Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 148 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Add a publicationFeedback
Protein

Uric acid degradation bifunctional protein TTL

Gene

TTL

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the last two steps of the degradation of uric acid, i.e. the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) and its stereoselective decarboxylation to (S)-allantoin. Might function as a negative regulator to modulate brassinosteroid-mediated plant growth.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: urate degradation

This protein is involved in step 2 and 3 of the subpathway that synthesizes (S)-allantoin from urate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uricase (C24_LOCUS8867), Urate oxidase (AXX17_At2g19490), Uricase (At2g26230), Uricase (AN1_LOCUS9015), Uricase (AXX17_At2g22060)
  2. Uric acid degradation bifunctional protein TTL (TTL)
  3. Uric acid degradation bifunctional protein TTL (TTL)
This subpathway is part of the pathway urate degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-allantoin from urate, the pathway urate degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei58Proton donor; for OHCU decarboxylase activity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei80Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylase, Hydrolase, Lyase, Multifunctional enzyme
Biological processPurine metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT5G58220-MONOMER
MetaCyc:AT5G58220-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.1.97, 399

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00394;UER00651
UPA00394;UER00652

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.35.1.3, the putative thyronine-transporting transthyretin (transthyretin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uric acid degradation bifunctional protein TTL
Alternative name(s):
Transthyretin-like protein
Including the following 2 domains:
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (EC:4.1.1.97)
Short name:
OHCU decarboxylase
5-hydroxyisourate hydrolase (EC:3.5.2.17)
Short name:
HIU hydrolase
Short name:
HIUHase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTL
Ordered Locus Names:At5g58220
ORF Names:MCK7.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G58220

The Arabidopsis Information Resource

More...
TAIRi
locus:2161208, AT5G58220

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000506062 – 324Uric acid degradation bifunctional protein TTLAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by BRI1 in vitro.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9LVM5

PRoteomics IDEntifications database

More...
PRIDEi
Q9LVM5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234627 [Q9LVM5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9LVM5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not regulated by plant steroids.

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9LVM5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9LVM5, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BRI1. Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
21178, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9LVM5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G58220.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9LVM5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9LVM5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 161OHCU decarboxylaseAdd BLAST160
Regioni58 – 59Substrate binding2
Regioni111 – 115Substrate binding5
Regioni178 – 324HIU hydrolaseAdd BLAST147

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal 29 amino acids are essential, but not sufficient, for the interaction with BRI1.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the OHCU decarboxylase family.Curated
In the C-terminal section; belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3006, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050809_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9LVM5

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPEGHYH

Database of Orthologous Groups

More...
OrthoDBi
1216648at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9LVM5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3330.10, 1 hit
2.60.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017129, HIU_hydrol/OHCU_decarb
IPR014306, Hydroxyisourate_hydrolase
IPR018020, OHCU_decarboxylase
IPR036778, OHCU_decarboxylase_sf
IPR023418, Thyroxine_BS
IPR000895, Transthyretin/HIU_hydrolase
IPR023416, Transthyretin/HIU_hydrolase_d
IPR036817, Transthyretin/HIU_hydrolase_sf
IPR023419, Transthyretin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10395, PTHR10395, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09349, OHCU_decarbox, 1 hit
PF00576, Transthyretin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037178, UCP037178_transthyretin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00189, TRNSTHYRETIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158694, SSF158694, 1 hit
SSF49472, SSF49472, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02962, hdxy_isourate, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00768, TRANSTHYRETIN_1, 1 hit
PS00769, TRANSTHYRETIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9LVM5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMEIGEDEW KVCCGSSEFA KQMSTSGPLT SQEAIYTARD IWFNQVNVTD
60 70 80 90 100
WLEAFSAHPQ IGNTPSPSIN SDFARRSVSE QSTAFATTSA SALQELAEWN
110 120 130 140 150
VLYKKKFGFI FIICASGRTH AEMLHALKER YENRPIVELE IAAMEQMKIT
160 170 180 190 200
ELRMAKLFSD KAKVISETDS SSSPVSTKPQ DRLRIIGGHL NVAAEAKAPK
210 220 230 240 250
RSRPPITTHV LDVSRGAPAA GVEVHLEVWS GTTGPSFVHG GGGVWSSVGT
260 270 280 290 300
SATDRDGRSG PLMDLVDALN PGTYRISFDT AKYSPGCFFP YVSIVFQVTE
310 320
SQKWEHFHVP LLLAPFSFST YRGS
Length:324
Mass (Da):35,564
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99191F450BDE262F
GO
Isoform 2 (identifier: Q9LVM5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-193: Missing.

Show »
Length:311
Mass (Da):34,149
Checksum:i00ED64B2F3754488
GO
Isoform 3 (identifier: Q9LVM5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-218: Missing.

