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Protein

L-lactate dehydrogenase

Gene

Os06g0104900

Organism
Oryza sativa subsp. japonica (Rice)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Os06g0104900), L-lactate dehydrogenase (OsJ_19824), L-lactate dehydrogenase (OJA1212_C06.25), L-lactate dehydrogenase (Os02g0105400)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Active sitei211Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-OSA-70268 Pyruvate metabolism
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Os06g0104900Imported
Ordered Locus Names:Os06g0104900Imported
ORF Names:OSNPB_060104900Imported, P0644B06.17Imported
OrganismiOryza sativa subsp. japonica (Rice)Imported
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

Expressioni

Gene expression databases

ExpressionAtlasiQ9LWZ6 differential

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g01590.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 178Ldh_1_NInterPro annotationAdd BLAST140
Domaini181 – 351Ldh_1_CInterPro annotationAdd BLAST171

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
KOiK00016
OMAiRQPGQTR
OrthoDBiEOG09360DKP

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LWZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKASSLSEL GFDADGPSFF RHLTLTDGDD GTLPRRRLIK ISVIGAGNVG
60 70 80 90 100
MAIAQTILTQ DLADEIVLID AVADKVRGEM LDLQHAAAFL PRVNIVSGTE
110 120 130 140 150
VSLTRSSDLV IVTAGARQIP GETRLNLLQR NVSLFRKIVP AAAEASPESV
160 170 180 190 200
LVIVSNPVDV LTYVAWKLSG FPASRVIGSG TNLDSSRFRF LLAEHLEVSA
210 220 230 240 250
QDVQAYMVGE HGDSSVALWS SISVGGMPVL AHLQKNHRSA ATAKKFDEAA
260 270 280 290 300
LEGIRRAVVG SAYEVIKLKG YTSWAIGYSV ASIAWSLLRD QRRIHPVSVL
310 320 330 340 350
AKGLVRGVPA DRELFLSLPA RLGRAGVLGV AAELVLTDEE ERRLRISAET
360
LWGYCHALGL
Length:360
Mass (Da):38,723
Last modified:October 1, 2000 - v1
Checksum:iD0A7F3ED2D382560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001129 Genomic DNA Translation: BAA90618.1
AP008212 Genomic DNA Translation: BAF18466.1
AK106504 mRNA Translation: BAG97743.1
AP014962 Genomic DNA Translation: BAS95736.1
RefSeqiXP_015642578.1, XM_015787092.1
UniGeneiOs.31913

Genome annotation databases

EnsemblPlantsiOs06t0104900-01; Os06t0104900-01; Os06g0104900
GeneIDi4339856
GrameneiOs06t0104900-01; Os06t0104900-01; Os06g0104900
KEGGiosa:4339856

Similar proteinsi

Entry informationi

Entry nameiQ9LWZ6_ORYSJ
AccessioniPrimary (citable) accession number: Q9LWZ6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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