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Entry version 119 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

SKP1-like protein 4

Gene

ASK4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SKP1-like protein 4
Short name:
AtSK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASK4
Ordered Locus Names:At1g20140
ORF Names:T20H2.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT1G20140

The Arabidopsis Information Resource

More...
TAIRi
locus:2198621 AT1G20140

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003752451 – 163SKP1-like protein 4Add BLAST163

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9LNT9

PRoteomics IDEntifications database

More...
PRIDEi
Q9LNT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed in inflorescence and siliques, and, to a lower extent, in seedlings, roots, and stems.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected throughout the inflorescence at a higher level in the inflorescence meristem (IM) than in the young flower. Very strongly expressed in the valve, septum, and developing seed. Also present in pollen grains.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9LNT9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9LNT9 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).

Interacts with At1g56610, At1g67340, At3g62230, At3g59000, At4g27050, At1g55000, SKIP16 and SKIP32.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EID1Q8LEA84EBI-604085,EBI-687388

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
23843, 65 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1431 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1452 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1474 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1495 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4
CPX-1517 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1538 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1560 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1581 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4

Database of interacting proteins

More...
DIPi
DIP-34007N

Protein interaction database and analysis system

More...
IntActi
Q9LNT9, 29 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G20140.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9LNT9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 163Interaction with the F-box domain of F-box proteinsBy similarityAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1724 Eukaryota
COG5201 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172184

KEGG Orthology (KO)

More...
KOi
K03094

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENAWAGW

Database of Orthologous Groups

More...
OrthoDBi
1412723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9LNT9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016897 SKP1
IPR001232 SKP1-like
IPR036296 SKP1-like_dim_sf
IPR011333 SKP1/BTB/POZ_sf
IPR016072 Skp1_comp_dimer
IPR016073 Skp1_comp_POZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01466 Skp1, 1 hit
PF03931 Skp1_POZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00512 Skp1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF81382 SSF81382, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9LNT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAETKKMIIL KSSDGESFEI EEAVAVKSQT IKHMIEDDCA DNGIPLPNVT
60 70 80 90 100
GAILAKVIEY CKKHVEAAAE AGGDKDFYGS AENDELKNWD SEFVKVDQPT
110 120 130 140 150
LFDLILAANY LNIGGLLDLT CKAVADQMRG KTPEQMRAHF NIKNDYTPEE
160
EAEVRNENKW AFE
Length:163
Mass (Da):18,187
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B0AD6B569A5F932
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC022472 Genomic DNA Translation: AAF79899.1
CP002684 Genomic DNA Translation: AEE29943.1
AY058205 mRNA Translation: AAL25617.1
AY098980 mRNA Translation: AAM19990.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B86335

NCBI Reference Sequences

More...
RefSeqi
NP_564105.1, NM_101868.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G20140.1; AT1G20140.1; AT1G20140

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838604

Gramene; a comparative resource for plants

More...
Gramenei
AT1G20140.1; AT1G20140.1; AT1G20140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G20140

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022472 Genomic DNA Translation: AAF79899.1
CP002684 Genomic DNA Translation: AEE29943.1
AY058205 mRNA Translation: AAL25617.1
AY098980 mRNA Translation: AAM19990.1
PIRiB86335
RefSeqiNP_564105.1, NM_101868.5

3D structure databases

SMRiQ9LNT9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi23843, 65 interactors
ComplexPortaliCPX-1431 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1452 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1474 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1495 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4
CPX-1517 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1538 SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1560 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1581 SCF(TIR1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4
DIPiDIP-34007N
IntActiQ9LNT9, 29 interactors
STRINGi3702.AT1G20140.1

Proteomic databases

PaxDbiQ9LNT9
PRIDEiQ9LNT9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G20140.1; AT1G20140.1; AT1G20140
GeneIDi838604
GrameneiAT1G20140.1; AT1G20140.1; AT1G20140
KEGGiath:AT1G20140

Organism-specific databases

AraportiAT1G20140
TAIRilocus:2198621 AT1G20140

Phylogenomic databases

eggNOGiKOG1724 Eukaryota
COG5201 LUCA
HOGENOMiHOG000172184
KOiK03094
OMAiENAWAGW
OrthoDBi1412723at2759
PhylomeDBiQ9LNT9

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9LNT9

Gene expression databases

ExpressionAtlasiQ9LNT9 baseline and differential
GenevisibleiQ9LNT9 AT

Family and domain databases

InterProiView protein in InterPro
IPR016897 SKP1
IPR001232 SKP1-like
IPR036296 SKP1-like_dim_sf
IPR011333 SKP1/BTB/POZ_sf
IPR016072 Skp1_comp_dimer
IPR016073 Skp1_comp_POZ
PfamiView protein in Pfam
PF01466 Skp1, 1 hit
PF03931 Skp1_POZ, 1 hit
PIRSFiPIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTiView protein in SMART
SM00512 Skp1, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF81382 SSF81382, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASK4_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LNT9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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