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Entry version 144 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Retinoblastoma-related protein 1

Gene

RBR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate (PubMed:18064404, PubMed:21444209). Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation (PubMed:22307083). Plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate maintenance during organogenesis and gametogenesis (PubMed:16377572, PubMed:16815954, PubMed:19359496, PubMed:20525851, PubMed:20585548, PubMed:20683442, PubMed:22595674, PubMed:24285791, PubMed:25303364). Required during lateral organ production (PubMed:20525851). Also involved in controlling asymmetric divisions of stem cells in different stem cell niches (PubMed:22921914, PubMed:23104828, PubMed:24302889). Acts as negative regulator of cell proliferation during leaf and gametophytes development (PubMed:15201912, PubMed:16361519, PubMed:18976913). At later stages of development, restricts the progression through additional endocycles (PubMed:16361519). In the leaf, plays a role in the control of the mesophyll differentiation (PubMed:24118480). Another role is its implication in the regulation of imprinted genes. Acts together with MSI1 to repress the expression of MET1 during gametogenesis. This in turn activates expression of the imprinted genes FIS2 and FWA (PubMed:18700816). Regulates many genes of the polycomb repressive complex 2 (PRC2) (PubMed:18976913, PubMed:19704913, PubMed:20585548). Plays an important role in meiosis affecting different aspects of this complex process (PubMed:21217641). Functions as a positive regulator of the developmental switch from embryonic heterotrophic growth to autotrophic growth (PubMed:21693514). Interaction with mastrevirus RepA or nanovirus Clink protein disrupts the RBR/E2F interaction and releases the transcription of replicative enzymes needed by the virus by increasing the E2F DNA-binding activity (PubMed:16361519).23 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processCell cycle, Host-virus interaction, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinoblastoma-related protein 1
Short name:
AtRBR
Short name:
AtRBR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBR1
Synonyms:RBR
Ordered Locus Names:At3g12280
ORF Names:F28J15.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G12280

The Arabidopsis Information Resource

More...
TAIRi
locus:2082194 AT3G12280

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Plants are gametophytic lethals (PubMed:15201912). During meiosis, reduction in the formation of meiotic crossing-overs and a failure of chromosome synapsis, leading to a dramatic reduction in fertility (PubMed:21217641).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi849N → F: Abolishes interaction with HAT2. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003352521 – 1013Retinoblastoma-related protein 1Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei885PhosphoserineCombined sources1
Modified residuei898PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly phosphorylated by CDKA-1 during G1 to S phase transition. Once hyper-phosphorylated, becomes inactive and unable to interact with E2F.3 Publications
Ubiquitinated (Probable). Subject to proteasome-dependent degradation during sucrose starvation (PubMed:21444209).Curated1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9LKZ3

PRoteomics IDEntifications database

More...
PRIDEi
Q9LKZ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9LKZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in actively dividing cells. Detected in the shoot apical meristem, in young leaf primordia and in both sporophytic tissue and the megagametophyte.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed before and after fertilization (PubMed:15201912). During meiosis, found to localize along the chromosome axes during late G2/early leptotene. As prophase I progressed, a lower expression is detectable at zygotene then more reduced at pachytene. Not detected at later stages (PubMed:21217641).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

The polycomb repressive complex 2 (PRC2) containing MSI1, MEA, FIS2 and FIE repress the paternal RBR allele during pollen and seed development (PubMed:18976913). Down-regulated by TCP15 (PubMed:21992944).2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9LKZ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9LKZ3 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the begomovirus replication-associated protein (Rep) (PubMed:10880461), the nanovirus Clink protein (PubMed:17267511), the mastrevirus RepA protein, E2FA, E2FB and E2FC (PubMed:16361519, PubMed:18064404, PubMed:16055635, PubMed:20683442, PubMed:22307083).

Interacts with MSI1 through its Domain A (PubMed:18700816).

Interacts with ATPK1/S6K1 (PubMed:20683442).

Interacts with SCR (PubMed:22921914, PubMed:24302889).

Interacts with HAT2 (PubMed:24302889).

