2019)
Sequence version 2 (31 May 2011)
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Protein

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Gene

FTA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.4 µM for CVIM substrate and for farnesyl transferase activity2 Publications
  2. KM=5.5 µM for CVIQ substrate and for farnesyl transferase activity2 Publications
  3. KM=6.9 µM for CVII substrate and for farnesyl transferase activity2 Publications
  4. KM=7.0 µM for CVIL substrate and for farnesyl transferase activity2 Publications
  5. KM=5.8 µM for CVIM substrate and for geranylgeranyl transferase activity2 Publications
  6. KM=3.5 µM for CVIQ substrate and for geranylgeranyl transferase activity2 Publications
  7. KM=19.0 µM for CVII substrate and for geranylgeranyl transferase activity2 Publications
  8. KM=17.2 µM for CVIL substrate and for geranylgeranyl transferase activity2 Publications

    pH dependencei

    Optimum pH is 7.9-8.5 for CTIL substrate and geranylgeranyl transferase activity.2 Publications

    Temperature dependencei

    Optimum temperature is 30-37 degrees Celsius for CTIL substrate and geranylgeranyl transferase activity.2 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionPrenyltransferase, Transferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:AT3G59380-MONOMER

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC:2.5.1.58, EC:2.5.1.59)
    Alternative name(s):
    CAAX farnesyltransferase subunit alpha
    FTase-alpha
    Ras proteins prenyltransferase subunit alpha
    Type I protein geranyl-geranyltransferase subunit alpha
    Short name:
    GGTase-I-alpha
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:FTA
    Ordered Locus Names:At3g59380
    ORF Names:F25L23.240
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT3G59380

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2081177 AT3G59380

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001197491 – 326Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaAdd BLAST326

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9LX33

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9LX33 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9LX33 AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer of an alpha and a beta subunit.

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    FTBQ389204EBI-1553317,EBI-1553332

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    10422, 7 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9LX33, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT3G59380.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9LX33

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9LX33

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati55 – 89PFTA 1Add BLAST35
    Repeati90 – 124PFTA 2Add BLAST35
    Repeati126 – 160PFTA 3Add BLAST35
    Repeati161 – 194PFTA 4Add BLAST34
    Repeati201 – 235PFTA 5Add BLAST35

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0530 Eukaryota
    COG5536 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000188957

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9LX33

    KEGG Orthology (KO)

    More...
    KOi
    K05955

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GDAKNYH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1527547at2759

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002088 Prenyl_trans_a

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01239 PPTA, 4 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51147 PFTA, 5 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9LX33-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MNFDETVPLS QRLEWSDVVP LTQDDGPNPV VPIAYKEEFR ETMDYFRAIY
    60 70 80 90 100
    FSDERSPRAL RLTEETLLLN SGNYTVWHFR RLVLEALNHD LFEELEFIER
    110 120 130 140 150
    IAEDNSKNYQ LWHHRRWVAE KLGPDVAGRE LEFTRRVLSL DAKHYHAWSH
    160 170 180 190 200
    RQWTLRALGG WEDELDYCHE LLEADVFNNS AWNQRYYVIT QSPLLGGLEA
    210 220 230 240 250
    MRESEVSYTI KAILTNPANE SSWRYLKALY KDDKESWISD PSVSSVCLNV
    260 270 280 290 300
    LSRTDCFHGF ALSTLLDLLC DGLRPTNEHK DSVRALANEE PETNLANLVC
    310 320
    TILGRVDPVR ANYWAWRKSK ITVAAI
    Length:326
    Mass (Da):37,985
    Last modified:May 31, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78146021EAFC785A
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAB91608 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti309V → I in AAC61853 (Ref. 1) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF064542 mRNA Translation: AAC61853.1
    AL356014 Genomic DNA Translation: CAB91608.1 Different initiation.
    CP002686 Genomic DNA Translation: AEE79914.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T49006
    T51811

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_567084.1, NM_115800.6

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    At.1520

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT3G59380.1; AT3G59380.1; AT3G59380

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    825107

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT3G59380.1; AT3G59380.1; AT3G59380

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT3G59380

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF064542 mRNA Translation: AAC61853.1
    AL356014 Genomic DNA Translation: CAB91608.1 Different initiation.
    CP002686 Genomic DNA Translation: AEE79914.1
    PIRiT49006
    T51811
    RefSeqiNP_567084.1, NM_115800.6
    UniGeneiAt.1520

    3D structure databases

    ProteinModelPortaliQ9LX33
    SMRiQ9LX33
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi10422, 7 interactors
    IntActiQ9LX33, 1 interactor
    STRINGi3702.AT3G59380.1

    Proteomic databases

    PaxDbiQ9LX33

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT3G59380.1; AT3G59380.1; AT3G59380
    GeneIDi825107
    GrameneiAT3G59380.1; AT3G59380.1; AT3G59380
    KEGGiath:AT3G59380

    Organism-specific databases

    AraportiAT3G59380
    TAIRilocus:2081177 AT3G59380

    Phylogenomic databases

    eggNOGiKOG0530 Eukaryota
    COG5536 LUCA
    HOGENOMiHOG000188957
    InParanoidiQ9LX33
    KOiK05955
    OMAiGDAKNYH
    OrthoDBi1527547at2759

    Enzyme and pathway databases

    BioCyciMetaCyc:AT3G59380-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q9LX33

    Gene expression databases

    ExpressionAtlasiQ9LX33 baseline and differential
    GenevisibleiQ9LX33 AT

    Family and domain databases

    InterProiView protein in InterPro
    IPR002088 Prenyl_trans_a
    PfamiView protein in Pfam
    PF01239 PPTA, 4 hits
    PROSITEiView protein in PROSITE
    PS51147 PFTA, 5 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFNTA_ARATH
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LX33
    Secondary accession number(s): O65346
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 31, 2011
    Last modified: January 16, 2019
    This is version 117 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
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