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Entry version 145 (11 Dec 2019)
Sequence version 1 (01 Oct 2000)
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Protein

ABC transporter C family member 3

Gene

ABCC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pump for glutathione S-conjugates. Mediates the transport of glutathione conjugates such as chlorodinitrobenzene-GS (DNB-GS), and of chlorophyll catabolites such as Bn-NCC-1. Transports also heavy metals such as cadmium (Cd).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2). EC:7.6.2.2

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Glutathione-conjugate transport is inhibited by decyl-glutathione and, to a lower extent, by GS-GS, but not by GSH. All transports are inhibited by vanadate.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=100 µM for DNB-GS (at pH 7.4 and 25 degrees Celsius)1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi675 – 682ATP 1PROSITE-ProRule annotation8
    Nucleotide bindingi1303 – 1310ATP 2PROSITE-ProRule annotation8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTranslocase
    Biological processTransport
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    ARA:AT3G13080-MONOMER

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    3.A.1.208.17 the atp-binding cassette (abc) superfamily

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    ABC transporter C family member 3 (EC:7.6.2.2)
    Short name:
    ABC transporter ABCC.3
    Short name:
    AtABCC3
    Alternative name(s):
    ATP-energized glutathione S-conjugate pump 3
    Glutathione S-conjugate-transporting ATPase 3
    Multidrug resistance-associated protein 3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ABCC3
    Synonyms:EST2, MRP3
    Ordered Locus Names:At3g13080
    ORF Names:MJG19.3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT3G13080

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2090029 AT3G13080

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei83 – 103HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei116 – 136HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei153 – 173HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei183 – 203HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei325 – 345HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei364 – 386HelicalPROSITE-ProRule annotationAdd BLAST23
    Transmembranei439 – 459HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei463 – 483HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei551 – 571HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei940 – 960HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei987 – 1007HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei1077 – 1097HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei1181 – 1201HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei1205 – 1225HelicalPROSITE-ProRule annotationAdd BLAST21

    Keywords - Cellular componenti

    Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002260741 – 1514ABC transporter C family member 3Add BLAST1514

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9LK64

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9LK64

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous.2 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By 1-chloro-2,4-dinitrobenzene (CDNB), primisulfuron (PS), aminotriazole, benoxacor, oxabetrinil and IRL 1803, and, to a lower extent, by cloquintocet, fenchlorazol and fluorazol.2 Publications

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9LK64 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9LK64 AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT3G13080.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9LK64

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini325 – 606ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST282
    Domaini640 – 863ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
    Domaini950 – 1232ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST283
    Domaini1271 – 1503ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1507 – 1512Poly-Ser6

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0054 Eukaryota
    COG1132 LUCA

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9LK64

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WEDGIEP

    Database of Orthologous Groups

    More...
    OrthoDBi
    138195at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9LK64