Interacts with FAMA (PubMed:25303364, PubMed:24571519).

Interacts with MYB124 and MYB88 (PubMed:24571519).

Component of a DREAM-like complex which modulates a variety of developmentally regulated genes and of the mitotic genes in proliferating and differentiated cells. Associates with MYB3R3 in both earlier and later stages of leaves development.

Interacts with MYB3R4 only at early stages of leaves development (PubMed:26069325).

12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
5742, 29 interactors

Database of interacting proteins

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DIPi
DIP-33046N

Protein interaction database and analysis system

More...
IntActi
Q9LKZ3, 17 interactors

Molecular INTeraction database

More...
MINTi
Q9LKZ3

STRING: functional protein association networks

More...
STRINGi
3702.AT3G12280.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni406 – 858PocketAdd BLAST453
Regioni406 – 607Domain AAdd BLAST202
Regioni608 – 727SpacerAdd BLAST120
Regioni728 – 858Domain BAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi719 – 722Poly-Gly4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the retinoblastoma protein (RB) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1010 Eukaryota
ENOG410XQF7 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000078660

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9LKZ3

KEGG Orthology (KO)

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KOi
K04681

Identification of Orthologs from Complete Genome Data

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OMAi
CCLEIIT

Database of Orthologous Groups

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OrthoDBi
113612at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9LKZ3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036915 Cyclin-like_sf
IPR002720 RB_A
IPR002719 RB_B
IPR015030 RB_C
IPR028309 RB_fam
IPR024599 RB_N
IPR015652 RBR

The PANTHER Classification System

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PANTHERi
PTHR13742 PTHR13742, 1 hit
PTHR13742:SF30 PTHR13742:SF30, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11934 DUF3452, 1 hit
PF01858 RB_A, 1 hit
PF01857 RB_B, 1 hit
PF08934 Rb_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01367 DUF3452, 1 hit
SM01368 RB_A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9LKZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEVQPPVTP PIEPNGKRSE ASLLDICEKV LSLDGSTCDE ALKLFTETKR
60 70 80 90 100
ILSASMSNIG SGTREEVERF WFAFILYSVK RLSVRKEADG LSVSGDNEFN
110 120 130 140 150
LCQILRALKL NIVDFFKELP QFVVKAGSVL GELYGADWEN RLQAKEVQAN
160 170 180 190 200
FVHLSLLSKY YKRGFREFFL TYDANAEKNS ANSSTYLLDS YRFGWLLFLA
210 220 230 240 250
LRNHAFSRFK DLVTCSNGVV SILAILIIHV PCRFRNFSIQ DSSRFVKKGD
260 270 280 290 300
KGVDLVASLC KIYDASEDEL RIVIDKANNL VETILKKKPS PASECQTDKL
310 320 330 340 350
DNIDPDGLTY FEDLLEETSI STSLITLEKD YYDGKGELDE RVFINEEDSL
360 370 380 390 400
LGSGSLSAGA VNITGVKRKI DALSSPARTF ISPLSPHKSP AAKTNGISGA
410 420 430 440 450
TKLAATPVST AMTTAKWLRT VISPLLPKPS PGLEHFLKSC DRDITNDVTR
460 470 480 490 500
RAHIILEAIF PNSSLGAQCG GGSLQAVDLM DDIWAEQRRL EACKLYYRVL
510 520 530 540 550
EAMCKAEAQI LHANNLNSLL TNERFHRCML ACSAELVLAT HKTITMLFPA
560 570 580 590 600
VLERTGITAF DLSKVIESFI RHEDSLPREL RRHLNSLEER LLESMVWEKG
610 620 630 640 650
SSMYNSLIVA RPSLALEINQ LGLLAEPMPS LDAIAALINF SDGANHASSV
660 670 680 690 700
QKHETCPGQN GGIRSPKRLC TDYRSILVER NSFTSPVKDR LLALGNVKSK
710 720 730 740 750
MLPPPLQSAF ASPTRPNPGG GGETCAETGI NIFFTKINKL AAVRINGMVE
760 770 780 790 800
RLQLSQQIRE SVYCFFQHVL AQRTSLLFSR HIDQIILCCF YGVAKISQMS
810 820 830 840 850
LTFREIIYNY RKQPQCKPLV FRSVYVDALQ CRRQGRIGPD HVDIITFYNE
860 870 880 890 900
IFIPAVKPLL VELGPVRNDR AVEANNKPEG QCPGSPKVSV FPSVPDMSPK
910 920 930 940 950
KVSAVHNVYV SPLRGSKMDA LISHSTKSYY ACVGESTHAY QSPSKDLSAI
960 970 980 990 1000
NNRLNNSSSN RKRTLNFDAE AGMVSDSMVA NSLNLQNQNQ NQNGSDASSS
1010
GGAAPLKTEP TDS
Length:1,013
Mass (Da):112,175
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3CD279ED508C263
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4J8Q4F4J8Q4_ARATH
Retinoblastoma-related 1
RBR1 ATRBR1, RB, RB1, RBR, RETINOBLASTOMA 1
1,012Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG51072 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB03137 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti628M → I in AAL07142 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF245395 mRNA Translation: AAF79146.1
AP002047 Genomic DNA Translation: BAB03137.1 Sequence problems.
AC069472 Genomic DNA Translation: AAG51072.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75179.1
AY056293 mRNA Translation: AAL07142.1
AY150438 mRNA Translation: AAN12980.1

