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Entry version 57 (11 Dec 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Alpha-agarase

Gene

agaA

Organism
Alteromonas agarilytica
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-agarase. Does not hydrolyze agarotetraose, agarohexaose, kappa-carrageenan, iota-carrageenan or lambda-carrageenan.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.2. Active between pH 6.0 and 9.0.1 Publication

Temperature dependencei

Inactive above 60 degrees Celsius.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-16655

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.158 8321

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM6 Carbohydrate-Binding Module Family 6
GH96 Glycoside Hydrolase Family 96

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-agaraseImported (EC:3.2.1.158)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:agaAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAlteromonas agarilytica
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri105692 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500005596927 – 1429Alpha-agarase1 PublicationAdd BLAST1403

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9LAP7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 161CBM6 1PROSITE-ProRule annotationAdd BLAST133
Domaini211 – 345CBM6 2PROSITE-ProRule annotationAdd BLAST135
Domaini490 – 638PA14PROSITE-ProRule annotationAdd BLAST149
Domaini662 – 793CBM6 3PROSITE-ProRule annotationAdd BLAST132

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 96 family.Sequence analysis

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K20851

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006584 Cellulose-bd_IV
IPR029070 Chitinase_insertion_sf
IPR005084 CMB_fam6
IPR008979 Galactose-bd-like_sf
IPR037524 PA14/GLEYA
IPR003367 Thrombospondin_3-like_rpt
IPR028974 TSP_type-3_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03422 CBM_6, 3 hits
PF02412 TSP_3, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00606 CBD_IV, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103647 SSF103647, 3 hits
SSF49785 SSF49785, 3 hits
SSF54556 SSF54556, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51175 CBM6, 3 hits
PS51820 PA14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LAP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKTKRSLLN SSIAISFAVL GVQAQAETLE LQAESFANSG GTYSDGQPNP
60 70 80 90 100
VTIYNVNGQG AINFVNAGDY VDYNINALGG EYDIEYFVGT GVTSGPNIEV
110 120 130 140 150
LVDVNGTWQS QGSVAVPYGS WDDFQSLTPS HTVTLPVGTS TVRLLAVGST
160 170 180 190 200
WQWNLESFRL TQVSPVEPVG DADNDGVNDN QDLCPNSPSG VTVDNNGCQI
210 220 230 240 250
TGGTDPGGES FVIQMEAFDS TGSDDSRAKG VIIGERGYPQ DKHTVVDSVQ
260 270 280 290 300
TTDWVDYSIN FPSSANYSVS MLASGQTDHA TAVLYLDGTE INEVPVHTGS
310 320 330 340 350
QADFANFQLA GSVYIASGTH TIRVQAQSST GEFSWLWFGD ALTFTNLDSD
360 370 380 390 400
GGNGGEATQD ADNDGVLDSS DSCPNTPTGE PADVTGCSAS QLDDDNDGVS
410 420 430 440 450
NNVDQCPNTV AGTEVDADGC EVIFADADND GIEDSQDFCP NTPAGEAVNN
460 470 480 490 500
SGCGASQLDA DNDGVTNNID QCPNTPAGTQ VDASGCETDN GGEPGDSYYH
510 520 530 540 550
NGQGLLFGRV DGATNFLGEE GYVANPDNYD VTTDLLETDD AIRANSTEVF
560 570 580 590 600
RGEIYDADGH IAFYEHIDDS VRLYIDGQLV LSNDSWENSS QTTDLNLTPG
610 620 630 640 650
WHNFELRLGN ADGGSGAVSG IGFGIDVDGG TNFVHPSNLS PSMFRASGQV
660 670 680 690 700
VVDPILPPSG GIYIQLEDFD ETGTVGRVAS DPNDGFVKGD SNVGWVTNGD
710 720 730 740 750
WGKYHNVFLE AGTYRAFITV STPAGGSYGA RVDIDGEPFA WGYFDSTGGW
760 770 780 790 800
DIAAEYELYG GHLVVESTGN HTLHVEAVGG SDWQWSGDLV RLAKVSDSAV
810 820 830 840 850
KQPRVYNPNE HIVAEIQGPA TGLQYLKTPV EIPLANKVLK SDVWYTYPQN
860 870 880 890 900
RNLVVDGDTP YADFGATGAF WGHPPEHDFY DDTVIMDWAV NVVDDFQSEG
910 920 930 940 950
FEYTARGEFD WGYGWFTEFT TNPQPHYVQT LDGRNVRMTF MGYLSHDGYN
960 970 980 990 1000
NNWLSNHSPA FVPFMKSQVD QILKANPDKL MFDTQTNSTR STDMRTFGGD
1010 1020 1030 1040 1050
FSPYAMENFR VWLLKKYSNA QLVSMGINDI TSFDYGAYLR AQGITHTDWS
1060 1070 1080 1090 1100
NAGDTISGNI PMMEDFIYFN RDVWNQKFAE VLEYIRQQRP NIEIGASTHL
1110 1120 1130 1140 1150
FESRGYIFNE NITFLSGELN LGARTSISEL PTNILVHLKG AQAVDKTLAY
1160 1170 1180 1190 1200
FPYPWEFDEL RIQNAPRFGR GWVAQAYAYG GLFSIPANVW VGGEVFTWSP
1210 1220 1230 1240 1250
GADNYRDIYQ FVRAQANLLD GYTSYAKAGY VHAMFSSMKA GFIDGGNQVQ
1260 1270 1280 1290 1300
SSVKILTEDN INFDMLVFGD AGYPVVPRQA DFDKFEYIFY DGDLNYLTAE
1310 1320 1330 1340 1350
QQAVLDAQGS KVKHIGQRGT IAGLQINVSI NGSVSNETVS AVSRIHETDS
1360 1370 1380 1390 1400
TAPYVVHLIN RPFAGGVTPI LNNVEVAIPA SYFPQGVTSA KLHLPDGSSS
1410 1420
TVAVSTNANG DTVVSVSNLE VWGILELAH
Length:1,429
Mass (Da):154,671
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2ADD331171CBB5DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42 – 43TY → FF AA sequence (PubMed:17513582).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF121273 Genomic DNA Translation: AAF26838.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAF26838

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121273 Genomic DNA Translation: AAF26838.1

3D structure databases

SMRiQ9LAP7
ModBaseiSearch...

Protein family/group databases

CAZyiCBM6 Carbohydrate-Binding Module Family 6
GH96 Glycoside Hydrolase Family 96

Genome annotation databases

KEGGiag:AAF26838

Phylogenomic databases

KOiK20851

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16655
BRENDAi3.2.1.158 8321

Family and domain databases

Gene3Di2.60.120.260, 3 hits
InterProiView protein in InterPro
IPR006584 Cellulose-bd_IV
IPR029070 Chitinase_insertion_sf
IPR005084 CMB_fam6
IPR008979 Galactose-bd-like_sf
IPR037524 PA14/GLEYA
IPR003367 Thrombospondin_3-like_rpt
IPR028974 TSP_type-3_rpt
PfamiView protein in Pfam
PF03422 CBM_6, 3 hits
PF02412 TSP_3, 5 hits
SMARTiView protein in SMART
SM00606 CBD_IV, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49785 SSF49785, 3 hits
SSF54556 SSF54556, 1 hit
PROSITEiView protein in PROSITE
PS51175 CBM6, 3 hits
PS51820 PA14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAGAR_ALTAG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LAP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 1, 2000
Last modified: December 11, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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