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.1560.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003593 AAA+_ATPase
    IPR011527 ABC1_TM_dom
    IPR036640 ABC1_TM_sf
    IPR003439 ABC_transporter-like
    IPR017871 ABC_transporter_CS
    IPR027417 P-loop_NTPase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00664 ABC_membrane, 2 hits
    PF00005 ABC_tran, 2 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00382 AAA, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 2 hits
    SSF90123 SSF90123, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50929 ABC_TM1F, 2 hits
    PS00211 ABC_TRANSPORTER_1, 1 hit
    PS50893 ABC_TRANSPORTER_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9LK64-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDFLGSTTGS GTLAMLFSFS ESILPLDSRS FLLKPLFLRW LSGFLHSVLL
    60 70 80 90 100
    LVLFFSWVRK KIRGDSGVTE SLKDRRDFGF KSALFCSLAL SLLNLVLMSL
    110 120 130 140 150
    SGFYWYESGW LDNEQLVSSL GFLLGMVSWG VLSICLHRCR DCEHKKAPFL
    160 170 180 190 200
    LRLWLVFYLV VSCYSLVVDF VMYERRETVP VHLLVFDIVA FIAAVFLGYV
    210 220 230 240 250
    AVLKKDRSNS NGVLEEPLLN GGDSRVGGDD SVELNKTNGS GEATPYSRAG
    260 270 280 290 300
    ILSLLTFSWM SPLIDIGNKK TLDLEDVPQL HDTDSVVGLA PKFRSMLESP
    310 320 330 340 350
    DGGERSGVTT FKLIKALYFT AQWEILVTAF FAFIYTVASY VGPALIDTFV
    360 370 380 390 400
    QYLNGRRQYN HEGYVLVITF FAAKIVECLS QRHWFFRLQK VGIRMRSALV
    410 420 430 440 450
    AMIYEKGLTL SCQSKQGRTS GEIINFMTVD AERIGNFSWY MHDPWMVLLQ
    460 470 480 490 500
    VGLALWILYR NLGLASIAAL VATIIVMLIN FPFGRMQERF QEKLMEAKDS
    510 520 530 540 550
    RMKSTSEILR NMRILKLQGW EMKFLSKIFD LRKSEEGWLK KYVYNSAVIS
    560 570 580 590 600
    FVFWGAPTLV SVSTFGACIL LGIPLESGKI LSALATFRIL QEPIYNLPDT
    610 620 630 640 650
    ISMIVQTKVS LDRLASYLCL DNLQPDIVER LPKGSSDVAV EVINSTLSWD
    660 670 680 690 700
    VSSSNPTLKD INFKVFPGMK VAVCGTVGSG KSSLLSSLLG EVPKVSGSLK
    710 720 730 740 750
    VCGTKAYVAQ SPWIQSGKIE DNILFGKPME RERYDKVLEA CSLSKDLEIL
    760 770 780 790 800
    SFGDQTVIGE RGINLSGGQK QRIQIARALY QDADIYLFDD PFSAVDAHTG
    810 820 830 840 850
    SHLFKEVLLG LLCSKSVIYV THQVEFLPAA DLILVMKDGR ISQAGKYNDI
    860 870 880 890 900
    LNSGTDFMEL IGAHQEALAV VDSVDANSVS EKSALGQENV IVKDAIAVDE
    910 920 930 940 950
    KLESQDLKND KLESVEPQRQ IIQEEEREKG SVALDVYWKY ITLAYGGALV
    960 970 980 990 1000
    PFILLGQVLF QLLQIGSNYW MAWATPVSED VQAPVKLSTL MIVYVALAFG
    1010 1020 1030 1040 1050
    SSLCILLRAT LLVTAGYKTA TELFHKMHHC IFRSPMSFFD STPSGRIMSR
    1060 1070 1080 1090 1100
    ASTDQSAVDL ELPYQFGSVA ITVIQLIGII GVMSQVSWLV FLVFIPVVAA
    1110 1120 1130 1140 1150
    SIWYQRYYIA AARELSRLVG VCKAPLIQHF SETISGATTI RSFSQEFRFR
    1160 1170 1180 1190 1200
    SDNMRLSDGY SRPKFYTAGA MEWLCFRLDM LSSLTFVFSL VFLVSIPTGV
    1210 1220 1230 1240 1250
    IDPSLAGLAV TYGLSLNTLQ AWLIWTLCNL ENKIISVERI LQYASVPSEP
    1260 1270 1280 1290 1300
    PLVIESNRPE QSWPSRGEVE IRDLQVRYAP HMPLVLRGIT CTFKGGLRTG
    1310 1320 1330 1340 1350
    IVGRTGSGKS TLIQTLFRIV EPSAGEIRID GVNILTIGLH DLRLRLSIIP
    1360 1370 1380 1390 1400
    QDPTMFEGTM RSNLDPLEEY TDDQIWEALD KCQLGDEVRK KEQKLDSSVS
    1410 1420 1430 1440 1450
    ENGDNWSMGQ RQLVCLGRVL LKRSKILVLD EATASVDTAT DNLIQKTLRE
    1460 1470 1480 1490 1500
    HFSDCTVITI AHRISSVIDS DMVLLLSNGI IEEYDTPVRL LEDKSSSFSK
    1510
    LVAEYTSRSS SSFD
    Length:1,514
    Mass (Da):168,971
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i455575FCD3DA5115
    GO
    Isoform 2 (identifier: Q9LK64-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1347-1372: SIIPQDPTMFEGTMRSNLDPLEEYTD → N

