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UniProtKB - Q9LES2 (UBA2A_ARATH)
Protein
UBP1-associated protein 2A
Gene
UBA2A
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as component of a complex regulating the turnover of mRNAs in the nucleus. Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs. May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus. However, unlike UBP1, UBA2A does not stimulate pre-mRNA splicing.
1 PublicationMiscellaneous
Plants over-expressing UB2A1 display severe growth defects consisting of premature cell death and chlorosis.1 Publication
GO - Molecular functioni
- mRNA 3'-UTR AU-rich region binding Source: TAIR
- mRNA binding Source: TAIR
GO - Biological processi
- abscisic acid-activated signaling pathway Source: TAIR
- cell death Source: TAIR
- defense response Source: TAIR
- ethylene biosynthetic process Source: TAIR
- leaf senescence Source: TAIR
- mRNA stabilization Source: TAIR
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: UBP1-associated protein 2AAlternative name(s): UBP1-interacting protein 2a |
Gene namesi | Name:UBA2A Ordered Locus Names:At3g56860 ORF Names:T8M16.190 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G56860 |
TAIRi | locus:2103670, AT3G56860 |
Subcellular locationi
Nucleus
- Nucleus 4 Publications
Note: Relocalizes into nuclear speckles in response to abscisic acid (ABA).
Nucleus
- nucleus Source: TAIR
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000425440 | 1 – 478 | UBP1-associated protein 2AAdd BLAST | 478 |
Proteomic databases
PaxDbi | Q9LES2 |
PRIDEi | Q9LES2 |
ProteomicsDBi | 228735 |
PTM databases
iPTMneti | Q9LES2 |
Expressioni
Tissue specificityi
Expressed in young leaves, flowers and embryos.1 Publication
Inductioni
By wounding.1 Publication
Gene expression databases
ExpressionAtlasi | Q9LES2, baseline and differential |
Genevisiblei | Q9LES2, AT |
Interactioni
Subunit structurei
Interacts with UBA1A, UBA2A, UBP1A, UBP1B, UBP1C and SRK2E.
2 PublicationsBinary interactionsi
Q9LES2
With | #Exp. | IntAct |
---|---|---|
UBA1A [Q9SHZ6] | 3 | EBI-346288,EBI-346271 |
Protein-protein interaction databases
BioGRIDi | 10169, 11 interactors |
IntActi | Q9LES2, 10 interactors |
STRINGi | 3702.AT3G56860.3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 140 – 217 | RRM 1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 245 – 328 | RRM 2PROSITE-ProRule annotationAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 99 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 321 – 359 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 442 – 478 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 24 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 43 – 74 | Acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 333 – 348 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 446 – 462 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0118, Eukaryota |
HOGENOMi | CLU_012062_1_6_1 |
InParanoidi | Q9LES2 |
OMAi | PGIGFNQ |
OrthoDBi | 1202220at2759 |
PhylomeDBi | Q9LES2 |
Family and domain databases
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9LES2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKKRKLEGE ESNEAEEPSQ KLKQTPEEEQ QLVIKNQDNQ GDVEEVEYEE
60 70 80 90 100
VEEEQEEEVE DDDDEDDGDE NEDQTDGNRI EAAATSGSGN QEDDDDEPIQ
110 120 130 140 150
DLLEPFSKEQ VLSLLKEAAE KHVDVANRIR EVADEDPVHR KIFVHGLGWD
160 170 180 190 200
TKTETLIEAF KQYGEIEDCK AVFDKISGKS KGYGFILYKS RSGARNALKQ
210 220 230 240 250
PQKKIGSRMT ACQLASKGPV FGGAPIAAAA VSAPAQHSNS EHTQKKIYVS
260 270 280 290 300
NVGAELDPQK LLMFFSKFGE IEEGPLGLDK YTGRPKGFCL FVYKSSESAK
310 320 330 340 350
RALEEPHKTF EGHILHCQKA IDGPKPGKQQ QHHHNPHAYN NPRYQRNDNN
360 370 380 390 400
GYGPPGGHGH LMAGNPAGMG GPTAQVINPA IGQALTALLA SQGAGLAFNP
410 420 430 440 450
AIGQALLGSL GTAAGVNPGN GVGMPTGYGT QAMAPGTMPG YGTQPGLQGG
460 470
YQTPQPGQGG TSRGQHGVGP YGTPYMGH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | N → D in AAK68825 (PubMed:14593172).Curated | 1 | |
Sequence conflicti | 90 | N → D in AAM10089 (PubMed:14593172).Curated | 1 | |
Sequence conflicti | 422 | V → D in BAH56834 (PubMed:19423640).Curated | 1 |
Sequence databases
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
AlphaFoldDBi | Q9LES2 |
SMRi | Q9LES2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 10169, 11 interactors |
IntActi | Q9LES2, 10 interactors |
STRINGi | 3702.AT3G56860.3 |
PTM databases
iPTMneti | Q9LES2 |
Proteomic databases
PaxDbi | Q9LES2 |
PRIDEi | Q9LES2 |
ProteomicsDBi | 228735 |
Genome annotation databases
Organism-specific databases
Araporti | AT3G56860 |
TAIRi | locus:2103670, AT3G56860 |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
HOGENOMi | CLU_012062_1_6_1 |
InParanoidi | Q9LES2 |
OMAi | PGIGFNQ |
OrthoDBi | 1202220at2759 |
PhylomeDBi | Q9LES2 |
Miscellaneous databases
PROi | PR:Q9LES2 |
Gene expression databases
ExpressionAtlasi | Q9LES2, baseline and differential |
Genevisiblei | Q9LES2, AT |
Family and domain databases
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | UBA2A_ARATH | |
Accessioni | Q9LES2Primary (citable) accession number: Q9LES2 Secondary accession number(s): C0Z2A5, Q94B29 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 19, 2014 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names