Show »
Length:286
Mass (Da):31,511
Checksum:iC1B44222CCEF63D2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030135181 – 218Missing in isoform 3. CuratedAdd BLAST38
Alternative sequenceiVSP_030136181 – 193Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB019228 Genomic DNA Translation: BAA96913.1
CP002688 Genomic DNA Translation: AED97018.1
CP002688 Genomic DNA Translation: AED97019.1
CP002688 Genomic DNA Translation: AED97020.1
AY062771 mRNA Translation: AAL32849.1
AY081647 mRNA Translation: AAM10209.1
AK226943 mRNA Translation: BAE99013.1

NCBI Reference Sequences

More...
RefSeqi
NP_001032093.1, NM_001037016.2 [Q9LVM5-3]
NP_001032094.1, NM_001037017.3 [Q9LVM5-2]
NP_200630.1, NM_125207.5 [Q9LVM5-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G58220.1; AT5G58220.1; AT5G58220 [Q9LVM5-1]
AT5G58220.2; AT5G58220.2; AT5G58220 [Q9LVM5-3]
AT5G58220.3; AT5G58220.3; AT5G58220 [Q9LVM5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
835934

Gramene; a comparative resource for plants

More...
Gramenei
AT5G58220.1; AT5G58220.1; AT5G58220 [Q9LVM5-1]
AT5G58220.2; AT5G58220.2; AT5G58220 [Q9LVM5-3]
AT5G58220.3; AT5G58220.3; AT5G58220 [Q9LVM5-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G58220

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019228 Genomic DNA Translation: BAA96913.1
CP002688 Genomic DNA Translation: AED97018.1
CP002688 Genomic DNA Translation: AED97019.1
CP002688 Genomic DNA Translation: AED97020.1
AY062771 mRNA Translation: AAL32849.1
AY081647 mRNA Translation: AAM10209.1
AK226943 mRNA Translation: BAE99013.1
RefSeqiNP_001032093.1, NM_001037016.2 [Q9LVM5-3]
NP_001032094.1, NM_001037017.3 [Q9LVM5-2]
NP_200630.1, NM_125207.5 [Q9LVM5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q37X-ray2.50A1-161[»]
SMRiQ9LVM5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi21178, 5 interactors
IntActiQ9LVM5, 3 interactors
STRINGi3702.AT5G58220.1

Protein family/group databases

TCDBi9.B.35.1.3, the putative thyronine-transporting transthyretin (transthyretin) family

PTM databases

iPTMnetiQ9LVM5

Proteomic databases

PaxDbiQ9LVM5
PRIDEiQ9LVM5
ProteomicsDBi234627 [Q9LVM5-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
835934

Genome annotation databases

EnsemblPlantsiAT5G58220.1; AT5G58220.1; AT5G58220 [Q9LVM5-1]
AT5G58220.2; AT5G58220.2; AT5G58220 [Q9LVM5-3]
AT5G58220.3; AT5G58220.3; AT5G58220 [Q9LVM5-2]
GeneIDi835934
GrameneiAT5G58220.1; AT5G58220.1; AT5G58220 [Q9LVM5-1]
AT5G58220.2; AT5G58220.2; AT5G58220 [Q9LVM5-3]
AT5G58220.3; AT5G58220.3; AT5G58220 [Q9LVM5-2]
KEGGiath:AT5G58220

Organism-specific databases

AraportiAT5G58220
TAIRilocus:2161208, AT5G58220

Phylogenomic databases

eggNOGiKOG3006, Eukaryota
HOGENOMiCLU_050809_0_0_1
InParanoidiQ9LVM5
OMAiEPEGHYH
OrthoDBi1216648at2759
PhylomeDBiQ9LVM5

Enzyme and pathway databases

UniPathwayiUPA00394;UER00651
UPA00394;UER00652
BioCyciARA:AT5G58220-MONOMER
MetaCyc:AT5G58220-MONOMER
BRENDAi4.1.1.97, 399

Miscellaneous databases

EvolutionaryTraceiQ9LVM5

Protein Ontology

More...
PROi
PR:Q9LVM5

Gene expression databases

ExpressionAtlasiQ9LVM5, baseline and differential
GenevisibleiQ9LVM5, AT

Family and domain databases

Gene3Di1.10.3330.10, 1 hit
2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR017129, HIU_hydrol/OHCU_decarb
IPR014306, Hydroxyisourate_hydrolase
IPR018020, OHCU_decarboxylase
IPR036778, OHCU_decarboxylase_sf
IPR023418, Thyroxine_BS
IPR000895, Transthyretin/HIU_hydrolase
IPR023416, Transthyretin/HIU_hydrolase_d
IPR036817, Transthyretin/HIU_hydrolase_sf
IPR023419, Transthyretin_CS
PANTHERiPTHR10395, PTHR10395, 1 hit
PfamiView protein in Pfam
PF09349, OHCU_decarbox, 1 hit
PF00576, Transthyretin, 1 hit
PIRSFiPIRSF037178, UCP037178_transthyretin, 1 hit
PRINTSiPR00189, TRNSTHYRETIN
SUPFAMiSSF158694, SSF158694, 1 hit
SSF49472, SSF49472, 1 hit
TIGRFAMsiTIGR02962, hdxy_isourate, 1 hit
PROSITEiView protein in PROSITE
PS00768, TRANSTHYRETIN_1, 1 hit
PS00769, TRANSTHYRETIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTHL_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LVM5
Secondary accession number(s): Q2V2X6, Q2V2X7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 1, 2000
Last modified: December 2, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again