B3 domain-containing transcription factor FUS3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: TAIR <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Seed-specific transcription factors ABI3 and FUS3: molecular interaction with DNA."
    Monke G., Altschmied L., Tewes A., Reidt W., Mock H.P., Baumlein H., Conrad U.
    Planta 219:158-166(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: TAIR <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes."
    Riechmann J.L., Heard J., Martin G., Reuber L., Jiang C., Keddie J., Adam L., Pineda O., Ratcliffe O.J., Samaha R.R., Creelman R., Pilgrim M., Broun P., Zhang J.Z., Ghandehari D., Sherman B.K., Yu G.
    Science 290:2105-2110(2000) [PubMed] [Europe PMC] [Abstract]
• kinase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.9

    "AKIN10 and FUSCA3 interact to control lateral organ development and phase transitions in Arabidopsis."
    Tsai A.Y., Gazzarrini S.
    Plant J. 69:809-821(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH KIN10, PHOSPHORYLATION, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

GO - Biological processⁱ

• embryo development ending in seed dormancy Source: TAIR <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "The ABSCISIC ACID-INSENSITIVE3, FUSCA3, and LEAFY COTYLEDON1 loci act in concert to control multiple aspects of Arabidopsis seed development."
    Parcy F., Valon C., Kohara A., Misera S., Giraudat J.
    Plant Cell 9:1265-1277(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gibberellin biosynthetic process Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.6

    "The transcription factor FUSCA3 controls developmental timing in Arabidopsis through the hormones gibberellin and abscisic acid."
    Gazzarrini S., Tsuchiya Y., Lumba S., Okamoto M., McCourt P.
    Dev. Cell 7:373-385(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• plant organ development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "AKIN10 and FUSCA3 interact to control lateral organ development and phase transitions in Arabidopsis."
    Tsai A.Y., Gazzarrini S.
    Plant J. 69:809-821(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH KIN10, PHOSPHORYLATION, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• positive regulation of abscisic acid-activated signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Overlapping and distinct roles of AKIN10 and FUSCA3 in ABA and sugar signaling during seed germination."
    Tsai A.Y., Gazzarrini S.
    Plant Signal. Behav. 7:1238-1242(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• positive regulation of abscisic acid biosynthetic process Source: TAIRInferred from mutant phenotypeⁱ
  • Ref.6

    "The transcription factor FUSCA3 controls developmental timing in Arabidopsis through the hormones gibberellin and abscisic acid."
    Gazzarrini S., Tsuchiya Y., Lumba S., Okamoto M., McCourt P.
    Dev. Cell 7:373-385(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• positive regulation of cell population proliferation Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "The transcription factor FUSCA3 controls developmental timing in Arabidopsis through the hormones gibberellin and abscisic acid."
    Gazzarrini S., Tsuchiya Y., Lumba S., Okamoto M., McCourt P.
    Dev. Cell 7:373-385(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• regulation of embryonic development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.11

    "SnRK1 phosphorylation of FUSCA3 positively regulates embryogenesis, seed yield, and plant growth at high temperature in Arabidopsis."
    Chan A., Carianopol C., Tsai A.Y., Varathanajah K., Chiu R.S., Gazzarrini S.
    J. Exp. Bot. 68:4219-4231(2017) [PubMed] [Europe PMC] [Abstract]

    Cited for: MUTAGENESIS OF SER-55; SER-56 AND SER-57, ACTIVITY REGULATION.
• response to auxin Source: TAIR <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.6

    "The transcription factor FUSCA3 controls developmental timing in Arabidopsis through the hormones gibberellin and abscisic acid."
    Gazzarrini S., Tsuchiya Y., Lumba S., Okamoto M., McCourt P.
    Dev. Cell 7:373-385(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• somatic embryogenesis Source: TAIRInferred from mutant phenotypeⁱ
  • "Leafy cotyledon genes are essential for induction of somatic embryogenesis of Arabidopsis."
    Gaj M.D., Zhang S., Harada J.J., Lemaux P.G.
    Planta 222:977-988(2005) [PubMed] [Europe PMC] [Abstract]
• vegetative to reproductive phase transition of meristem Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "AKIN10 and FUSCA3 interact to control lateral organ development and phase transitions in Arabidopsis."
    Tsai A.Y., Gazzarrini S.
    Plant J. 69:809-821(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH KIN10, PHOSPHORYLATION, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.9

    "AKIN10 and FUSCA3 interact to control lateral organ development and phase transitions in Arabidopsis."
    Tsai A.Y., Gazzarrini S.
    Plant J. 69:809-821(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH KIN10, PHOSPHORYLATION, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MMVDENVETK ASTLVASVDH GFGSGSGHDH HGLSASVPLL GVNWKKRRMP 
        60         70         80         90        100
RQRRSSSSFN LLSFPPPMPP ISHVPTPLPA RKIDPRKLRF LFQKELKNSD 
       110        120        130        140        150
VSSLRRMILP KKAAEAHLPA LECKEGIPIR MEDLDGFHVW TFKYRYWPNN 
       160        170        180        190        200
NSRMYVLENT GDFVNAHGLQ LGDFIMVYQD LYSNNYVIQA RKASEEEEVD 
       210        220        230        240        250
VINLEEDDVY TNLTRIENTV VNDLLLQDFN HHNNNNNNNS NSNSNKCSYY 
       260        270        280        290        300
YPVIDDVTTN TESFVYDTTA LTSNDTPLDF LGGHTTTTNN YYSKFGTFDG 
       310 
LGSVENISLD DFY                                         

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Arabidopsis thaliana
   Arabidopsis thaliana: entries and gene names
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references