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UniProtKB - Q9LU41 (ACA9_ARATH)
Protein
Calcium-transporting ATPase 9, plasma membrane-type
Gene
ACA9
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles.
By similarityCatalytic activityi
- EC:7.2.2.10
Activity regulationi
Activated by calmodulin.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 495 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 802 | MagnesiumBy similarity | 1 | |
Metal bindingi | 806 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled cation transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- calmodulin binding Source: TAIR
- metal ion binding Source: UniProtKB-KW
- P-type calcium transporter activity Source: TAIR
GO - Biological processi
- double fertilization forming a zygote and endosperm Source: TAIR
- pollen development Source: TAIR
Keywordsi
Molecular function | Calmodulin-binding, Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT3G21180-MONOMER |
Protein family/group databases
TCDBi | 3.A.3.2.14, the p-type atpase (p-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-transporting ATPase 9, plasma membrane-type (EC:7.2.2.10)Alternative name(s): Ca(2+)-ATPase isoform 9 |
Gene namesi | Name:ACA9 Ordered Locus Names:At3g21180 ORF Names:MXL8.3 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G21180 |
TAIRi | locus:2094726, AT3G21180 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: TAIR
Other locations
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 194 | CytoplasmicSequence analysisAdd BLAST | 194 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 233 | LumenalSequence analysisAdd BLAST | 18 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 382 | CytoplasmicSequence analysisAdd BLAST | 128 | |
Transmembranei | 383 – 402 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 403 – 439 | LumenalSequence analysisAdd BLAST | 37 | |
Transmembranei | 440 – 457 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 458 – 857 | CytoplasmicSequence analysisAdd BLAST | 400 | |
Transmembranei | 858 – 876 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 877 – 887 | LumenalSequence analysisAdd BLAST | 11 | |
Transmembranei | 888 – 908 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 909 – 928 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 929 – 951 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 952 – 963 | LumenalSequence analysisAdd BLAST | 12 | |
Transmembranei | 964 – 988 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 989 – 1006 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 1007 – 1028 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 1029 – 1038 | LumenalSequence analysis | 10 | |
Transmembranei | 1039 – 1060 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 1061 – 1086 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046415 | 1 – 1086 | Calcium-transporting ATPase 9, plasma membrane-typeAdd BLAST | 1086 |
Proteomic databases
PaxDbi | Q9LU41 |
PRIDEi | Q9LU41 |
ProteomicsDBi | 244562 |
PTM databases
iPTMneti | Q9LU41 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9LU41, baseline and differential |
Genevisiblei | Q9LU41, AT |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: TAIR
Protein-protein interaction databases
STRINGi | 3702.AT3G21180.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 57 – 68 | Interaction with calmodulinBy similarityAdd BLAST | 12 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 20 – 50 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Domaini
The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0204, Eukaryota |
HOGENOMi | CLU_002360_3_0_1 |
InParanoidi | Q9LU41 |
OMAi | HENHAHA |
OrthoDBi | 115892at2759 |
