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Entry version 128 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

RAN GTPase-activating protein 1

Gene

RANGAP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Plays a role in spatial signaling during cell division.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cytokinesis by cell plate formation Source: TAIR
  • protein import into nucleus Source: TAIR

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RAN GTPase-activating protein 1
Short name:
AtRanGAP1
Short name:
RanGAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RANGAP1
Ordered Locus Names:At3g63130
ORF Names:T20O10.230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G63130

The Arabidopsis Information Resource

More...
TAIRi
locus:2099207 AT3G63130

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18 – 19WP → AA: Loss of nuclear envelope localization. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003472141 – 535RAN GTPase-activating protein 1Add BLAST535

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9LE82

PRoteomics IDEntifications database

More...
PRIDEi
Q9LE82

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9LE82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9LE82 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9LE82 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with WIP1 through its WPP domain.

Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3.

Interacts directly with WIT1, WIP2 and WIP3.

Interacts with POK1.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
10802, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-46423N

Protein interaction database and analysis system

More...
IntActi
Q9LE82, 7 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT3G63130.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9LE82

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati208 – 231LRR 1Add BLAST24
Repeati236 – 259LRR 2Add BLAST24
Repeati264 – 287LRR 3Add BLAST24
Repeati320 – 343LRR 4Add BLAST24
Repeati353 – 376LRR 5Add BLAST24
Repeati377 – 400LRR 6Add BLAST24
Repeati405 – 428LRR 7Add BLAST24
Repeati433 – 456LRR 8Add BLAST24
Repeati461 – 488LRR 9Add BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 115WPPAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi507 – 516Poly-Glu10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WPP domain is required for the nuclear envelope localization.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA1 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1909 Eukaryota
COG5238 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000241563

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9LE82

KEGG Orthology (KO)

More...
KOi
K14319

Identification of Orthologs from Complete Genome Data

More...
OMAi
FDSANQH

Database of Orthologous Groups

More...
OrthoDBi
1357476at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9LE82

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.246.200, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR025265 WPP_dom
IPR038214 WPP_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 4 hits
PF13943 WPP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9LE82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHSAKTTQN RVLSVKMWPP SKSTRLMLVE RMTKNITTPS IFSRKYGLLS
60 70 80 90 100
VEEAEQDAKR IEDLAFATAN KHFQNEPDGD GTSAVHVYAK ESSKLMLDVI
110 120 130 140 150
KRGPQEESEV EVSKDGDVFF DISGGSRAFI EEEEARDLLR PLADPRNSYT
160 170 180 190 200
KIRFSNRSFG SEAAKFAASV LSSIKDQLTE VDLSDFVAGR PEAEALEVMN
210 220 230 240 250
MFSSALEGSK LRYLNLSDNA LGEKGIRAFA SLINSQHDLE ELYLMNDGIS
260 270 280 290 300
EDAARAVREL LPSTDKIRVL QFHNNMTGDE GATAIAEIVR ECPSLEDFRC
310 320 330 340 350
SSTRIGSEGG VALAEALEHC SHLKKLDLRD NMFGVEGGIA LAKTLSVLTH
360 370 380 390 400
LTEIYMSYLN LEDEGTEALS EALLKSAPSL EVLELAGNDI TVKSTGNLAA
410 420 430 440 450
CIASKQSLAK LNLSENELKD EGTILIAKAV EGHDQLVEVD LSTNMIRRAG
460 470 480 490 500
ARALAQTVVK KNTFKLLNIN GNFISEEGID EVNDMFKDCL DKLVPLDDND
510 520 530
PEGEDFEDED EEEEGEDGNE LESKLGSLKI KQGEE
Length:535
Mass (Da):58,827
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06CA71980A007BEB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF214559 mRNA Translation: AAF25947.1
AL163816 Genomic DNA Translation: CAB87758.1
CP002686 Genomic DNA Translation: AEE80438.1
CP002686 Genomic DNA Translation: AEE80439.1
AY034918 mRNA Translation: AAK59425.1
AY150448 mRNA Translation: AAN12889.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T48102

NCBI Reference Sequences

More...
RefSeqi
NP_001190166.1, NM_001203237.1
NP_191872.1, NM_116178.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G63130.1; AT3G63130.1; AT3G63130
AT3G63130.2; AT3G63130.2; AT3G63130

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
825488

Gramene; a comparative resource for plants

More...
Gramenei
AT3G63130.1; AT3G63130.1; AT3G63130
AT3G63130.2; AT3G63130.2; AT3G63130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G63130

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214559 mRNA Translation: AAF25947.1
AL163816 Genomic DNA Translation: CAB87758.1
CP002686 Genomic DNA Translation: AEE80438.1
CP002686 Genomic DNA Translation: AEE80439.1
AY034918 mRNA Translation: AAK59425.1
AY150448 mRNA Translation: AAN12889.1
PIRiT48102
RefSeqiNP_001190166.1, NM_001203237.1
NP_191872.1, NM_116178.3

3D structure databases

SMRiQ9LE82
ModBaseiSearch...

Protein-protein interaction databases

BioGridi10802, 3 interactors
DIPiDIP-46423N
IntActiQ9LE82, 7 interactors
STRINGi3702.AT3G63130.2

PTM databases

iPTMnetiQ9LE82

Proteomic databases

PaxDbiQ9LE82
PRIDEiQ9LE82

Genome annotation databases

EnsemblPlantsiAT3G63130.1; AT3G63130.1; AT3G63130
AT3G63130.2; AT3G63130.2; AT3G63130
GeneIDi825488
GrameneiAT3G63130.1; AT3G63130.1; AT3G63130
AT3G63130.2; AT3G63130.2; AT3G63130
KEGGiath:AT3G63130

Organism-specific databases

AraportiAT3G63130
TAIRilocus:2099207 AT3G63130

Phylogenomic databases

eggNOGiKOG1909 Eukaryota
COG5238 LUCA
HOGENOMiHOG000241563
InParanoidiQ9LE82
KOiK14319
OMAiFDSANQH
OrthoDBi1357476at2759
PhylomeDBiQ9LE82

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9LE82

Gene expression databases

ExpressionAtlasiQ9LE82 baseline and differential
GenevisibleiQ9LE82 AT

Family and domain databases

Gene3Di1.10.246.200, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR025265 WPP_dom
IPR038214 WPP_sf
PfamiView protein in Pfam
PF13516 LRR_6, 4 hits
PF13943 WPP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAGP1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LE82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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