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Entry version 124 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Eukaryotic translation initiation factor 3 subunit A

Gene

TIF3A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit AUniRule annotation
Short name:
eIF3aUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 large subunit
Eukaryotic translation initiation factor 3 subunit 10UniRule annotation
eIF-3-thetaUniRule annotation
p114
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIF3A1
Ordered Locus Names:At4g11420
ORF Names:F25E4.40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G11420

The Arabidopsis Information Resource

More...
TAIRi
locus:2123076 AT4G11420

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001235401 – 987Eukaryotic translation initiation factor 3 subunit AAdd BLAST987

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9LD55

PRoteomics IDEntifications database

More...
PRIDEi
Q9LD55

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9LD55

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9LD55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9LD55 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9LD55 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. Binds to the translation initiation factor TIF3H1 (PubMed:15548739).

UniRule annotation1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MAF19.20F4K2102EBI-7217371,EBI-7216904

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
12045, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9LD55, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9LD55

STRING: functional protein association networks

More...
STRINGi
3702.AT4G11420.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini316 – 513PCIPROSITE-ProRule annotationAdd BLAST198

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili93 – 122UniRule annotationAdd BLAST30
Coiled coili556 – 742UniRule annotationAdd BLAST187
Coiled coili797 – 858UniRule annotationAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-3 subunit A family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2072 Eukaryota
ENOG410XQ37 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246822

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9LD55

KEGG Orthology (KO)

More...
KOi
K03254

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEVMYQT

Database of Orthologous Groups

More...
OrthoDBi
967904at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9LD55

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03000 eIF3a, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027512 EIF3A
IPR000717 PCI_dom

The PANTHER Classification System

More...
PANTHERi
PTHR14005 PTHR14005, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01399 PCI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00088 PINT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50250 PCI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9LD55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFAKPENA LKRADELINV GQKQDALQAL HDLITSKRYR AWQKPLEKIM
60 70 80 90 100
FKYLDLCVDL KRGRFAKDGL IQYRIVCQQV NVSSLEEVIK HFLHLATDKA
110 120 130 140 150
EQARSQADAL EEALDVDDLE ADRKPEDLQL SIVSGEKGKD RSDRELVTPW
160 170 180 190 200
FKFLWETYRT VLEILRNNSK LEALYAMTAH KAFQFCKQYK RTTEFRRLCE
210 220 230 240 250
IIRNHLANLN KYRDQRDRPD LSAPESLQLY LDTRFDQLKV ATELGLWQEA
260 270 280 290 300
FRSVEDIYGL MCMVKKTPKS SLLMVYYSKL TEIFWISSSH LYHAYAWFKL
310 320 330 340 350
FSLQKNFNKN LSQKDLQLIA SSVVLAALSI PPFDRAQSAS HMELENEKER
360 370 380 390 400
NLRMANLIGF NLEPKFEGKD MLSRSALLSE LVSKGVLSCA SQEVKDLFHV
410 420 430 440 450
LEHEFHPLDL GSKIQPLLEK ISKSGGKLSS APSLPEVQLS QYVPSLEKLA
460 470 480 490 500
TLRLLQQVSK IYQTIRIESL SQLVPFFQFS EVEKISVDAV KNNFVAMKVD
510 520 530 540 550
HMKGVVIFGN LGIESDGLRD HLAVFAESLS KVRAMLYPVP SKASKLAGVI
560 570 580 590 600
PNLADTVEKE HKRLLARKSI IEKRKEDQER QQLEMEREEE QKRLKLQKLT
610 620 630 640 650
EEAEQKRLAA ELAERRKQRI LREIEEKELE EAQALLEETE KRMKKGKKKP
660 670 680 690 700
LLDGEKVTKQ SVKERALTEQ LKERQEMEKK LQKLAKTMDY LERAKREEAA
710 720 730 740 750
PLIEAAYQRR LVEEREFYER EQQREVELSK ERHESDLKEK NRLSRMLGNK
760 770 780 790 800
EIFQAQVISR RQAEFDRIRT EREERISKII REKKQERDIK RKQIYYLKIE
810 820 830 840 850
EERIRKLQEE EEARKQEEAE RLKKVEAERK ANLDKAFEKQ RQREIELEEK
860 870 880 890 900
SRREREELLR GTNAPPARLA EPTVTPVGTT APAAAAAAAG APAAPYVPKW
910 920 930 940 950
KRQTTEVSGP SAPTSSETDR RSNRGPPPGD DHWGSNRGAA QNTDRWTSNR
960 970 980
ERSGPPAEGG DRWGSGPRGS DDRRSTFGSS RPRPTQR
Length:987
Mass (Da):114,300
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF38BA715209D55FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF291711 mRNA Translation: AAG53635.1
AL050399 Genomic DNA Translation: CAB82147.1
AL161531 Genomic DNA Translation: CAB81243.1
CP002687 Genomic DNA Translation: AEE83010.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T10562

NCBI Reference Sequences

More...
RefSeqi
NP_192881.1, NM_117213.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G11420.1; AT4G11420.1; AT4G11420

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
826746

Gramene; a comparative resource for plants

More...
Gramenei
AT4G11420.1; AT4G11420.1; AT4G11420

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G11420

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291711 mRNA Translation: AAG53635.1
AL050399 Genomic DNA Translation: CAB82147.1
AL161531 Genomic DNA Translation: CAB81243.1
CP002687 Genomic DNA Translation: AEE83010.1
PIRiT10562
RefSeqiNP_192881.1, NM_117213.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi12045, 5 interactors
IntActiQ9LD55, 1 interactor
MINTiQ9LD55
STRINGi3702.AT4G11420.1

PTM databases

iPTMnetiQ9LD55
SwissPalmiQ9LD55

Proteomic databases

PaxDbiQ9LD55
PRIDEiQ9LD55

Genome annotation databases

EnsemblPlantsiAT4G11420.1; AT4G11420.1; AT4G11420
GeneIDi826746
GrameneiAT4G11420.1; AT4G11420.1; AT4G11420
KEGGiath:AT4G11420

Organism-specific databases

AraportiAT4G11420
TAIRilocus:2123076 AT4G11420

Phylogenomic databases

eggNOGiKOG2072 Eukaryota
ENOG410XQ37 LUCA
HOGENOMiHOG000246822
InParanoidiQ9LD55
KOiK03254
OMAiLEVMYQT
OrthoDBi967904at2759
PhylomeDBiQ9LD55

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9LD55

Gene expression databases

ExpressionAtlasiQ9LD55 baseline and differential
GenevisibleiQ9LD55 AT

Family and domain databases

HAMAPiMF_03000 eIF3a, 1 hit
InterProiView protein in InterPro
IPR027512 EIF3A
IPR000717 PCI_dom
PANTHERiPTHR14005 PTHR14005, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEIF3A_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LD55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. Translation initiation factors
    List of translation initiation factor entries
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