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Protein

Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1, chloroplastic

Gene

CRD1

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis under oxygen- and copper-deficient conditions. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).2 Publications

Catalytic activityi

Magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide + 3 NADP+ + 5 H2O.

Cofactori

Fe cationBy similarity

Pathwayi: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processChlorophyll biosynthesis, Photosynthesis
LigandIron, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.14.13.81 1318
UniPathwayiUPA00668

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1, chloroplastic (EC:1.14.13.81)
Short name:
Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1
Alternative name(s):
Copper response defect 1 protein
Copper-response target 1 protein
Gene namesi
Name:CRD1
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000599? – 407Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1, chloroplastic
Transit peptidei1 – ?ChloroplastSequence analysis

Expressioni

Inductioni

Induced in absence of copper and oxygen. Regulated by CRR1 protein, which activates its transcription in absence of copper.3 Publications

Structurei

3D structure databases

ProteinModelPortaliQ9LD46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AcsF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IFW2 Eukaryota
ENOG410XPVQ LUCA
KOiK04035
OMAiFATHTLT

Family and domain databases

CDDicd01047 ACSF, 1 hit
HAMAPiMF_01840 AcsF, 1 hit
InterProiView protein in InterPro
IPR008434 AcsF
IPR009078 Ferritin-like_SF
IPR003251 Rubrerythrin
PANTHERiPTHR31053 PTHR31053, 1 hit
PfamiView protein in Pfam
PF02915 Rubrerythrin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
TIGRFAMsiTIGR02029 AcsF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LD46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTTLKQQRA SGRVSARQPF RSAAVARPRR STVRVQASAA PLNDGLGFET
60 70 80 90 100
MRDGIKVAAK ETLLTPRFYT TDFDEMEQLF SKEINPNLDM EELNACLNEF
110 120 130 140 150
RNDYNKVHFV RNETFKAAAD KVTGETRRIF IEFLERSCTA EFSGFLLYKE
160 170 180 190 200
LARRMKASSP EVAEMFLLMS RDEARHAGFL NKALSDFNLA LDLGFLTKNR
210 220 230 240 250
TYTYFKPKFI IYATFLSEKI GYWRYITIYR HLQRNPDNQF YPLFEYFENW
260 270 280 290 300
CQDENRHGDF LAACLKAKPE LLNTFEAKLW SKFFCLSVYI TMYLNDHQRT
310 320 330 340 350
KFYESLGLNT RQFNQHVIIE TNRATERLFP VVPDVEDPRF FEILNKMVDV
360 370 380 390 400
NAKLVELSAS SSPLAGLQKL PLLERMASYC LQLLFFKEKD VGSVDIAGSG

ASRNLAY
Length:407
Mass (Da):47,212
Last modified:October 1, 2000 - v1
Checksum:iFD13EE5AC9C55CFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226628 Genomic DNA Translation: AAF65221.1
AF237671 mRNA Translation: AAF63477.1
RefSeqiXP_001692557.1, XM_001692505.1
UniGeneiCre.5891

Genome annotation databases

EnsemblPlantsiEDP04035; EDP04035; CHLREDRAFT_183476
GeneIDi5718021
GrameneiEDP04035; EDP04035; CHLREDRAFT_183476
KEGGicre:CHLREDRAFT_183476

Similar proteinsi

Entry informationi

Entry nameiCRD1_CHLRE
AccessioniPrimary (citable) accession number: Q9LD46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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