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Entry version 116 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Beta-lactamase

Gene

blaCTX-M-9a

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:blaCTX-M-9aImported
Synonyms:blaCTX-M-9Imported, blaCTX-M-9bImported
ORF Names:EOL26_26775Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pMSP071Imported
Plasmid pOZ173Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000283020 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB07808 (1S,2R)-2-[(2,5-difluorophenyl)carbamoyl]cyclopropanecarboxylic acid
DB07823 (2S)-2-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]propanoic acid
DB07055 2-[2-(1H-tetrazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione
DB07865 3-(1H-tetrazol-5-ylamino)cyclohex-2-en-1-one
DB06889 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
DB07729 3-fluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzamide
DB08551 3-{(R)-(Dihydroxyboryl)[(2-thienylacetyl)amino]methyl}benzoic acid
DB07824 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one
DB02841 [(2-Ethoxy-1-Naphthoyl)Amino]Methylboronic Acid
DB02772 Sucrose

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509980229 – 291Beta-lactamaseSequence analysisAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29Pyrrolidone carboxylic acidCombined sources1

Keywords - PTMi

Pyrrolidone carboxylic acidCombined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YLJX-ray0.98A29-291[»]
1YM1X-ray1.12A/B29-291[»]
1YMSX-ray1.60A/B29-291[»]
1YMXX-ray1.70A/B29-291[»]
2P74X-ray0.88A/B29-291[»]
3G2YX-ray1.31A/B29-291[»]
3G2ZX-ray1.50A/B29-291[»]
3G30X-ray1.80A29-291[»]
3G31X-ray1.70A/B29-291[»]
3G32X-ray1.31A/B29-291[»]
3G34X-ray1.31A/B29-291[»]
3G35X-ray1.41A/B29-291[»]
3HLWX-ray1.50A/B29-291[»]
3HREX-ray1.45A/B29-291[»]
3HUOX-ray1.50A/B29-291[»]
3HVFX-ray1.50A/B29-291[»]
3Q07X-ray1.50A/B29-291[»]
3Q1FX-ray1.50A/B29-291[»]
4DDSX-ray1.36A/B29-291[»]
4DDYX-ray1.36A/B29-291[»]
4DE0X-ray1.12A/B29-291[»]
4DE1X-ray1.26A/B29-291[»]
4DE2X-ray1.40A/B29-291[»]
4DE3X-ray1.44A/B29-291[»]
4LENX-ray1.50A/B29-291[»]
5KMTX-ray1.70A/B2-2[»]
A/B4-291[»]
5KMUX-ray1.80A2-2[»]
A4-291[»]
5UJOX-ray1.35A/B29-291[»]

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K18767

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00118 BLACTAMASEA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56601 SSF56601, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9L5C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTKRVQRMM FAAAACIPLL LGSAPLYAQT SAVQQKLAAL EKSSGGRLGV
60 70 80 90 100
ALIDTADNTQ VLYRGDERFP MCSTSKVMAA AAVLKQSETQ KQLLNQPVEI
110 120 130 140 150
KPADLVNYNP IAEKHVNGTM TLAELSAAAL QYSDNTAMNK LIAQLGGPGG
160 170 180 190 200
VTAFARAIGD ETFRLDRTEP TLNTAIPGDP RDTTTPRAMA QTLRQLTLGH
210 220 230 240 250
ALGETQRAQL VTWLKGNTTG AASIRAGLPT SWTAGDKTGS GDYGTTNDIA
260 270 280 290
VIWPQGRAPL VLVTYFTQPQ QNAESRRDVL ASAARIIAEG L
Length:291
Mass (Da):30,951
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8CB0A7739B9469E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF174129 Genomic DNA Translation: AAF05311.2
AF252621 Genomic DNA Translation: AAF72529.1
EU418915 Genomic DNA Translation: ACM04461.1
HM569735 Genomic DNA Translation: ADJ19345.1
AJ416345 Genomic DNA Translation: CAC95176.1
AM040708 Genomic DNA Translation: CAJ13580.1
RZVV01000280 Genomic DNA Translation: RVR37685.1

NCBI Reference Sequences

More...
RefSeqi
WP_032489926.1, NZ_RZVV01000280.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAF05311

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174129 Genomic DNA Translation: AAF05311.2
AF252621 Genomic DNA Translation: AAF72529.1
EU418915 Genomic DNA Translation: ACM04461.1
HM569735 Genomic DNA Translation: ADJ19345.1
AJ416345 Genomic DNA Translation: CAC95176.1
AM040708 Genomic DNA Translation: CAJ13580.1
RZVV01000280 Genomic DNA Translation: RVR37685.1
RefSeqiWP_032489926.1, NZ_RZVV01000280.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YLJX-ray0.98A29-291[»]
1YM1X-ray1.12A/B29-291[»]
1YMSX-ray1.60A/B29-291[»]
1YMXX-ray1.70A/B29-291[»]
2P74X-ray0.88A/B29-291[»]
3G2YX-ray1.31A/B29-291[»]
3G2ZX-ray1.50A/B29-291[»]
3G30X-ray1.80A29-291[»]
3G31X-ray1.70A/B29-291[»]
3G32X-ray1.31A/B29-291[»]
3G34X-ray1.31A/B29-291[»]
3G35X-ray1.41A/B29-291[»]
3HLWX-ray1.50A/B29-291[»]
3HREX-ray1.45A/B29-291[»]
3HUOX-ray1.50A/B29-291[»]
3HVFX-ray1.50A/B29-291[»]
3Q07X-ray1.50A/B29-291[»]
3Q1FX-ray1.50A/B29-291[»]
4DDSX-ray1.36A/B29-291[»]
4DDYX-ray1.36A/B29-291[»]
4DE0X-ray1.12A/B29-291[»]
4DE1X-ray1.26A/B29-291[»]
4DE2X-ray1.40A/B29-291[»]
4DE3X-ray1.44A/B29-291[»]
4LENX-ray1.50A/B29-291[»]
5KMTX-ray1.70A/B2-2[»]
A/B4-291[»]
5KMUX-ray1.80A2-2[»]
A4-291[»]
5UJOX-ray1.35A/B29-291[»]
ModBaseiSearch...
MobiDBiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Chemistry databases

DrugBankiDB07808 (1S,2R)-2-[(2,5-difluorophenyl)carbamoyl]cyclopropanecarboxylic acid
DB07823 (2S)-2-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]propanoic acid
DB07055 2-[2-(1H-tetrazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione
DB07865 3-(1H-tetrazol-5-ylamino)cyclohex-2-en-1-one
DB06889 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
DB07729 3-fluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzamide
DB08551 3-{(R)-(Dihydroxyboryl)[(2-thienylacetyl)amino]methyl}benzoic acid
DB07824 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one
DB02841 [(2-Ethoxy-1-Naphthoyl)Amino]Methylboronic Acid
DB02772 Sucrose

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAF05311

Phylogenomic databases

KOiK18767

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9L5C8_ECOLX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9L5C8
Secondary accession number(s): Q9RP34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, PlasmidImported
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