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Protein

ATPase 11, plasma membrane-type

Gene

AHA11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The plasma membrane H+ ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).By similarity

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3334-aspartylphosphate intermediateBy similarity1
Metal bindingi592MagnesiumBy similarity1
Metal bindingi596MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • proton-exporting ATPase activity, phosphorylative mechanism Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G62670-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase 11, plasma membrane-type (EC:7.1.2.1)
Alternative name(s):
Proton pump 11
Gene namesi
Name:AHA11
Ordered Locus Names:At5g62670
ORF Names:MRG21.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G62670
TAIRilocus:2172244 AT5G62670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65CytoplasmicSequence analysisAdd BLAST65
Transmembranei66 – 85Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini86 – 97ExtracellularSequence analysisAdd BLAST12
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 247CytoplasmicSequence analysisAdd BLAST129
Transmembranei248 – 268Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini269 – 277ExtracellularSequence analysis9
Transmembranei278 – 295Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini296 – 647CytoplasmicSequence analysisAdd BLAST352
Transmembranei648 – 669Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini670 – 674ExtracellularSequence analysis5
Transmembranei675 – 697Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini698 – 713CytoplasmicSequence analysisAdd BLAST16
Transmembranei714 – 734Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini735 – 759ExtracellularSequence analysisAdd BLAST25
Transmembranei760 – 780Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini781 – 792CytoplasmicSequence analysisAdd BLAST12
Transmembranei793 – 813Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini814 – 821ExtracellularSequence analysis8
Transmembranei822 – 842Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini843 – 956CytoplasmicSequence analysisAdd BLAST114

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462841 – 956ATPase 11, plasma membrane-typeAdd BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei889PhosphothreonineCombined sources1
Modified residuei938PhosphoserineBy similarity1
Modified residuei955PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LV11
PRIDEiQ9LV11

PTM databases

iPTMnetiQ9LV11

Expressioni

Gene expression databases

ExpressionAtlasiQ9LV11 baseline and differential
GenevisibleiQ9LV11 AT

Interactioni

Subunit structurei

Binds to 14-3-3 proteins. The binding is induced by phosphorylation of Thr-955. Binding to 14-3-3 proteins activates the H+-ATPase (By similarity).By similarity

Protein-protein interaction databases

BioGridi21631, 1 interactor
STRINGi3702.AT5G62670.1

Structurei

3D structure databases

ProteinModelPortaliQ9LV11
SMRiQ9LV11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni954 – 956Interaction with 14-3-3 proteinsBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0205 Eukaryota
COG0474 LUCA
HOGENOMiHOG000160005
InParanoidiQ9LV11
KOiK01535
OMAiAWEILGI
OrthoDBiEOG093601UL
PhylomeDBiQ9LV11

