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Protein

Putative calcium-transporting ATPase 13, plasma membrane-type

Gene

ACA13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Enzyme regulationi

Activated by calmodulin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4494-aspartylphosphate intermediateBy similarity1
Metal bindingi747MagnesiumBy similarity1
Metal bindingi751MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: TAIR
  • calmodulin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Molecular functionCalmodulin-binding, Hydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G22910-MONOMER
ReactomeiR-ATH-418359 Reduction of cytosolic Ca++ levels
R-ATH-5578775 Ion homeostasis
R-ATH-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Putative calcium-transporting ATPase 13, plasma membrane-type (EC:3.6.3.8)
Alternative name(s):
Ca(2+)-ATPase isoform 13
Gene namesi
Name:ACA13
Ordered Locus Names:At3g22910
ORF Names:F5N5.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G22910
TAIRilocus:2084578 AT3G22910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 147CytoplasmicSequence analysisAdd BLAST147
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 186LumenalSequence analysisAdd BLAST18
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 336CytoplasmicSequence analysisAdd BLAST129
Transmembranei337 – 356HelicalSequence analysisAdd BLAST20
Topological domaini357 – 393LumenalSequence analysisAdd BLAST37
Transmembranei394 – 411HelicalSequence analysisAdd BLAST18
Topological domaini412 – 802CytoplasmicSequence analysisAdd BLAST391
Transmembranei803 – 821HelicalSequence analysisAdd BLAST19
Topological domaini822 – 832LumenalSequence analysisAdd BLAST11
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Topological domaini854 – 873CytoplasmicSequence analysisAdd BLAST20
Transmembranei874 – 896HelicalSequence analysisAdd BLAST23
Topological domaini897 – 905LumenalSequence analysis9
Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 944CytoplasmicSequence analysisAdd BLAST18
Transmembranei945 – 966HelicalSequence analysisAdd BLAST22
Topological domaini967 – 976LumenalSequence analysis10
Transmembranei977 – 998HelicalSequence analysisAdd BLAST22
Topological domaini999 – 1002CytoplasmicSequence analysis4

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464191 – 1017Putative calcium-transporting ATPase 13, plasma membrane-typeAdd BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9LIK7
PRIDEiQ9LIK7

PTM databases

iPTMnetiQ9LIK7

Expressioni

Gene expression databases

ExpressionAtlasiQ9LIK7 baseline and differential
GenevisibleiQ9LIK7 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi7195, 1 interactor
STRINGi3702.AT3G22910.1

Structurei

3D structure databases

ProteinModelPortaliQ9LIK7
SMRiQ9LIK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 31Interaction with calmodulinCuratedAdd BLAST12

Domaini

The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0204 Eukaryota
ENOG410XNNC LUCA
HOGENOMiHOG000265623
InParanoidiQ9LIK7
KOiK01537
OMAiREIQEDD
OrthoDBiEOG093601Z7
PhylomeDBiQ9LIK7

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LIK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNVSDHAE KKDKVGVEVL LELPKTLSKS NKKWQLALIK LYCSRTLLNC
60 70 80 90 100
AKHAIRKPGL FPRSLSYTAI DLDHHHGDDH FKIDTETLND LVKNKNQEKL
110 120 130 140 150
ESLGGPNGLV SALKSNTRLG INEEGDEIQR RRSTFGSNTY TRQPSKGLFH
160 170 180 190 200
FVVEAFKDLT ILILLGCATL SLGFGIKEHG LKEGWYDGGS IFVAVFLVVA
210 220 230 240 250
VSAVSNFRQN RQFDKLSKVS SNIKIDVVRN GRRQEISIFD IVVGDIVCLN
260 270 280 290 300
IGDQVPADGV FVEGHLLHVD ESSMTGESDH VEVSLTGNTF LFSGTKIADG
310 320 330 340 350
FGKMAVTSVG MNTAWGQMMS HISRDTNEQT PLQSRLDKLT SSIGKVGLLV
360 370 380 390 400
AFLVLLVLLI RYFTGTTKDE SGNREYNGKT TKSDEIVNAV VKMVAAAVTI
410 420 430 440 450
IVVAIPEGLP LAVTLTLAYS MKRMMKDNAM VRKLSACETM GSATVICTDK
460 470 480 490 500
TGTLTLNQMK VTDFWFGLES GKASSVSQRV VELFHQGVAM NTTGSVFKAK
510 520 530 540 550
AGTEYEFSGS PTEKAILSWA VEELEMGMEK VIEEHDVVHV EGFNSEKKRS
560 570 580 590 600
GVLMKKKGVN TENNVVHWKG AAEKILAMCS TFCDGSGVVR EMKEDDKIQF
610 620 630 640 650
EKIIQSMAAK SLRCIAFAYS EDNEDNKKLK EEKLSLLGII GIKDPCRPGV
660 670 680 690 700
KKAVEDCQFA GVNIKMITGD NIFTARAIAV ECGILTPEDE MNSEAVLEGE
710 720 730 740 750
KFRNYTQEER LEKVERIKVM ARSSPFDKLL MVKCLKELGH VVAVTGDGTN
760 770 780 790 800
DAPALKEADI GLSMGIQGTE VAKESSDIVI LDDNFASVAT VLKWGRCVYN
810 820 830 840 850
NIQKFIQFQL TVNVAALVIN FVAAVSAGDV PLTAVQLLWV NLIMDTLGAL
860 870 880 890 900
ALATEKPTND LMKKKPIGRV APLITNIMWR NLLAQAFYQI SVLLVLQFRG
910 920 930 940 950
RSIFNVTEKV KNTLIFNTFV LCQVFNEFNA RSLEKKNVFK GLHKNRLFIG
960 970 980 990 1000
IIVVTVVLQV VMVEFLKRFA DTERLNLGQW GVCIAIAAAS WPIGWLVKSV
1010
PVPERHFFSY LKWKKRS
Length:1,017
Mass (Da):112,528
Last modified:October 1, 2000 - v1
Checksum:i2F0265CCE8862916
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001300 Genomic DNA Translation: BAB03036.1
CP002686 Genomic DNA Translation: AEE76690.1
RefSeqiNP_188931.1, NM_113191.2
UniGeneiAt.65128

Genome annotation databases

EnsemblPlantsiAT3G22910.1; AT3G22910.1; AT3G22910
GeneIDi821863
GrameneiAT3G22910.1; AT3G22910.1; AT3G22910
KEGGiath:AT3G22910

Similar proteinsi

Entry informationi

Entry nameiACA13_ARATH
AccessioniPrimary (citable) accession number: Q9LIK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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