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Protein

UvrABC system protein A

Gene

uvrA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8
Zinc fingeri252 – 279C4-typeUniRule annotationAdd BLAST28
Nucleotide bindingi639 – 646ATPUniRule annotation8
Zinc fingeri739 – 765C4-typeUniRule annotationAdd BLAST27

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: UniProtKB-UniRule
  • DNA binding Source: UniProtKB-UniRule
  • excinuclease ABC activity Source: TIGR
  • zinc ion binding Source: UniProtKB-UniRule

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Excision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciVCHO:VC0394-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Ordered Locus Names:VC_0394
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000931111 – 940UvrABC system protein AAdd BLAST940

Proteomic databases

PRIDEiQ9KUW5

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC0394

Structurei

3D structure databases

ProteinModelPortaliQ9KUW5
SMRiQ9KUW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 586ABC transporter 1UniRule annotationAdd BLAST278
Domaini606 – 936ABC transporter 2UniRule annotationAdd BLAST331

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 279C4-typeUniRule annotationAdd BLAST28
Zinc fingeri739 – 765C4-typeUniRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG4105C5U Bacteria
COG0178 LUCA
KOiK03701
OMAiVIEMNFL

Family and domain databases

HAMAPiMF_00205 UvrA, 1 hit
InterProiView protein in InterPro
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR004602 UvrA
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00630 uvra, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9KUW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKIEVRGAR THNLKNINLT IPRDKLIVIT GLSGSGKSSL AFDTLYAEGQ
60 70 80 90 100
RRYVESLSAY ARQFLSLMEK PDVDHIEGLS PAISIEQKST SHNPRSTVGT
110 120 130 140 150
ITEVYDYLRL LYARVGEPRC PEHQVPLKAQ TISQMVDKVL ELPEGSKMML
160 170 180 190 200
LATIVKERKG EHVKTLENLA AQGFIRARID GETCDLTDPP KLELHKKHTI
210 220 230 240 250
EVIVDRFKVR SDLQQRLAES FETALELSGG IVVVAPMEGD GEEQIFSANF
260 270 280 290 300
ACPHCGYSMR ELEPRLFSFN NPAGACPTCD GLGVQQYFDP DRVIQDANLS
310 320 330 340 350
LAQGAIRGWD QKNFYYFQML TALAEHYDFD VHTPFNKLSK KIQEIILHGS
360 370 380 390 400
GRTEIEFKYI NDRGDIRLKK HPFEGILHNL ERRYRDTESN SVREELAKYI
410 420 430 440 450
SNKPCSSCDG TRLKIEARNV FINDTALPTI VELSIADALT FFQELKLEGQ
460 470 480 490 500
RAQIAEKVMK EINDRLQFLV NVGLNYLNLS RSAETLSGGE AQRIRLASQI
510 520 530 540 550
GAGLVGVMYV LDEPSIGLHQ RDNERLLQTL THLRNLGNTV LVVEHDEDAI
560 570 580 590 600
RMADHVIDIG PGAGVHGGMV VAEGNVEEII ANPNSLTGQY LSGVKKIAVP
610 620 630 640 650
EQRTPKDAKK TVELKGAVGN NLKNVDLSIP VGLFTCVTGV SGSGKSTLIN
660 670 680 690 700
DTFFKIAHTA LNGATTATPA PYRSIQGLEH FDKVIDIDQS PIGRTPRSNP
710 720 730 740 750
ATYTGIFTPI RELFAGTQES RSRGYQPGRF SFNVRGGRCE ACQGDGVIKV
760 770 780 790 800
EMHFLPDVYV PCDVCKGKRY NRETLEVRYK GKTIDEVLDM TVEDAREFFD
810 820 830 840 850
PVPVIARKLQ TLMDVGLSYI RLGQSATTLS GGEAQRVKLA RELSKRDTGK
860 870 880 890 900
TLYILDEPTT GLHFHDIQQL LSVLHRLRDH GNTVVVIEHN LDVIKTADWI
910 920 930 940
IDLGPEGGQG GGLIIAEGTP EDVAQIEASH TARFLKPLLN
Length:940
Mass (Da):104,328
Last modified:October 1, 2000 - v1
Checksum:i84F93B9DF686F6F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF93567.1
PIRiA82329
RefSeqiNP_230048.1, NC_002505.1
WP_000357696.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF93567; AAF93567; VC_0394
GeneIDi2614991
KEGGivch:VC0394
PATRICifig|243277.26.peg.369

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF93567.1
PIRiA82329
RefSeqiNP_230048.1, NC_002505.1
WP_000357696.1, NC_002505.1

3D structure databases

ProteinModelPortaliQ9KUW5
SMRiQ9KUW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0394

Proteomic databases

PRIDEiQ9KUW5

Protocols and materials databases

DNASUi2614991
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93567; AAF93567; VC_0394
GeneIDi2614991
KEGGivch:VC0394
PATRICifig|243277.26.peg.369

Phylogenomic databases

eggNOGiENOG4105C5U Bacteria
COG0178 LUCA
KOiK03701
OMAiVIEMNFL

Enzyme and pathway databases

BioCyciVCHO:VC0394-MONOMER

Family and domain databases

HAMAPiMF_00205 UvrA, 1 hit
InterProiView protein in InterPro
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR004602 UvrA
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00630 uvra, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUVRA_VIBCH
AccessioniPrimary (citable) accession number: Q9KUW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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