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Entry version 96 (16 Jan 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Protein SUPPRESSOR OF GENE SILENCING 3

Gene

SGS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for post-transcriptional gene silencing and natural virus resistance. May bind nucleic acids and is essential for the biogenesis of trans-acting siRNAs but is not required for silencing induced by IR-PTGS. Involved in the juvenile-to-adult transition regulation. In case of begomoviruses infection, it is targeted by the viral protein V2 leading to suppression of post-transcriptional gene silencing.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • defense response to virus Source: TAIR
  • production of ta-siRNAs involved in RNA interference Source: TAIR
  • regulation of defense response to virus Source: UniProtKB-KW
  • vegetative phase change Source: TAIR
  • viral process Source: UniProtKB-KW
  • virus induced gene silencing Source: TAIR
  • wax biosynthetic process Source: TAIR

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntiviral protein
Biological processHost-virus interaction, RNA-mediated gene silencing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SUPPRESSOR OF GENE SILENCING 3
Short name:
AtSGS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SGS3
Ordered Locus Names:At5g23570
ORF Names:MQM1.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G23570

The Arabidopsis Information Resource

More...
TAIRi
locus:2171716 AT5G23570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi500E → K in sgs3-3; complete suppression of post-transcriptional gene silencing. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003332891 – 625Protein SUPPRESSOR OF GENE SILENCING 3Add BLAST625

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9LDX1

PRoteomics IDEntifications database

More...
PRIDEi
Q9LDX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9LDX1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9LDX1 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with begomoviruses protein V2.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
17697, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-29658N

Protein interaction database and analysis system

More...
IntActi
Q9LDX1, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9LDX1

STRING: functional protein association networks

More...
STRINGi
3702.AT5G23570.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9LDX1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9LDX1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili452 – 533Sequence analysisAdd BLAST82
Coiled coili564 – 615Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 111Gly-richAdd BLAST37
Compositional biasi156 – 189Asp-richAdd BLAST34
Compositional biasi540 – 543Poly-Gln4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SGS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ73 Eukaryota
ENOG4111E45 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085166

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9LDX1

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPARQWH

Database of Orthologous Groups

More...
OrthoDBi
370807at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9LDX1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12266 RRM_like_XS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.2890, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005380 XS_domain
IPR038588 XS_domain_sf
IPR005381 Znf-XS_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03468 XS, 1 hit
PF03470 zf-XS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9LDX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRAGPMSK EKNVQGGYRP EVEQLVQGLA GTRLASSQDD GGEWEVISKK
60 70 80 90 100
NKNKPGNTSG KTWVSQNSNP PRAWGGQQQG RGSNVSGRGN NVSGRGNGNG
110 120 130 140 150
RGIQANISGR GRALSRKYDN NFVAPPPVSR PPLEGGWNWQ ARGGSAQHTA
160 170 180 190 200
VQEFPDVEDD VDNASEEEND SDALDDSDDD LASDDYDSDV SQKSHGSRKQ
210 220 230 240 250
NKWFKKFFGS LDSLSIEQIN EPQRQWHCPA CQNGPGAIDW YNLHPLLAHA
260 270 280 290 300
RTKGARRVKL HRELAEVLEK DLQMRGASVI PCGEIYGQWK GLGEDEKDYE
310 320 330 340 350
IVWPPMVIIM NTRLDKDDND KWLGMGNQEL LEYFDKYEAL RARHSYGPQG
360 370 380 390 400
HRGMSVLMFE SSATGYLEAE RLHRELAEMG LDRIAWGQKR SMFSGGVRQL
410 420 430 440 450
YGFLATKQDL DIFNQHSQGK TRLKFELKSY QEMVVKELRQ ISEDNQQLNY
460 470 480 490 500
FKNKLSKQNK HAKVLEESLE IMSEKLRRTA EDNRIVRQRT KMQHEQNREE
510 520 530 540 550
MDAHDRFFMD SIKQIHERRD AKEENFEMLQ QQERAKVVGQ QQQNINPSSN
560 570 580 590 600
DDCRKRAEEV SSFIEFQEKE MEEFVEEREM LIKDQEKKME DMKKRHHEEI
610 620
FDLEKEFDEA LEQLMYKHGL HNEDD
Length:625
Mass (Da):71,972
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i456E2A1396706A96
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8BE44A0A1P8BE44_ARATH
XS domain-containing protein / XS z...
SGS3 ATSGS3, MQM1.17, MQM1_17, SUPPRESSOR OF GENE SILENCING 3, At5g23570
501Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF239719 Genomic DNA Translation: AAF73960.1
AB025633 Genomic DNA Translation: BAA97244.1
CP002688 Genomic DNA Translation: AED93184.1
CP002688 Genomic DNA Translation: ANM69842.1
BT002944 mRNA Translation: AAO22757.1
BT004380 mRNA Translation: AAO42374.1

NCBI Reference Sequences

More...
RefSeqi
NP_001331491.1, NM_001343817.1
NP_197747.1, NM_122263.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
At.31001

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G23570.1; AT5G23570.1; AT5G23570
AT5G23570.3; AT5G23570.3; AT5G23570

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
832422

Gramene; a comparative resource for plants

More...
Gramenei
AT5G23570.1; AT5G23570.1; AT5G23570
AT5G23570.3; AT5G23570.3; AT5G23570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G23570

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239719 Genomic DNA Translation: AAF73960.1
AB025633 Genomic DNA Translation: BAA97244.1
CP002688 Genomic DNA Translation: AED93184.1
CP002688 Genomic DNA Translation: ANM69842.1
BT002944 mRNA Translation: AAO22757.1
BT004380 mRNA Translation: AAO42374.1
RefSeqiNP_001331491.1, NM_001343817.1
NP_197747.1, NM_122263.3
UniGeneiAt.31001

3D structure databases

ProteinModelPortaliQ9LDX1
SMRiQ9LDX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17697, 1 interactor
DIPiDIP-29658N
IntActiQ9LDX1, 2 interactors
MINTiQ9LDX1
STRINGi3702.AT5G23570.1

Proteomic databases

PaxDbiQ9LDX1
PRIDEiQ9LDX1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G23570.1; AT5G23570.1; AT5G23570
AT5G23570.3; AT5G23570.3; AT5G23570
GeneIDi832422
GrameneiAT5G23570.1; AT5G23570.1; AT5G23570
AT5G23570.3; AT5G23570.3; AT5G23570
KEGGiath:AT5G23570

Organism-specific databases

AraportiAT5G23570
TAIRilocus:2171716 AT5G23570

Phylogenomic databases

eggNOGiENOG410IQ73 Eukaryota
ENOG4111E45 LUCA
HOGENOMiHOG000085166
InParanoidiQ9LDX1
OMAiEPARQWH
OrthoDBi370807at2759
PhylomeDBiQ9LDX1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9LDX1

Gene expression databases

ExpressionAtlasiQ9LDX1 baseline and differential
GenevisibleiQ9LDX1 AT

Family and domain databases

CDDicd12266 RRM_like_XS, 1 hit
Gene3Di3.30.70.2890, 1 hit
InterProiView protein in InterPro
IPR005380 XS_domain
IPR038588 XS_domain_sf
IPR005381 Znf-XS_domain
PfamiView protein in Pfam
PF03468 XS, 1 hit
PF03470 zf-XS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGS3_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LDX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: January 16, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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