UniProtKB - Q9LQV2 (RDR1_ARATH)
RNA-dependent RNA polymerase 1
RDR1
Functioni
RNA-dependent direct polymerase involved in antiviral silencing. Required for the production of some small RNAs (mainly 21 and some 22 nucleotides) derived from the crucifer-infecting tobamovirus (TMV-cg). Required for turnip mosaic virus (TuMV) silencing and accumulation of viral siRNAs. Involved in cucumber mosaic virus (CMV) silencing. Required for the biogenesis of viral secondary siRNAs, process that follows the production of primary siRNAs derived from viral RNA replication. Specifically targets the positive-strand of the 3 RNA genomes of CMV and preferentially amplifies the 5'-terminal siRNAs of each viral genomic RNA. Not involved in the production of siRNAs derived from a single-stranded 336-nucleotide satellite RNA of CMV.
4 PublicationsCatalytic activityi
- EC:2.7.7.48
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: GO_Central
GO - Biological processi
- defense response Source: UniProtKB-KW
- positive regulation of posttranscriptional gene silencing Source: TAIR
- production of siRNA involved in gene silencing by small RNA Source: GO_Central
- production of siRNA involved in RNA interference Source: CACAO
- response to salicylic acid Source: TAIR
- response to virus Source: TAIR
- wax biosynthetic process Source: TAIR
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-binding, RNA-directed RNA polymerase, Transferase |
Biological process | Plant defense, RNA-mediated gene silencing |
Enzyme and pathway databases
BRENDAi | 2.7.7.48, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-dependent RNA polymerase 1 (EC:2.7.7.48)Short name: AtRDRP1 Alternative name(s): RNA-directed RNA polymerase 1 |
Gene namesi | Name:RDR1 Synonyms:RDRP1 Ordered Locus Names:At1g14790 ORF Names:F10B6.19 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G14790 |
TAIRi | locus:2006822, AT1G14790 |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000404672 | 1 – 1107 | RNA-dependent RNA polymerase 1Add BLAST | 1107 |
Proteomic databases
PaxDbi | Q9LQV2 |
PRIDEi | Q9LQV2 |
ProteomicsDBi | 235102 |
Expressioni
Inductioni
Gene expression databases
ExpressionAtlasi | Q9LQV2, baseline and differential |
Genevisiblei | Q9LQV2, AT |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0988, Eukaryota |
HOGENOMi | CLU_001366_3_0_1 |
InParanoidi | Q9LQV2 |
OMAi | HTPHIKH |
OrthoDBi | 63910at2759 |
PhylomeDBi | Q9LQV2 |
Family and domain databases
InterProi | View protein in InterPro IPR035979, RBD_domain_sf IPR007855, RNA-dep_RNA_pol_euk-typ |
PANTHERi | PTHR23079, PTHR23079, 1 hit |
Pfami | View protein in Pfam PF05183, RdRP, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MGKTIQVFGF PNGVSAEEVK KFLERLTGSG TVYAIKVRQP KKGGPRVYAI
60 70 80 90 100
VQFTSERHTR LIITAAAERL YYGRSYLKAF EVEQDIVPKP RASLHTISGL
110 120 130 140 150
KMFFGCQVST KKFLTLWSAQ DVCVSFGIGM RKLHFSFSWY QKDYRLELSY
160 170 180 190 200
ENIWQIDLHS PQGRSSKFLV IQVIGAPKIF EKEDQPINLL FGIMDFYSDG
210 220 230 240 250
SDEQWIRTTD FTSSSCIGQS TAFCLELPVH LNVPDFRENF ANYAEHRASS
260 270 280 290 300
FLIESGSSYS SNANTLVPVV DPPPGFSLPF EILFKLNTLV QNACLSGPAL
310 320 330 340 350
DLDFYRLLNQ KKYDRALIDH CLEKLFHLGE CCYEPAHWLR DEYKKWISKG
360 370 380 390 400
KLPLSPTISL DDGLVYMYRV QVTPARVYFS GPEVNVSNRV LRHYSKYINN
410 420 430 440 450
FLRVSFVDED LEKVRSMDLS PRSSTQRRTK LYDRIYSVLR DGIVIGDKKF
