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Protein

Probable acylpyruvase FAHD2, mitochondrial

Gene

FAHD2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable acylpyruvase. Binds copper in vitro.1 Publication

Catalytic activityi

A 3-acylpyruvate + H2O = a carboxylate + pyruvate.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Divalent metal cationBy similarity1
Metal bindingi69Divalent metal cationBy similarity1
Metal bindingi98Divalent metal cationBy similarity1

GO - Molecular functioni

  • acylpyruvate hydrolase activity Source: UniProtKB-EC
  • copper ion binding Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding

Enzyme and pathway databases

BioCyciARA:AT3G16700-MONOMER
ReactomeiR-ATH-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acylpyruvase FAHD2, mitochondrialCurated (EC:3.7.1.5Curated)
Alternative name(s):
Fumarylacetoacetate hydrolase domain-containing protein 2Curated
Short name:
FAH domain-containing protein 2Curated
Gene namesi
Name:FAHD2Curated
Ordered Locus Names:At3g16700Imported
ORF Names:MGL6.17Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G16700
TAIRilocus:2089373 AT3G16700

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000044205131 – 224Probable acylpyruvase FAHD2, mitochondrialAdd BLAST194

Proteomic databases

PaxDbiQ9LUR3
PRIDEiQ9LUR3

Expressioni

Gene expression databases

ExpressionAtlasiQ9LUR3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G16700.1

Structurei

3D structure databases

SMRiQ9LUR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1535 Eukaryota
COG0179 LUCA
HOGENOMiHOG000063753
KOiK01557
OMAiLSEMIWN
OrthoDBiEOG09360M9I

Family and domain databases

Gene3Di3.90.850.10, 1 hit
InterProiView protein in InterPro
IPR011234 Fumarylacetoacetase-like_C
IPR036663 Fumarylacetoacetase_C_sf
PfamiView protein in Pfam
PF01557 FAA_hydrolase, 1 hit
SUPFAMiSSF56529 SSF56529, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of EST are produced. According to EST sequences.Curated
Isoform 1 (identifier: Q9LUR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSMIQRLF KQGTKIVGVG LNYASHAKEL GNALPKDPIV FLKPTSSYLE
60 70 80 90 100
NGGTIEIPHP LDSLHHEVEL AVVIGQKARD VPERLAMNYI GGYALALDMT
110 120 130 140 150
ARELQVSAMA SGLPCTLAKG QDTFTPISSV LPKAMVLDPN NLELWLKVDD
160 170 180 190 200
ETRQKGWTKD MIFKVPYLIS YISSVMTLFK GDVILTGTPE GIGPVKIGQK
210 220
ITAGITGLSE VQFDVGRRLK PLLR
Length:224
Mass (Da):24,417
Last modified:October 1, 2000 - v1
Checksum:iF4518841E87F9571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022217 Genomic DNA Translation: BAB02762.1
CP002686 Genomic DNA Translation: AEE75853.1
AY087490 mRNA Translation: AAM65033.1
RefSeqiNP_188292.1, NM_112543.3 [Q9LUR3-1]
UniGeneiAt.38854

Genome annotation databases

EnsemblPlantsiAT3G16700.1; AT3G16700.1; AT3G16700 [Q9LUR3-1]
GeneIDi820922
GrameneiAT3G16700.1; AT3G16700.1; AT3G16700 [Q9LUR3-1]
KEGGiath:AT3G16700

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFAHD2_ARATH
AccessioniPrimary (citable) accession number: Q9LUR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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