UniProtKB - Q9LHA8 (HS704_ARATH)
Heat shock 70 kDa protein 4
HSP70-4
Functioni
In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). ATP-dependent molecular chaperone that assists folding of unfolded or misfolded proteins under stress conditions. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the E3 ubiquitin-protein ligase CHIP. Recognizes specific sequence motifs in transit peptides and thereby led to precursor degradation through the ubiquitin-proteasome system. Plays a critical role in embryogenesis.
1 Publication1 PublicationIn cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions.
CuratedGO - Molecular functioni
- ATP binding Source: TAIR
- ATP hydrolysis activity Source: GO_Central
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protein folding chaperone Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
- unfolded protein binding Source: GO_Central
GO - Biological processi
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- protein refolding Source: GO_Central
- protein ubiquitination Source: UniProtKB
- response to bacterium Source: TAIR
- response to heat Source: UniProtKB
- response to temperature stimulus Source: TAIR
- response to virus Source: TAIR
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response, Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 70 kDa protein 41 PublicationAlternative name(s): Heat shock cognate 70 kDa protein 41 Publication Heat shock cognate protein 70-41 Publication Short name: AtHsc70-41 Publication Heat shock protein 70-41 Publication Short name: AtHsp70-41 Publication |
Gene namesi | Name:HSP70-41 Publication Synonyms:HSC70-41 Publication, HSP70, MED37_21 Publication, MED37C Ordered Locus Names:At3g12580Imported ORF Names:T16H11.7Imported, T2E22.11Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G12580 |
TAIRi | locus:2101222, AT3G12580 |
Subcellular locationi
Cell Wall
- plant-type cell wall Source: TAIR
Cytosol
- cytosol Source: TAIR
Golgi apparatus
- Golgi apparatus Source: TAIR
Mitochondrion
- mitochondrion Source: TAIR
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: TAIR
Vacuole
- plant-type vacuole Source: TAIR
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000397045 | 1 – 650 | Heat shock 70 kDa protein 4Add BLAST | 650 |
Proteomic databases
PaxDbi | Q9LHA8 |
PRIDEi | Q9LHA8 |
ProteomicsDBi | 238330 |
PTM databases
iPTMneti | Q9LHA8 |
MetOSitei | Q9LHA8 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
ExpressionAtlasi | Q9LHA8, baseline and differential |
Genevisiblei | Q9LHA8, AT |
Interactioni
Subunit structurei
GO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 5772, 29 interactors |
IntActi | Q9LHA8, 9 interactors |
MINTi | Q9LHA8 |
STRINGi | 3702.AT3G12580.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 620 – 650 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
HOGENOMi | CLU_005965_5_1_1 |
InParanoidi | Q9LHA8 |
OMAi | GCKVQNA |
OrthoDBi | 288077at2759 |
PhylomeDBi | Q9LHA8 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAGKGEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS
60 70 80 90 100
ERLIGDAAKN QVAMNPTNTV FDAKRLIGRR YSDPSVQADK SHWPFKVVSG
110 120 130 140 150
PGEKPMIVVN HKGEEKQFSA EEISSMVLIK MREIAEAFLG SPVKNAVVTV