460 470 480 490 500
EFLAFSSSQL RENSAWMFAP IDRITAAHIR AWMGDFDHIR NVAKYAARLG
510 520 530 540 550
QSFSSSRETL NVRSDEIEVI PDVEIISLGT RYVFSDGIGK ISAEFARKVA
560 570 580 590 600
RKCGLTEFSP SAFQIRYGGY KGVVAVDPNS SKKLSLRKSM SKFESENTKL
610 620 630 640 650
DVLAWSKYQP CYMNRQLITL LSTLGVTDSV FEKKQREVVD RLDAILTHPL
660 670 680 690 700
EAHEALGLMA PGENTNILKA LILCGYKPDA EPFLSMMLQN FRASKLLELR
710 720 730 740 750
TKTRIFISGG RSMMGCLDET RTLEYGQVVV QYSDPMRPGR RFIITGPVVV
760 770 780 790 800
AKNPCLHPGD VRVLQAVNVP ALNHMVDCVV FPQKGLRPHP NECSGSDLDG
810 820 830 840 850
DIYFVCWDQE LVPPRTSEPM DYTPEPTQIL DHDVTIEEVE EYFANYIVND
860 870 880 890 900
SLGIIANAHT AFADKEPLKA FSDPCIELAK KFSTAVDFPK TGVAAVIPQH
910 920 930 940 950
LYVKEYPDFM EKPDKPTYES KNVIGKLFRE VKERAPPLIS IKSFTLDVAS
960 970 980 990 1000
KSYDKDMEVD GFEEYVDEAF YQKANYDFKL GNLMDYYGIK TEAEILSGGI
1010 1020 1030 1040 1050
MRMSKSFTKR RDAESIGRAV RALRKETLSL FNASEEEENE SAKASAWYHV
1060 1070 1080 1090 1100
TYHSSYWGLY NEGLNRDHFL SFAWCVYDKL VRIKKTNLGR RQRQETLERL
DHVLRFG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 758 | P → S in AAN64409 (PubMed:12650452).Curated | 1 | |
Sequence conflicti | 758 | P → S in CAA09894 (PubMed:9836747).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY148431 mRNA Translation: AAN64409.1 AC006917 Genomic DNA Translation: AAF79241.1 CP002684 Genomic DNA Translation: AEE29226.1 AK228731 mRNA Translation: BAF00633.1 AJ011977 Genomic DNA Translation: CAA09894.1 |
RefSeqi | NP_172932.1, NM_101348.4 |
Genome annotation databases
EnsemblPlantsi | AT1G14790.1; AT1G14790.1; AT1G14790 |
GeneIDi | 838044 |
Gramenei | AT1G14790.1; AT1G14790.1; AT1G14790 |
KEGGi | ath:AT1G14790 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY148431 mRNA Translation: AAN64409.1 AC006917 Genomic DNA Translation: AAF79241.1 CP002684 Genomic DNA Translation: AEE29226.1 AK228731 mRNA Translation: BAF00633.1 AJ011977 Genomic DNA Translation: CAA09894.1 |
RefSeqi | NP_172932.1, NM_101348.4 |
3D structure databases
AlphaFoldDBi | Q9LQV2 |
SMRi | Q9LQV2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT1G14790.1 |
Proteomic databases
PaxDbi | Q9LQV2 |
PRIDEi | Q9LQV2 |
ProteomicsDBi | 235102 |
Genome annotation databases
EnsemblPlantsi | AT1G14790.1; AT1G14790.1; AT1G14790 |
GeneIDi | 838044 |
Gramenei | AT1G14790.1; AT1G14790.1; AT1G14790 |
KEGGi | ath:AT1G14790 |
Organism-specific databases
Araporti | AT1G14790 |
TAIRi | locus:2006822, AT1G14790 |
Phylogenomic databases
eggNOGi | KOG0988, Eukaryota |
HOGENOMi | CLU_001366_3_0_1 |
InParanoidi | Q9LQV2 |
OMAi | HTPHIKH |
OrthoDBi | 63910at2759 |
PhylomeDBi | Q9LQV2 |
Enzyme and pathway databases
BRENDAi | 2.7.7.48, 399 |
Miscellaneous databases
PROi | PR:Q9LQV2 |
Gene expression databases
ExpressionAtlasi | Q9LQV2, baseline and differential |
Genevisiblei | Q9LQV2, AT |
Family and domain databases
InterProi | View protein in InterPro IPR035979, RBD_domain_sf IPR007855, RNA-dep_RNA_pol_euk-typ |
PANTHERi | PTHR23079, PTHR23079, 1 hit |
Pfami | View protein in Pfam PF05183, RdRP, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDR1_ARATH | |
Accessioni | Q9LQV2Primary (citable) accession number: Q9LQV2 Secondary accession number(s): Q8H1K9, Q9ZRX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 8, 2011 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families