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Entry version 81 (02 Jun 2021)
Sequence version 2 (01 Oct 2001)
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Protein

Probable cell-surface antigen I/II

Gene

pas

Organism
Streptococcus intermedius
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cell-surface antigen I/II
Alternative name(s):
PAa1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus intermedius
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1338 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcusStreptococcus anginosus group

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell wall, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037912139 – 1280Probable cell-surface antigen I/IIAdd BLAST1242
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00003791221281 – 1310Removed by sortasePROSITE-ProRule annotationAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1280Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9KW51

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9KW51

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati146 – 220Ag I/II A 1PROSITE-ProRule annotationAdd BLAST75
Repeati221 – 302Ag I/II A 2PROSITE-ProRule annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 90DisorderedSequence analysisAdd BLAST51
Regioni297 – 668V-region (lectin-like)By similarityAdd BLAST372
Regioni330 – 349DisorderedSequence analysisAdd BLAST20
Regioni663 – 736DisorderedSequence analysisAdd BLAST74

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1277 – 1281LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 85Polar residuesSequence analysisAdd BLAST46
Compositional biasi695 – 736Pro residuesSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the antigen I/II family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.530.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR021197, Cross-wall-target_lipo_motif
IPR013574, Glucan-bd_C/Surface_Ag-I/II_V
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor
IPR036234, SA_I/II_PAC_V_sf
IPR009578, Surface_Ag_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 1 hit
PF16364, Antigen_C, 1 hit
PF08363, GbpC, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF06696, Strep_SA_rep, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74914, SSF74914, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04228, isopep_sspB_C2, 1 hit
TIGR03726, strep_RK_lipo, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51965, AG_I_II_AR, 2 hits
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9KW51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKRKEVFGF RKSKVAKTLC GAVLGAALLA MVDQQVAAEE TTKSNSTTNV
60 70 80 90 100
AVTATGNPAT NLPEAQGSAS KEAEQSQNQA GETNGSIPVE VPKTDLDQAA
110 120 130 140 150
KEAKSAGVNV VQDADVNKGT VKTAGEAAQK ETEIKEDYTK QAEDIKKTTD
160 170 180 190 200
QYKSDVAAHE AEVAKIKAKN QATKEQYEKD MAAHKAEVER INAANAASKA
210 220 230 240 250
AYETKLAQYQ AELKRVQEAN ATNEANYQAK LTAYKTELAR VQKANADAKA
260 270 280 290 300
AYEAAVAANN AANAALTAEN TAIKKRNADA KADYEAKLAK YQADLAKYQK
310 320 330 340 350
DLAEYPQKLK EYNEEQAKIK EALKKLEQDK NKDGHLTEPS AQSLVYDSEP
360 370 380 390 400
DAKLSLTTED GTLLKSSVVD EAFSKSTSKA KYDQKILQLD DLDIRGLEKA
410 420 430 440 450
DSATSTVELY GNIGNKSTWT TNVGNNTEVK WGSVLLKRGQ SVTATYTNLQ
460 470 480 490 500
KTYYNGKKVS KIVYKYTVDK DSKFQNPSGN VWLGVFSDPT LGVFASAYTG
510 520 530 540 550
QVEKDTSIFI KNEFTFYDEN DQPINFDNAL LSVASLNREN NSIEMAKDYT
560 570 580 590 600
GKFVRISGSS IDEKDGKIYA TKTLNFKKGQ GGSRWTMYPN GQEGSGWDSS
610 620 630 640 650
DAPNSWYGAG AVKISGQHNS ITLGAISATL VVPSDSVMAV ETGKKPNIWY
660 670 680 690 700
SLNGKIRAVN VPKITKENPT PPVEPTAPQA PTYEVEKPLN PAPVAPNYEK
710 720 730 740 750
EPTPPTPTPD QPEPNKPVEP TYEAIPTPPT DPVYQNLPTP PAVPTVHFRY
760 770 780 790 800
YKLAVQPQVN KEIKNNNDVD IDKTLVAKQS VVKFQLKTAD LPAGRAKTTS
810 820 830 840 850
FVLVDPLPSG YQFNLEATKA ASPGFDVSYD KATNTVTFKA TAATLATFNA
860 870 880 890 900
DLTKSVATIY PTVVGQVLND GATYKNNFTL TVNDAYGIKS NVVRVTTPGK
910 920 930 940 950
PNDPDNPNNN YIKPTKVNKN ENGVVIDGKT VLAGSTNYYE LTWDLDQYKN
960 970 980 990 1000
DRSSADTIQK GFYYVDDYPE EALELRQDLV KITDANGNKV TGVSVDHYTS
1010 1020 1030 1040 1050
LEAAPQEVRD VLSKAGIRPK GAFQIFRADN PREFYDTYVK NGIDLKIVSP
1060 1070 1080 1090 1100
MVVKKQMGQT GGSYENQAYQ IDFGNGYASN IVINNVPKIN PKKDVTLTLD
1110 1120 1130 1140 1150
PADTNNVDGQ TIPLNTVFNY RLIGGIIPAD HSEELFEYNF YDDYDQTGDR
1160 1170 1180 1190 1200
YTGQYKVFAK VDITLKDGSV IKSGTDLTQH TTAEVDATKG ALTIKFKEDF
1210 1220 1230 1240 1250
LRSVSIDSAF QAESYIQMKR IAAGTFENTY VNTVNKVAYA SNTVRTTTPQ
1260 1270 1280 1290 1300
APRSEVPKRP TPVSYLTNKL SSAPATLPQT GTTDSSYMPY LGVIALLSVL
1310
GLGQLKRNEK
Length:1,310
Mass (Da):143,090
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0021781F5D4DB793
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB045140 Genomic DNA Translation: BAA96878.2

Protein sequence database of the Protein Information Resource

More...
PIRi
C60339

NCBI Reference Sequences

More...
RefSeqi
WP_003075937.1, NZ_LS483436.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57845466

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045140 Genomic DNA Translation: BAA96878.2
PIRiC60339
RefSeqiWP_003075937.1, NZ_LS483436.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6E36X-ray1.70A/B282-682[»]
6E3FX-ray2.70A747-1241[»]
SMRiQ9KW51
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiQ9KW51

Genome annotation databases

GeneIDi57845466

Family and domain databases

Gene3Di2.60.530.10, 1 hit
InterProiView protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR021197, Cross-wall-target_lipo_motif
IPR013574, Glucan-bd_C/Surface_Ag-I/II_V
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor
IPR036234, SA_I/II_PAC_V_sf
IPR009578, Surface_Ag_rpt
PfamiView protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 1 hit
PF16364, Antigen_C, 1 hit
PF08363, GbpC, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF06696, Strep_SA_rep, 3 hits
SUPFAMiSSF74914, SSF74914, 1 hit
TIGRFAMsiTIGR04228, isopep_sspB_C2, 1 hit
TIGR03726, strep_RK_lipo, 1 hit
PROSITEiView protein in PROSITE
PS51965, AG_I_II_AR, 2 hits
PS50847, GRAM_POS_ANCHORING, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAS_STRIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9KW51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 1, 2001
Last modified: June 2, 2021
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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