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UniProtKB - Q9LPP4 (SMR1_ARATH)
Protein
Cyclin-dependent protein kinase inhibitor SMR1
Gene
SMR1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle (PubMed:17098811, PubMed:26546445).
Cooperates with SIM and SMR2 to promote endoreplication during leaf development (PubMed:26546445).
Specifically regulates endoreduplication in epidermal pavement cells to produce the cell size pattern (PubMed:20485493).
Is necessary for giant cell formation (PubMed:20485493).
Positive regulator of effector-triggered immunity (ETI) (PubMed:25455564).
1 Publication3 PublicationsMiscellaneous
Over-expression of SMR1 produces additional giant cells on sepals.1 Publication
GO - Molecular functioni
- protein kinase inhibitor activity Source: UniProtKB-KW
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- defense response to bacterium Source: TAIR
- negative regulation of mitotic nuclear division Source: GO_Central
- positive regulation of DNA endoreduplication Source: TAIR
- sepal giant cell development Source: TAIR
Keywordsi
Molecular function | Protein kinase inhibitor |
Biological process | Cell cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent protein kinase inhibitor SMR12 PublicationsAlternative name(s): Protein LOSS OF GIANT CELLS FROM ORGANS Protein SIAMESE-RELATED 12 Publications |
Gene namesi | Name:SMR12 Publications Synonyms:LGO Ordered Locus Names:At3g10525 ORF Names:F13M14.31, F18K10.10 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G10525 |
TAIRi | locus:505006334, AT3G10525 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Increased number of smaller cells and loss of giant cells in sepals due to both a decrease in endoreduplication and an average decrease in the duration of the cell cycle.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 62 | P → S in lgo-1; loss of giant cells in sepals. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000418064 | 1 – 128 | Cyclin-dependent protein kinase inhibitor SMR1Add BLAST | 128 |
Proteomic databases
PaxDbi | Q9LPP4 |
PTM databases
iPTMneti | Q9LPP4 |
Expressioni
Tissue specificityi
Expressed in roots, leaves, stems, siliques and flowers (PubMed:17098811). Expressed in the root elongation zone (PubMed:24399300).2 Publications
Inductioni
Up-regulated by double-stranded DNA breaks-inducing treatments (PubMed:17227549). Up-regulated by zeocin treatment (PubMed:21613568).2 Publications
Gene expression databases
ExpressionAtlasi | Q9LPP4, baseline and differential |
Genevisiblei | Q9LPP4, AT |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 5551, 10 interactors |
IntActi | Q9LPP4, 9 interactors |
STRINGi | 3702.AT3G10525.1 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 74 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 23 – 44 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 54 – 72 | Pro residuesSequence analysisAdd BLAST | 19 |
Phylogenomic databases
HOGENOMi | CLU_130615_0_0_1 |
InParanoidi | Q9LPP4 |
OMAi | IIMNREE |
OrthoDBi | 1569151at2759 |
PhylomeDBi | Q9LPP4 |
Family and domain databases
InterProi | View protein in InterPro IPR040389, SMR |
PANTHERi | PTHR33142, PTHR33142, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9LPP4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLELLQDLS KFNFPTPIKI RSKTSKTKKD EGDDDEDDLR CSTPTSQEHK
60 70 80 90 100
IPAVVDSPPP PPRKPRPPPS APSATAALMI RSCKRKLLVS TCEIIMNREE
110 120
IDRFFSSVYN ETSTTAKRRR SYPYCSRR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | R → S in AAM63322 (Ref. 5) Curated | 1 | |
Sequence conflicti | 54 | V → A in BAC42937 (PubMed:11910074).Curated | 1 | |
Sequence conflicti | 55 | V → I in AAM63322 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013428 Genomic DNA Translation: AAF76354.1 CP002686 Genomic DNA Translation: AEE74920.1 AK118323 mRNA Translation: BAC42937.1 BT024579 mRNA Translation: ABD38918.1 AY086115 mRNA Translation: AAM63322.1 |
RefSeqi | NP_566377.1, NM_111888.3 |
Genome annotation databases
EnsemblPlantsi | AT3G10525.1; AT3G10525.1; AT3G10525 |
GeneIDi | 820217 |
Gramenei | AT3G10525.1; AT3G10525.1; AT3G10525 |
KEGGi | ath:AT3G10525 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013428 Genomic DNA Translation: AAF76354.1 CP002686 Genomic DNA Translation: AEE74920.1 AK118323 mRNA Translation: BAC42937.1 BT024579 mRNA Translation: ABD38918.1 AY086115 mRNA Translation: AAM63322.1 |
RefSeqi | NP_566377.1, NM_111888.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 5551, 10 interactors |
IntActi | Q9LPP4, 9 interactors |
STRINGi | 3702.AT3G10525.1 |
PTM databases
iPTMneti | Q9LPP4 |
Proteomic databases
PaxDbi | Q9LPP4 |
Genome annotation databases
EnsemblPlantsi | AT3G10525.1; AT3G10525.1; AT3G10525 |
GeneIDi | 820217 |
Gramenei | AT3G10525.1; AT3G10525.1; AT3G10525 |
KEGGi | ath:AT3G10525 |
Organism-specific databases
Araporti | AT3G10525 |
TAIRi | locus:505006334, AT3G10525 |
Phylogenomic databases
HOGENOMi | CLU_130615_0_0_1 |
InParanoidi | Q9LPP4 |
OMAi | IIMNREE |
OrthoDBi | 1569151at2759 |
PhylomeDBi | Q9LPP4 |
Miscellaneous databases
PROi | PR:Q9LPP4 |
Gene expression databases
ExpressionAtlasi | Q9LPP4, baseline and differential |
Genevisiblei | Q9LPP4, AT |
Family and domain databases
InterProi | View protein in InterPro IPR040389, SMR |
PANTHERi | PTHR33142, PTHR33142, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SMR1_ARATH | |
Accessioni | Q9LPP4Primary (citable) accession number: Q9LPP4 Secondary accession number(s): Q8GXB8, Q8LDA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2012 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names