The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q9KVK6 (CDGJ_VIBCH)
Protein
Cyclic di-GMP phosphodiesterase CdgJ
Gene
cdgJ
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Functioni
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Positively regulates motility and negatively regulates biofilm formation.
1 PublicationCatalytic activityi
- EC:3.1.4.521 Publication
GO - Molecular functioni
- cyclic-guanylate-specific phosphodiesterase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase |
Ligand | c-di-GMP |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cdgJ1 Publication Ordered Locus Names:VC_0137Imported |
Organismi | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
Taxonomic identifieri | 243277 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion mutant exhibits decreased motility. Mutation causes a slight decrease in flaA expression but does not affect flagellar morphology. Mutant has enhanced biofilm formation and vps gene expression.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 46 – 48 | ELL → AAA: Lack of activity. 1 Publication | 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000439658 | 1 – 432 | Cyclic di-GMP phosphodiesterase CdgJAdd BLAST | 432 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 232 | EALPROSITE-ProRule annotationAdd BLAST | 232 | |
Domaini | 226 – 413 | HDODPROSITE-ProRule annotationAdd BLAST | 188 |
Phylogenomic databases
eggNOGi | COG3434, Bacteria |
HOGENOMi | CLU_044951_2_0_6 |
OMAi | RQPIFNR |
Family and domain databases
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR014408, dGMP_Pdiesterase_EAL/HD-GYP IPR001633, EAL_dom IPR035919, EAL_sf IPR013976, HDOD |
Pfami | View protein in Pfam PF00563, EAL, 1 hit PF08668, HDOD, 1 hit |
PIRSFi | PIRSF003180, DiGMPpdiest_YuxH, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit PS51833, HDOD, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9KVK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRCLWAAEC CWLPPKRKQP FEDTMYTTYV ARQPILNAKR HTLGYELLFR
60 70 80 90 100
DGEKNAFPEY MDADRATYRL IVENFLSLGT NPRIARSRCF INFPHKSLIR
110 120 130 140 150
RLPLTLPREQ IVVEILETCQ PTDDLFEAVQ ELSQRGYLLA LDDFVYSPAW
160 170 180 190 200
ERFLPYVQIV KIDIMAMGLD KACEFVRGRL AQGSRRRFLA ERVETEDEFH
210 220 230 240 250
QARHAGFTFF QGYFFSKPEI IKQRYVSPEH VIAMQLFREV CQPEVDYVRV
260 270 280 290 300
ERLVAQDIAL SYKLLRFVNT MSDRISVSIS SFRQALVYLG QDKLRIFVSL
310 320 330 340 350
AVASYISSKK PKELYNLSLQ RAQFCQLMAT HTHFKAHREQ AFLIGMFSVL
360 370 380 390 400
DALLDTSIEQ LVEQLPLADD VKLALREREG PLGTLLDLEE CFEKADWQGV
410 420 430
EQHCLELGFD LEDVRQELIE AQRWSQDINR LI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003852 Genomic DNA Translation: AAF93314.1 |
PIRi | H82358 |
Genome annotation databases
EnsemblBacteriai | AAF93314; AAF93314; VC_0137 |
KEGGi | vch:VC_0137 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003852 Genomic DNA Translation: AAF93314.1 |
PIRi | H82358 |
3D structure databases
AlphaFoldDBi | Q9KVK6 |
SMRi | Q9KVK6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 243277.VC_0137 |
Protocols and materials databases
DNASUi | 2615266 |
Genome annotation databases
EnsemblBacteriai | AAF93314; AAF93314; VC_0137 |
KEGGi | vch:VC_0137 |
Phylogenomic databases
eggNOGi | COG3434, Bacteria |
HOGENOMi | CLU_044951_2_0_6 |
OMAi | RQPIFNR |
Family and domain databases
Gene3Di | 3.20.20.450, 1 hit |
InterProi | View protein in InterPro IPR014408, dGMP_Pdiesterase_EAL/HD-GYP IPR001633, EAL_dom IPR035919, EAL_sf IPR013976, HDOD |
Pfami | View protein in Pfam PF00563, EAL, 1 hit PF08668, HDOD, 1 hit |
PIRSFi | PIRSF003180, DiGMPpdiest_YuxH, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit PS51833, HDOD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDGJ_VIBCH | |
Accessioni | Q9KVK6Primary (citable) accession number: Q9KVK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2017 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |