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Protein

Type IV inositol polyphosphate 5-phosphatase 6

Gene

IP5P6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has phosphatase activity toward PtdIns(4,5)P2 and PtdIns(3,4,5)P3 (PubMed:19473324). Required for the patterning of procambium and during the differentiation of vascular tissues. Acts before the acquisition of preprocambial identity. Seems to be also involved in the abscisic acid (ABA) signaling pathway (PubMed:10559439, PubMed:15100402). Acts redundantly with CVL1 for maintaining vascular continuity (PubMed:19363154, PubMed:25813544). Regulates phosphoinositide-dependent VAN3 localization (PubMed:19473324).5 Publications

Miscellaneous

CVP2 overexpression impairs protophloeme sieve element differentiation and overall root growth. Cvp1 and cvp2 double mutant displays high PtdIns(4,5)P2 levels.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.1 Publication
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.1 Publication

GO - Molecular functioni

  • inositol trisphosphate phosphatase activity Source: TAIR
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAbscisic acid signaling pathway, Differentiation

Enzyme and pathway databases

BioCyciARA:AT1G05470-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV inositol polyphosphate 5-phosphatase 6Curated (EC:3.1.3.361 Publication, EC:3.1.3.861 Publication)
Short name:
At5PTase6Curated
Alternative name(s):
Protein COTYLEDON VASCULAR PATTERN 21 Publication
Gene namesi
Name:IP5P6Curated
Synonyms:CVP21 Publication
Ordered Locus Names:At1g05470Imported
ORF Names:T25N20.12Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G05470
TAIRilocus:2201016 AT1G05470

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi543A → V in cvp2-2; induces an open vein network. 1 Publication1
Mutagenesisi575G → D in cvp2-1; induces an open vein network. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097241 – 617Type IV inositol polyphosphate 5-phosphatase 6Add BLAST617

Proteomic databases

PaxDbiQ9LR47
PRIDEiQ9LR47

Expressioni

Tissue specificityi

Broadly expressed in emerging organs. Mostly localized in procambium of growing organs. Restricted to vascular differentiating cells of young organs.2 Publications

Developmental stagei

During early stages of embryogenesis, broadly expressed throughout globular and torpedo stages. At late torpedo stage, strongly expressed in developing vascular cells and weakly expressed in surrounding cells. By the walking-stick stage, restricted to incipient vascular cells of the apical loop, the midvein of the cotyledon and the root vasculature. In emerging leaves, strongly expressed in procambium and weakly expressed in areole cells. Limited to developing vascular cells in later stage of leaf development. In roots, expressed in procambium of the elongating zone and in immature vascular cells of the root differentiation zone. During inflorescence development, broadly expressed in young floral buds, and gradually restricted to procambium of cauline leaves, sepals, petals, gynoecia and anthers.2 Publications

Gene expression databases

ExpressionAtlasiQ9LR47 baseline and differential
GenevisibleiQ9LR47 AT

Interactioni

Protein-protein interaction databases

BioGridi22290, 1 interactor
STRINGi3702.AT1G05470.1

Structurei

3D structure databases

ProteinModelPortaliQ9LR47
SMRiQ9LR47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni458 – 473Catalytic 1By similarityAdd BLAST16
Regioni538 – 553Catalytic 2By similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi236 – 333Ser-richAdd BLAST98

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
HOGENOMiHOG000241161
InParanoidiQ9LR47
OMAiSAHNRLK
OrthoDBiEOG0936064A
PhylomeDBiQ9LR47

