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Protein

Cyclin-dependent kinase C-1

Gene

CDKC-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • leaf development Source: TAIR
  • protein phosphorylation Source: GO_Central
  • response to virus Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-674695 RNA Polymerase II Pre-transcription Events
R-ATH-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-ATH-6798695 Neutrophil degranulation
R-ATH-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase C-1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKC;1
Gene namesi
Name:CDKC-1
Ordered Locus Names:At5g10270
ORF Names:F18D22.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G10270
TAIRilocus:2145397 AT5G10270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931171 – 505Cyclin-dependent kinase C-1Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphotyrosineBy similarity1
Modified residuei198PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LFT8
PRIDEiQ9LFT8

PTM databases

iPTMnetiQ9LFT8

Expressioni

Tissue specificityi

Highly expressed in flowers. Expressed in seedlings, roots, rosettes and stems.1 Publication

Gene expression databases

ExpressionAtlasiQ9LFT8 baseline and differential
GenevisibleiQ9LFT8 AT

Interactioni

Subunit structurei

Interacts with CYCT1-3.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi16169, 10 interactors
IntActiQ9LFT8, 12 interactors
STRINGi3702.AT5G10270.1

Structurei

3D structure databases

ProteinModelPortaliQ9LFT8
SMRiQ9LFT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST300

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi417 – 493Gly-richAdd BLAST77

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0600 Eukaryota
ENOG410XPIR LUCA
HOGENOMiHOG000233024
InParanoidiQ9LFT8
KOiK08819
OMAiKDPTGCD
OrthoDBiEOG093607V4
PhylomeDBiQ9LFT8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LFT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMASFGQLN LEEPPPIWGS RSVDCFEKLE QIGEGTYGQV YMAKEIKTGE
60 70 80 90 100
IVALKKIRMD NEREGFPITA IREIKILKKL HHENVIQLKE IVTSPGRDRD
110 120 130 140 150
DQGKPDNNKY KGGIYMVFEY MDHDLTGLAD RPGLRFTVPQ IKCYMKQLLT
160 170 180 190 200
GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL ADFGLARSYS HDHTGNLTNR
210 220 230 240 250
VITLWYRPPE LLLGATKYGP AIDMWSVGCI FAELLHAKPI LPGKNEQEQL
260 270 280 290 300
NKIFELCGSP DEKLWPGVSK MPWFNNFKPA RPLKRRVREF FRHFDRHALE
310 320 330 340 350
LLEKMLVLDP AQRISAKDAL DAEYFWTDPL PCDPKSLPTY ESSHEFQTKK
360 370 380 390 400
KRQQQRQNEE AAKRQKLQHP PLQHSRLPPL QHGGQSHAAP HWPAGPNHPT
410 420 430 440 450
NNAPPQVPAG PSHNFYGKPR GPPGPNRYPP SGNQSGGYNQ SRGGYSSGSY
460 470 480 490 500
PPQGRGAPYV AGPRGPSGGP YGVGPPNYTQ GGQYGGSGSS GRGQNQRNQQ

YGWQQ
Length:505
Mass (Da):56,729
Last modified:October 1, 2000 - v1
Checksum:i9159218AEB976361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360334 Genomic DNA Translation: CAB96683.1
CP002688 Genomic DNA Translation: AED91515.1
AF375437 mRNA Translation: AAK53021.1
AY120690 mRNA Translation: AAM52233.1
PIRiT50815
RefSeqiNP_196589.1, NM_121065.3
UniGeneiAt.19998

Genome annotation databases

EnsemblPlantsiAT5G10270.1; AT5G10270.1; AT5G10270
GeneIDi830891
GrameneiAT5G10270.1; AT5G10270.1; AT5G10270
KEGGiath:AT5G10270

Similar proteinsi

Entry informationi

Entry nameiCDKC1_ARATH
AccessioniPrimary (citable) accession number: Q9LFT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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