PhylomeDBi | Q9LU41 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR024750, Ca_ATPase_N_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF12515, CaATP_NAI, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9LU41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTSSSNGLL LTSMSGRHDD MEAGSAKTEE HSDHEELQHD PDDPFDIDNT
60 70 80 90 100
KNASVESLRR WRQAALVLNA SRRFRYTLDL NKEEHYDNRR RMIRAHAQVI
110 120 130 140 150
RAALLFKLAG EQQIAFGSST PAASTGNFDI DLEKLVSMTR NQNMSNLQQY
160 170 180 190 200
GGVKGVAEKL KSNMEQGINE DEKEVIDRKN AFGSNTYPKK KGKNFFMFLW
210 220 230 240 250
EAWQDLTLII LIIAAVTSLA LGIKTEGLKE GWLDGGSIAF AVLLVIVVTA
260 270 280 290 300
VSDYRQSLQF QNLNDEKRNI QLEVMRGGRT VKISIYDVVV GDVIPLRIGD
310 320 330 340 350
QVPADGVLIS GHSLAIDESS MTGESKIVHK DQKSPFLMSG CKVADGVGNM
360 370 380 390 400
LVTGVGINTE WGLLMASISE DTGEETPLQV RLNGLATFIG IVGLSVALVV
410 420 430 440 450
LVALLVRYFT GTTQDTNGAT QFIKGTTSIS DIVDDCVKIF TIAVTIVVVA
460 470 480 490 500
VPEGLPLAVT LTLAYSMRKM MADKALVRRL SACETMGSAT TICSDKTGTL
510 520 530 540 550
TLNQMTVVET YAGGSKMDVA DNPSGLHPKL VALISEGVAQ NTTGNIFHPK
560 570 580 590 600
DGGEVEISGS PTEKAILSWA YKLGMKFDTI RSESAIIHAF PFNSEKKRGG
610 620 630 640 650
VAVLRGDSEV FIHWKGAAEI VLACCTQYMD SNGTLQSIES QKEFFRVAID
660 670 680 690 700
SMAKNSLRCV AIACRTQELN QVPKEQEDLD KWALPEDELI LLAIVGIKDP
710 720 730 740 750
CRPGVREAVR ICTSAGVKVR MVTGDNLQTA KAIALECGIL SSDTEAVEPT
760 770 780 790 800
IIEGKVFREL SEKEREQVAK KITVMGRSSP NDKLLLVQAL RKNGDVVAVT
810 820 830 840 850
GDGTNDAPAL HEADIGLSMG ISGTEVAKES SDIIILDDNF ASVVKVVRWG
860 870 880 890 900
RSVYANIQKF IQFQLTVNVA ALIINVVAAM SSGDVPLKAV QLLWVNLIMD
910 920 930 940 950
TLGALALATE PPTDHLMHRT PVGRREPLIT NIMWRNLLVQ SFYQVAVLLV
960 970 980 990 1000
LNFAGLSILG LNHENHAHAV EVKNTMIFNA FVMCQIFNEF NARKPDEMNV
1010 1020 1030 1040 1050
FRGVNKNPLF VAIVGVTFIL QIIIVTFLGK FAHTVRLGWQ LWLASIIIGL
1060 1070 1080
VSWPLAIVGK LIPVPKTPMS VYFKKPFRKY KASRNA
Sequence cautioni
The sequence BAB01709 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023045 Genomic DNA Translation: BAB01709.1 Different initiation. CP002686 Genomic DNA Translation: AEE76473.1 AK227228 mRNA Translation: BAE99265.1 |
RefSeqi | NP_188755.2, NM_113013.5 |
Genome annotation databases
EnsemblPlantsi | AT3G21180.1; AT3G21180.1; AT3G21180 |
GeneIDi | 821671 |
Gramenei | AT3G21180.1; AT3G21180.1; AT3G21180 |
KEGGi | ath:AT3G21180 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023045 Genomic DNA Translation: BAB01709.1 Different initiation. CP002686 Genomic DNA Translation: AEE76473.1 AK227228 mRNA Translation: BAE99265.1 |
RefSeqi | NP_188755.2, NM_113013.5 |
3D structure databases
AlphaFoldDBi | Q9LU41 |
SMRi | Q9LU41 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT3G21180.1 |
Protein family/group databases
TCDBi | 3.A.3.2.14, the p-type atpase (p-atpase) superfamily |
PTM databases
iPTMneti | Q9LU41 |
Proteomic databases
PaxDbi | Q9LU41 |
PRIDEi | Q9LU41 |
ProteomicsDBi | 244562 |
Genome annotation databases
EnsemblPlantsi | AT3G21180.1; AT3G21180.1; AT3G21180 |
GeneIDi | 821671 |
Gramenei | AT3G21180.1; AT3G21180.1; AT3G21180 |
KEGGi | ath:AT3G21180 |
Organism-specific databases
Araporti | AT3G21180 |
TAIRi | locus:2094726, AT3G21180 |
Phylogenomic databases
eggNOGi | KOG0204, Eukaryota |
HOGENOMi | CLU_002360_3_0_1 |
InParanoidi | Q9LU41 |
OMAi | HENHAHA |
OrthoDBi | 115892at2759 |
PhylomeDBi | Q9LU41 |
Enzyme and pathway databases
BioCyci | ARA:AT3G21180-MONOMER |
Miscellaneous databases
PROi | PR:Q9LU41 |
Gene expression databases
ExpressionAtlasi | Q9LU41, baseline and differential |
Genevisiblei | Q9LU41, AT |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR024750, Ca_ATPase_N_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF12515, CaATP_NAI, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACA9_ARATH | |
Accessioni | Q9LU41Primary (citable) accession number: Q9LU41 Secondary accession number(s): Q0WUD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | June 26, 2007 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families