Family and domain databases

Gene3Di3.60.10.10, 2 hits
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR000300 IPPc
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9LR47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREEKSKTNK LAWSKKMVRK WFNIKSKTEE FQADDPSSAG IEVEHRSSFS
60 70 80 90 100
AEKAPSTIKN TKTEKLSKNW EQQARQRRMN YENPRIIDVQ NYSIFVATWN
110 120 130 140 150
VAGRSPPSDL NLDEWLHSSA PADIYVLGFQ EIVPLNAGNV LGAEDNGPAQ
160 170 180 190 200
KWLSLIRKTL NNRPGTSGTS GYHTPSPIPV PMAELDADFS GSTRQKNSTF
210 220 230 240 250
FHRRSFQTPS STWNDPSIPQ PGLDRRFSVC DRVFFSHRPS DFDPSFRGSS
260 270 280 290 300
SSHRPSDYSR RPSDYSRRPS DYSRRPSDYS RRPSDSRPSD YSRPSDYYSR
310 320 330 340 350
PSDYSRPSDF SRSSDDDNGL GDSPSTVLYS PGSAANENGY RIPWNSSQYC
360 370 380 390 400
LVASKQMVGV FLTIWVKSEL REHVKNMKVS CVGRGLMGYL GNKGSISISM
410 420 430 440 450
LLHQTSFCFV CTHLTSGQKE GDELKRNSDV MEILKKTRFP RVKSSEEEKS
460 470 480 490 500
PENILQHDRV IWLGDLNYRI ALSYRSAKAL VEMQNWRALL ENDQLRIEQK
510 520 530 540 550
RGHVFKGWNE GKIYFPPTYK YSRNSDRYSG DDLHPKEKRR TPAWCDRILW
560 570 580 590 600
FGEGLHQLSY VRGESRFSDH RPVYGIFCAE VESAHNRIKR TTSYSASRVQ
610
AEELLPYSRG YTELSFF
Length:617
Mass (Da):70,853
Last modified:September 22, 2009 - v2
Checksum:iB4325EA5F3FE915C
GO
Isoform 2 (identifier: Q9LR47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-128: LDEWLHSSAPADIYVLG → MSGFIHQLLLISMYSGI

Note: May be due to a competing donor splice site. No experimental confirmation available.
Show »
Length:506
Mass (Da):57,931
Checksum:i3B1157FED3D22734
GO

Sequence cautioni

The sequence AAF79735 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BX816898 differs from that shown. Sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0379921 – 111Missing in isoform 2. CuratedAdd BLAST111
Alternative sequenceiVSP_037993112 – 128LDEWL…IYVLG → MSGFIHQLLLISMYSGI in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005106 Genomic DNA Translation: AAF79735.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27844.1
CP002684 Genomic DNA Translation: ANM59756.1
BX816898 mRNA No translation available.
RefSeqiNP_001322092.1, NM_001331550.1 [Q9LR47-1]
NP_172038.4, NM_100426.5 [Q9LR47-1]
UniGeneiAt.42397

Genome annotation databases

EnsemblPlantsiAT1G05470.1; AT1G05470.1; AT1G05470 [Q9LR47-1]
AT1G05470.2; AT1G05470.2; AT1G05470 [Q9LR47-1]
GeneIDi837048
GrameneiAT1G05470.1; AT1G05470.1; AT1G05470 [Q9LR47-1]
AT1G05470.2; AT1G05470.2; AT1G05470 [Q9LR47-1]
KEGGiath:AT1G05470

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005106 Genomic DNA Translation: AAF79735.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27844.1
CP002684 Genomic DNA Translation: ANM59756.1
BX816898 mRNA No translation available.
RefSeqiNP_001322092.1, NM_001331550.1 [Q9LR47-1]
NP_172038.4, NM_100426.5 [Q9LR47-1]
UniGeneiAt.42397

3D structure databases

ProteinModelPortaliQ9LR47
SMRiQ9LR47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22290, 1 interactor
STRINGi3702.AT1G05470.1

Proteomic databases

PaxDbiQ9LR47
PRIDEiQ9LR47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G05470.1; AT1G05470.1; AT1G05470 [Q9LR47-1]
AT1G05470.2; AT1G05470.2; AT1G05470 [Q9LR47-1]
GeneIDi837048
GrameneiAT1G05470.1; AT1G05470.1; AT1G05470 [Q9LR47-1]
AT1G05470.2; AT1G05470.2; AT1G05470 [Q9LR47-1]
KEGGiath:AT1G05470

Organism-specific databases

AraportiAT1G05470
TAIRilocus:2201016 AT1G05470

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
HOGENOMiHOG000241161
InParanoidiQ9LR47
OMAiSAHNRLK
OrthoDBiEOG0936064A
PhylomeDBiQ9LR47

Enzyme and pathway databases

BioCyciARA:AT1G05470-MONOMER

Miscellaneous databases

PROiPR:Q9LR47

Gene expression databases

ExpressionAtlasiQ9LR47 baseline and differential
GenevisibleiQ9LR47 AT

Family and domain databases

Gene3Di3.60.10.10, 2 hits
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR000300 IPPc
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIP5P6_ARATH
AccessioniPrimary (citable) accession number: Q9LR47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: September 22, 2009
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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