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Entry version 105 (17 Jun 2020)
Sequence version 1 (01 Oct 2000)
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Protein

FO synthase

Gene

fbiC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters. The clusters are coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme F0 biosynthesis

This protein is involved in the pathway coenzyme F0 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F0 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi89Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi93Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi96Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi548Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi552Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi555Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Transferase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00072

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FO synthase
Including the following 2 domains:
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC:4.3.1.32)
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase (EC:2.5.1.147)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fbiC
Ordered Locus Names:SCO4429
ORF Names:SCD6.07
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri100226 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001973 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001477751 – 867FO synthaseAdd BLAST867

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9KZZ7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
100226.SCO4429

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 325Radical SAM core 1PROSITE-ProRule annotationAdd BLAST251
Domaini534 – 769Radical SAM core 2PROSITE-ProRule annotationAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 407CofG-likeAdd BLAST332
Regioni511 – 844CofH-likeAdd BLAST334

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the radical SAM superfamily. CofG family.Curated
In the C-terminal section; belongs to the radical SAM superfamily. CofH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DKF Bacteria
COG1060 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010522_1_0_11

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9KZZ7

KEGG Orthology (KO)

More...
KOi
K11779

Identification of Orthologs from Complete Genome Data

More...
OMAi
PWPQIDE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9KZZ7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_01611 FO_synth_sub1, 1 hit
MF_01612 FO_synth_sub2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR019939 CofG_family
IPR019940 CofH_family
IPR006638 Elp3/MiaB/NifB
IPR034405 F420
IPR020050 FO_synthase_su2
IPR007197 rSAM

The PANTHER Classification System

More...
PANTHERi
PTHR43076 PTHR43076, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04055 Radical_SAM, 2 hits

Structure-Function Linkage Database

More...
SFLDi
SFLDF00293 ((2_3_4_5-tetrahydroxypentyl)a, 1 hit
SFLDF00294 7_8-didemethyl-8-hydroxy-5-dea, 1 hit
SFLDS00029 Radical_SAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00729 Elp3, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03550 F420_cofG, 1 hit
TIGR03551 F420_cofH, 1 hit
TIGR00423 TIGR00423, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51918 RADICAL_SAM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9KZZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTSATSGTG PADPAGPTEN SMRRALKRAR DGVALDASEA AVLLQARGAH
60 70 80 90 100
LDALTASAAR VRDAGLEAAG RPGVITYSKS VFVPLTRLCR DKCHYCTFVT
110 120 130 140 150
VPGKLRRAGH GMFMSPDEVL DIARKGAALG CKEALITLGD KPEDRWPEAR
160 170 180 190 200
EWLDAHGYDD TIAYVRAVSI RILEETGLLP HLNPGVMTWT DFQRLKPVAP
210 220 230 240 250
SMGMMLETTA TRLWSEPGGP HHGSPDKEPA VRLRVLEDAG RSSVPFTSGI
260 270 280 290 300
LIGIGETYEE RAESLFALRR VSRSYHGIQE LIIQNFRAKP DTAMRGMPDA
310 320 330 340 350
ELDELVAAVA VARHIMGPSA CLQAPPNLVD AEYERLIGAG IDDWGGVSPL
360 370 380 390 400
TIDHVNPERP WPQIDELAAT SRAAGFELRE RLCVYPEFVR RGEPWLDPRL
410 420 430 440 450
RPHVAALADP ETGLAREDAV VEGHAWQEPD EAFTATGRTD LHATIDTEGR
460 470 480 490 500
TSDRRDDFDE VYGDWGALRE AAAPGMAPER IDTDVRAALA TAADDPTKLT
510 520 530 540 550
DDEALALLHA EGPALDALCG IADDVRRSVV GDDVTYIVTR NINFTNVCYT
560 570 580 590 600
GCRFCAFAQR RTDADAYTLS LDQVADRAQQ AWEVGAVEVC MQGGIHPDLP
610 620 630 640 650
GTAYFDIARA VKERVPGMHV HAFSPMEVVN GATRTGLSIR EWLTAAKEAG
660 670 680 690 700
LDSVPGTAAE ILDDEVRWIL TKGKLPAATW IEVIETAHEL GIRSSSTMMY
710 720 730 740 750
GHVDQPRHWL GHLRTLAGIQ RRTGGFTEFV TLPFIHTNAP VYLAGIARPG
760 770 780 790 800
PTLRDNRAVT AMARLLLHPH IPNIQTSWVK LGTEGAAEML RSGANDLGGT
810 820 830 840 850
LMEETISRMA GSSYGSYKSV KDLIAVADAA GRPAKPRTTL YGPVPEERQR
860
AARDSDGHLP ELLPVLD
Length:867
Mass (Da):94,177
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i586E9311B9F7377D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL939120 Genomic DNA Translation: CAB88436.1

NCBI Reference Sequences

More...
RefSeqi
NP_628596.1, NC_003888.3
WP_011029648.1, NZ_VNID01000017.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB88436; CAB88436; CAB88436

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1099869

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sco:SCO4429

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|100226.15.peg.4498

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA Translation: CAB88436.1
RefSeqiNP_628596.1, NC_003888.3
WP_011029648.1, NZ_VNID01000017.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi100226.SCO4429

Proteomic databases

PRIDEiQ9KZZ7

Genome annotation databases

EnsemblBacteriaiCAB88436; CAB88436; CAB88436
GeneIDi1099869
KEGGisco:SCO4429
PATRICifig|100226.15.peg.4498

Phylogenomic databases

eggNOGiENOG4105DKF Bacteria
COG1060 LUCA
HOGENOMiCLU_010522_1_0_11
InParanoidiQ9KZZ7
KOiK11779
OMAiPWPQIDE
PhylomeDBiQ9KZZ7

Enzyme and pathway databases

UniPathwayiUPA00072

Family and domain databases

Gene3Di3.20.20.70, 2 hits
HAMAPiMF_01611 FO_synth_sub1, 1 hit
MF_01612 FO_synth_sub2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR019939 CofG_family
IPR019940 CofH_family
IPR006638 Elp3/MiaB/NifB
IPR034405 F420
IPR020050 FO_synthase_su2
IPR007197 rSAM
PANTHERiPTHR43076 PTHR43076, 1 hit
PfamiView protein in Pfam
PF04055 Radical_SAM, 2 hits
SFLDiSFLDF00293 ((2_3_4_5-tetrahydroxypentyl)a, 1 hit
SFLDF00294 7_8-didemethyl-8-hydroxy-5-dea, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR03550 F420_cofG, 1 hit
TIGR03551 F420_cofH, 1 hit
TIGR00423 TIGR00423, 1 hit
PROSITEiView protein in PROSITE
PS51918 RADICAL_SAM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBIC_STRCO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9KZZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: June 17, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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