    Show »
    Length:1,489
    Mass (Da):166,103
    Checksum:i217F67BF2FBC405D
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1I9LTU2A0A1I9LTU2_ARATH
    Multidrug resistance-associated pro...
    ABCC3 ATMRP3, ATP-binding cassette C3, MJG19.26, MJG19_26, MULTIDRUG RESISTANCE PROTEIN 3
    1,510Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F4JB38F4JB38_ARATH
    Multidrug resistance-associated pro...
    ABCC3 ATMRP3, ATP-binding cassette C3, MJG19.26, MJG19_26, MULTIDRUG RESISTANCE PROTEIN 3
    1,120Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAC49791 differs from that shown. Reason: Frameshift.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0180991347 – 1372SIIPQ…EEYTD → N in isoform 2. CuratedAdd BLAST26

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U92650 mRNA Translation: AAC49791.1 Frameshift.
    AP000375 Genomic DNA Translation: BAB01399.1
    CP002686 Genomic DNA Translation: AEE75291.1
    CP002686 Genomic DNA Translation: AEE75292.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T52081

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_187915.1, NM_112147.3 [Q9LK64-1]
    NP_850575.1, NM_180244.1 [Q9LK64-2]

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT3G13080.1; AT3G13080.1; AT3G13080 [Q9LK64-1]
    AT3G13080.2; AT3G13080.2; AT3G13080 [Q9LK64-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    820496

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT3G13080.1; AT3G13080.1; AT3G13080 [Q9LK64-1]
    AT3G13080.2; AT3G13080.2; AT3G13080 [Q9LK64-2]

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT3G13080

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U92650 mRNA Translation: AAC49791.1 Frameshift.
    AP000375 Genomic DNA Translation: BAB01399.1
    CP002686 Genomic DNA Translation: AEE75291.1
    CP002686 Genomic DNA Translation: AEE75292.1
    PIRiT52081
    RefSeqiNP_187915.1, NM_112147.3 [Q9LK64-1]
    NP_850575.1, NM_180244.1 [Q9LK64-2]

    3D structure databases

    SMRiQ9LK64
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi3702.AT3G13080.1

    Protein family/group databases

    TCDBi3.A.1.208.17 the atp-binding cassette (abc) superfamily

    Proteomic databases

    PaxDbiQ9LK64
    PRIDEiQ9LK64

    Genome annotation databases

    EnsemblPlantsiAT3G13080.1; AT3G13080.1; AT3G13080 [Q9LK64-1]
    AT3G13080.2; AT3G13080.2; AT3G13080 [Q9LK64-2]
    GeneIDi820496
    GrameneiAT3G13080.1; AT3G13080.1; AT3G13080 [Q9LK64-1]
    AT3G13080.2; AT3G13080.2; AT3G13080 [Q9LK64-2]
    KEGGiath:AT3G13080

    Organism-specific databases

    AraportiAT3G13080
    TAIRilocus:2090029 AT3G13080

    Phylogenomic databases

    eggNOGiKOG0054 Eukaryota
    COG1132 LUCA
    InParanoidiQ9LK64
    OMAiWEDGIEP
    OrthoDBi138195at2759
    PhylomeDBiQ9LK64

    Enzyme and pathway databases

    BioCyciARA:AT3G13080-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q9LK64

    Gene expression databases

    ExpressionAtlasiQ9LK64 baseline and differential
    GenevisibleiQ9LK64 AT

    Family and domain databases

    Gene3Di1.20.1560.10, 2 hits
    InterProiView protein in InterPro
    IPR003593 AAA+_ATPase
    IPR011527 ABC1_TM_dom
    IPR036640 ABC1_TM_sf
    IPR003439 ABC_transporter-like
    IPR017871 ABC_transporter_CS
    IPR027417 P-loop_NTPase
    PfamiView protein in Pfam
    PF00664 ABC_membrane, 2 hits
    PF00005 ABC_tran, 2 hits
    SMARTiView protein in SMART
    SM00382 AAA, 2 hits
    SUPFAMiSSF52540 SSF52540, 2 hits
    SSF90123 SSF90123, 2 hits
    PROSITEiView protein in PROSITE
    PS50929 ABC_TM1F, 2 hits
    PS00211 ABC_TRANSPORTER_1, 1 hit
    PS50893 ABC_TRANSPORTER_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAB3C_ARATH
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LK64
    Secondary accession number(s): O24510, Q3EB73
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 1, 2000
    Last modified: December 11, 2019
    This is version 145 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
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