Family and domain databases

CDDicd02076 P-type_ATPase_H, 1 hit
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006534 P-type_ATPase_IIIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01647 ATPase-IIIA_H, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LV11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDKEEVLEA VLKETVDLEN VPIEEVFESL RCSREGLTTE AADERLALFG
60 70 80 90 100
HNKLEEKKES KFLKFLGFMW NPLSWVMEAA AIMAIALANG GGKPPDWQDF
110 120 130 140 150
VGIITLLVIN STISFIEENN AGNAAAALMA RLAPKAKVLR DGRWGEQDAA
160 170 180 190 200
ILVPGDIISI KLGDIVPADA RLLEGDPLKI DQSSLTGESL PVTKGPGDGV
210 220 230 240 250
YSGSTCKQGE LEAVVIATGV HTFFGKAAHL VDTTNHVGHF QQVLTAIGNF
260 270 280 290 300
CICSIAVGMI IEIVVMYPIQ HRAYRPGIDN LLVLLIGGIP IAMPTVLSVT
310 320 330 340 350
MAIGSHRLSQ QGAITKRMTA IEEMAGMDVL CSDKTGTLTL NKLTVDKNLI
360 370 380 390 400
EVFTKGVDAD TVVLMAAQAS RLENQDAIDA AIVGMLADPK EARAGVREVH
410 420 430 440 450
FLPFNPTDKR TALTYIDSDG KMHRVSKGAP EQILNLAHNR AEIERRVHAV
460 470 480 490 500
IDKFAERGLR SLAVAYQEVP EGTKESAGGP WQFMGLMPLF DPPRHDSAET
510 520 530 540 550
IRRALNLGVN VKMITGDQLA IGKETGRRLG MGTNMYPSSA LLGQHKDESI
560 570 580 590 600
GALPIDDLIE KADGFAGVFP EHKYEIVKRL QARKHICGMT GDGVNDAPAL
610 620 630 640 650
KKADIGIAVA DATDAARSAS DIVLTEPGLS VIISAVLTSR AIFQRMKNYT
660 670 680 690 700
IYAVSITIRI VLGFMLLALI WKFDFPPFMV LIIAILNDGT IMTISKDRVK
710 720 730 740 750
PSPLPDSWKL SEIFATGVVF GSYMAMMTVI FFWAAYKTDF FPRTFGVSTL
760 770 780 790 800
EKTAHDDFRK LASAIYLQVS IISQALIFVT RSRSWSYVER PGMLLVVAFI
810 820 830 840 850
LAQLVATLIA VYANWSFAAI EGIGWGWAGV IWLYNIVFYI PLDIIKFLIR
860 870 880 890 900
YALSGRAWDL VIEQRVAFTR QKDFGKEQRE LQWAHAQRTL HGLQAPDAKM
910 920 930 940 950
FPERTHFNEL SQMAEEAKRR AEIARLRELH TLKGHVESVV RLKGLDIETI

QQAYTV
Length:956
Mass (Da):105,123
Last modified:October 1, 2000 - v1
Checksum:iCA59212B16B9C5BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020751 Genomic DNA Translation: BAA97214.1
CP002688 Genomic DNA Translation: AED97641.1
AY125493 mRNA Translation: AAM78085.1
RefSeqiNP_201073.1, NM_125662.4
UniGeneiAt.28239
At.68527

Genome annotation databases

EnsemblPlantsiAT5G62670.1; AT5G62670.1; AT5G62670
GeneIDi836388
GrameneiAT5G62670.1; AT5G62670.1; AT5G62670
KEGGiath:AT5G62670

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020751 Genomic DNA Translation: BAA97214.1
CP002688 Genomic DNA Translation: AED97641.1
AY125493 mRNA Translation: AAM78085.1
RefSeqiNP_201073.1, NM_125662.4
UniGeneiAt.28239
At.68527

3D structure databases

ProteinModelPortaliQ9LV11
SMRiQ9LV11
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21631, 1 interactor
STRINGi3702.AT5G62670.1

PTM databases

iPTMnetiQ9LV11

Proteomic databases

PaxDbiQ9LV11
PRIDEiQ9LV11

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G62670.1; AT5G62670.1; AT5G62670
GeneIDi836388
GrameneiAT5G62670.1; AT5G62670.1; AT5G62670
KEGGiath:AT5G62670

Organism-specific databases

AraportiAT5G62670
TAIRilocus:2172244 AT5G62670

Phylogenomic databases

eggNOGiKOG0205 Eukaryota
COG0474 LUCA
HOGENOMiHOG000160005
InParanoidiQ9LV11
KOiK01535
OMAiAWEILGI
OrthoDBiEOG093601UL
PhylomeDBiQ9LV11

Enzyme and pathway databases

BioCyciARA:AT5G62670-MONOMER

Miscellaneous databases

PROiPR:Q9LV11

Gene expression databases

ExpressionAtlasiQ9LV11 baseline and differential
GenevisibleiQ9LV11 AT

Family and domain databases

CDDicd02076 P-type_ATPase_H, 1 hit
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006534 P-type_ATPase_IIIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01647 ATPase-IIIA_H, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPMA11_ARATH
AccessioniPrimary (citable) accession number: Q9LV11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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