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Protein

Malate dehydrogenase

Gene

mdh

Organism
Vibrio mimicus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27NADBy similarity1
Binding sitei74SubstratePROSITE-ProRule annotation1
Binding sitei80SubstratePROSITE-ProRule annotation1
Binding sitei87NADBy similarity1
Binding sitei112SubstratePROSITE-ProRule annotation1
Binding sitei146SubstratePROSITE-ProRule annotation1
Active sitei170Proton acceptorBy similarity1
Binding sitei220NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1 – 6NADBy similarity6
Nucleotide bindingi110 – 112NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiVibrio mimicus
Taxonomic identifieri674 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000113331‹1 – ›222Malate dehydrogenaseAdd BLAST›222

Proteomic databases

PRIDEiQ9L8F6

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9L8F6
SMRiQ9L8F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

eggNOGiCOG0039 LUCA

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11540:SF22 PTHR11540:SF22, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9L8F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AAGGIGQALA LLLKNRLPAG SDLALYDIAP VTPGVAADLS HIPTPVTIKG
60 70 80 90 100
YAGEDPTPAL EGADVVLVSA GVARKPGMDR ADLFNVNAGI VKALAETIAV
110 120 130 140 150
VCPKACVGII TNPVNTTVPI AAEVLKKAGV YDKRKLFGVT TLDVIRSETF
160 170 180 190 200
VAALKDKDPG QVRVPVIGGH SGVTILPLLS QVEGVTFTDE EVAALTKRIQ
210 220
NAGTEVVEAK AGGGSATFSM GQ
Length:222
Mass (Da):22,601
Last modified:October 1, 2000 - v1
Checksum:i593BDCAFBEAE464A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti211A → R in AAK15060 (PubMed:10986258).Curated1
Sequence conflicti211A → R in AAK15061 (PubMed:10986258).Curated1
Sequence conflicti211A → R in AAK15062 (PubMed:10986258).Curated1
Sequence conflicti218F → L in AAK15060 (PubMed:10986258).Curated1
Sequence conflicti218F → L in AAK15061 (PubMed:10986258).Curated1
Sequence conflicti218F → L in AAK15062 (PubMed:10986258).Curated1
Non-terminal residuei2221

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti194A → V in strain: 523-80. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207856 Genomic DNA Translation: AAF40141.1
AF238335 Genomic DNA Translation: AAK15060.1
AF238336 Genomic DNA Translation: AAK15061.1
AF238337 Genomic DNA Translation: AAK15062.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207856 Genomic DNA Translation: AAF40141.1
AF238335 Genomic DNA Translation: AAK15060.1
AF238336 Genomic DNA Translation: AAK15061.1
AF238337 Genomic DNA Translation: AAK15062.1

3D structure databases

ProteinModelPortaliQ9L8F6
SMRiQ9L8F6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9L8F6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG0039 LUCA

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11540:SF22 PTHR11540:SF22, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_VIBMI
AccessioniPrimary (citable) accession number: Q9L8F6
Secondary accession number(s): Q99PX6, Q9AIU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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