160 170 180 190 200
PAYFNDSQRQ ATKDAGVISG LNVMRIINEP TAAAIAYGLD KKASSVGEKN
210 220 230 240 250
VLIFDLGGGT FDVSLLTIEE GIFEVKATAG DTHLGGEDFD NRMVNHFVQE
260 270 280 290 300
FKRKNKKDIT GNPRALRRLR TACERAKRTL SSTAQTTIEI DSLFEGIDFY
310 320 330 340 350
TTITRARFEE LNMDLFRKCM EPVEKCLRDA KMDKSSVHDV VLVGGSTRIP
360 370 380 390 400
KVQQLLQDFF NGKELCKSIN PDEAVAYGAA VQAAILSGEG NEKVQDLLLL
410 420 430 440 450
DVTPLSLGLE TAGGVMTVLI PRNTTIPTKK EQIFSTYSDN QPGVLIQVYE
460 470 480 490 500
GERARTKDNN LLGKFELSGI PPAPRGVPQI TVCFDIDANG ILNVSAEDKT
510 520 530 540 550
TGQKNKITIT NDKGRLSKEE IEKMVQEAEK YKAEDEEHKK KVDAKNALEN
560 570 580 590 600
YAYNMRNTIK DEKIASKLDA ADKKKIEDAI DQAIEWLDGN QLAEADEFED
610 620 630 640 650
KMKELESLCN PIIARMYQGA GPDMGGAGGM DDDTPAGGSG GAGPKIEEVD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 126 | M → I in CAA05547 (Ref. 1) Curated | 1 | |
Sequence conflicti | 149 | T → I in CAA05547 (Ref. 1) Curated | 1 | |
Sequence conflicti | 161 | A → G in CAA05547 (Ref. 1) Curated | 1 | |
Sequence conflicti | 342 | L → V in CAA05547 (Ref. 1) Curated | 1 | |
Sequence conflicti | 356 | L → V in CAA05547 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002551 mRNA Translation: CAA05547.1 AP002055 Genomic DNA Translation: BAB02269.1 AC069474 Genomic DNA Translation: AAG51030.1 CP002686 Genomic DNA Translation: AEE75218.1 AY054183 mRNA Translation: AAL06844.1 AY054190 mRNA Translation: AAL06851.1 AY059885 mRNA Translation: AAL24367.1 |
PIRi | JA0171 |
RefSeqi | NP_187864.1, NM_112093.3 |
Genome annotation databases
EnsemblPlantsi | AT3G12580.1; AT3G12580.1; AT3G12580 |
GeneIDi | 820438 |
Gramenei | AT3G12580.1; AT3G12580.1; AT3G12580 |
KEGGi | ath:AT3G12580 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002551 mRNA Translation: CAA05547.1 AP002055 Genomic DNA Translation: BAB02269.1 AC069474 Genomic DNA Translation: AAG51030.1 CP002686 Genomic DNA Translation: AEE75218.1 AY054183 mRNA Translation: AAL06844.1 AY054190 mRNA Translation: AAL06851.1 AY059885 mRNA Translation: AAL24367.1 |
PIRi | JA0171 |
RefSeqi | NP_187864.1, NM_112093.3 |
3D structure databases
AlphaFoldDBi | Q9LHA8 |
SMRi | Q9LHA8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 5772, 29 interactors |
IntActi | Q9LHA8, 9 interactors |
MINTi | Q9LHA8 |
STRINGi | 3702.AT3G12580.1 |
PTM databases
iPTMneti | Q9LHA8 |
MetOSitei | Q9LHA8 |
Proteomic databases
PaxDbi | Q9LHA8 |
PRIDEi | Q9LHA8 |
ProteomicsDBi | 238330 |
Genome annotation databases
EnsemblPlantsi | AT3G12580.1; AT3G12580.1; AT3G12580 |
GeneIDi | 820438 |
Gramenei | AT3G12580.1; AT3G12580.1; AT3G12580 |
KEGGi | ath:AT3G12580 |
Organism-specific databases
Araporti | AT3G12580 |
TAIRi | locus:2101222, AT3G12580 |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
HOGENOMi | CLU_005965_5_1_1 |
InParanoidi | Q9LHA8 |
OMAi | GCKVQNA |
OrthoDBi | 288077at2759 |
PhylomeDBi | Q9LHA8 |
Miscellaneous databases
PROi | PR:Q9LHA8 |
Gene expression databases
ExpressionAtlasi | Q9LHA8, baseline and differential |
Genevisiblei | Q9LHA8, AT |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HS704_ARATH | |
Accessioni | Q9LHA8Primary (citable) accession number: Q9LHA8 Secondary accession number(s): Q9ZS55 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families