NCBI Reference Sequences

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RefSeqi
NP_566417.3, NM_112064.5 [Q9LKZ3-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT3G12280.1; AT3G12280.1; AT3G12280 [Q9LKZ3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
820408

Gramene; a comparative resource for plants

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Gramenei
AT3G12280.1; AT3G12280.1; AT3G12280 [Q9LKZ3-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT3G12280

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245395 mRNA Translation: AAF79146.1
AP002047 Genomic DNA Translation: BAB03137.1 Sequence problems.
AC069472 Genomic DNA Translation: AAG51072.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75179.1
AY056293 mRNA Translation: AAL07142.1
AY150438 mRNA Translation: AAN12980.1
RefSeqiNP_566417.3, NM_112064.5 [Q9LKZ3-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi5742, 29 interactors
DIPiDIP-33046N
IntActiQ9LKZ3, 17 interactors
MINTiQ9LKZ3
STRINGi3702.AT3G12280.1

PTM databases

iPTMnetiQ9LKZ3

Proteomic databases

PaxDbiQ9LKZ3
PRIDEiQ9LKZ3

Genome annotation databases

EnsemblPlantsiAT3G12280.1; AT3G12280.1; AT3G12280 [Q9LKZ3-1]
GeneIDi820408
GrameneiAT3G12280.1; AT3G12280.1; AT3G12280 [Q9LKZ3-1]
KEGGiath:AT3G12280

Organism-specific databases

AraportiAT3G12280
TAIRilocus:2082194 AT3G12280

Phylogenomic databases

eggNOGiKOG1010 Eukaryota
ENOG410XQF7 LUCA
HOGENOMiHOG000078660
InParanoidiQ9LKZ3
KOiK04681
OMAiCCLEIIT
OrthoDBi113612at2759
PhylomeDBiQ9LKZ3

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9LKZ3

Gene expression databases

ExpressionAtlasiQ9LKZ3 baseline and differential
GenevisibleiQ9LKZ3 AT

Family and domain databases

InterProiView protein in InterPro
IPR036915 Cyclin-like_sf
IPR002720 RB_A
IPR002719 RB_B
IPR015030 RB_C
IPR028309 RB_fam
IPR024599 RB_N
IPR015652 RBR
PANTHERiPTHR13742 PTHR13742, 1 hit
PTHR13742:SF30 PTHR13742:SF30, 1 hit
PfamiView protein in Pfam
PF11934 DUF3452, 1 hit
PF01858 RB_A, 1 hit
PF01857 RB_B, 1 hit
PF08934 Rb_C, 1 hit
SMARTiView protein in SMART
SM01367 DUF3452, 1 hit
SM01368 RB_A, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBR1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LKZ3
Secondary accession number(s): Q93ZS5, Q9C7C9, Q9LHH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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