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Entry version 82 (26 Feb 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Actin cross-linking toxin VgrG1

Gene

vgrG1

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:26150500). Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity (PubMed:26150500). Acts also directly as an actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:17873062, PubMed:20150509). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (By similarity). Acts as an acid--amino-acid ligase that transfers the gamma-phosphoryl group of ATP to the 'Glu-270' actin residue, resulting in the formation of an activated acyl phosphate intermediate. This intermediate is further hydrolyzed and the energy of hydrolysis is utilized for the formation of the amide bond between actin subunits (By similarity).By similarity3 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 Mg2+ ions per subunit. Can also use Mn2+ ions instead of Mg2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi743Magnesium 1; catalytic; for actin cross-linking activityBy similarity1
Metal bindingi743Magnesium 2; catalytic; for actin cross-linking activityBy similarity1
Metal bindingi805Magnesium 2; catalytic; for actin cross-linking activityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei808ATP; via carbonyl oxygenCombined sources1
Metal bindingi889Magnesium 1; catalytic; for actin cross-linking activityBy similarity1
Binding sitei995ATP; via carbonyl oxygenBy similarity1
Metal bindingi1066Magnesium 1; catalytic; for actin cross-linking activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi739 – 743ATPCombined sources5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Toxin
Biological processVirulence
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
VCHO:VC1416-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin cross-linking toxin VgrG1 (EC:6.3.2.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vgrG11 Publication
Synonyms:vgrG-11 Publication
Ordered Locus Names:VC_1416Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243277 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion leads to a loss of TseL secretion and in turn loss of its ability to mediate prey cell killing.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004341201 – 1163Actin cross-linking toxin VgrG1Add BLAST1163

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with protein VC1417.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243277.VC_1416

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9KS45

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini728 – 1163ACDPROSITE-ProRule annotationAdd BLAST436

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi692 – 736Pro-richPROSITE-ProRule annotationAdd BLAST45

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VgrG protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CS6 Bacteria
COG3501 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008414_0_0_6

KEGG Orthology (KO)

More...
KOi
K11904

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032074 ACD_dom
IPR017847 T6SS_RhsGE_Vgr_subset
IPR006533 T6SS_Vgr_RhsGE
IPR037026 Vgr_OB-fold_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16671 ACD, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01646 vgr_GE, 1 hit
TIGR03361 VI_Rhs_Vgr, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51772 ACD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9KS45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLAYSIEV EGLEDETLVV RGFHGQESLS NSVFLGQACY GFRYEVQLAS
60 70 80 90 100
RVSNLTAEQM VDKRAELKLY RNSQLVQRVH GIVRAFSQGD IGHHHTFYQL
110 120 130 140 150
TLVPALERLS LRHNSRIFQK QTVPEILSIL LQEMGINDYA FALKRDGVQR
160 170 180 190 200
EFCVQYRESD IDFLHRLAAE EGLVYSFVHE AGKHTLYFSD ASDSLSKLPE
210 220 230 240 250
PIPYNALVGG AIDTPYIHGL TYRTQAEVSE VQLKDYSFKK PAYSFLQTVQ
260 270 280 290 300
GTELDYQQTR YQHFDAPGRY KDDVNGAAFS QIRLDYLRRH AHTATGQSNE
310 320 330 340 350
PLLRAGYKFD LQEHLDPAMN RDWVVVSINH QGEQPQALQE DGGSGATTYS
360 370 380 390 400
NQFSLIPGHL HWRAEPQPKP QVDGPMIATV VGPEGEEIFC DEHGRVKIHF
410 420 430 440 450
PWDRYSNGNE QSSCWVRVSQ GWAGSQYGFI AIPRIGHEVI VEFLNGDPDQ
460 470 480 490 500
PIITGRTYHA TNTPPYTLPE HKTKTVLRTE THQGEGFNEL SFEDQAGKEQ
510 520 530 540 550
IYLHAQKDFD GLIENDHTTV IRHDHHLTVE NDQFTQIKHN QHLTVEWESR
560 570 580 590 600
EAVTGEQVLS IEGSLHVKTG KVWVNEAGTE IHVKAGQKVV IEAGSEITVK
610 620 630 640 650
AGGSFVKVDP AGVHLSGALV NLNSGGSAGS GSGFGGAMPA LPGGLEPAVA
660 670 680 690 700
LAPPQTISYQ ALLQAEQANV PAVKVCPLAA QEATPAVNSI TPPPPPPIAP
710 720 730 740 750
PMAPPQPIMN PQPTANAQPN LGRSTKATPD FPTHFPKSSI GIENELAGLV
760 770 780 790 800
VAMPANSAQK FGYVKSAQGD ALFMLTKDMN QGSYQRPPSL QDGKNYQNWQ
810 820 830 840 850
THTVELVSYP CEMDDKAAVE TRKQAMLWLA THFTTHIDQS NHQPLAPIQS
860 870 880 890 900
EDGRFVIEIT NAKHVIAAGN GISAESQGQT ITMTPSGQQA TVGVAAKGFG
910 920 930 940 950
TSATPELRLL ESAPWYQKSL KSQFASLTSA ENLDDKELAA NVFAYLTSIY
960 970 980 990 1000
LKTAELAKKF GIYINEWDPM SEQITPNANG LTDPKVKNAW EILPRTKPSK
1010 1020 1030 1040 1050
IVEILSKSDA KAVMKHIKPQ LQSRYSESLS KNVFQYFQDG GEVAGHGINN
1060 1070 1080 1090 1100
ATVGDKHSPE LAILFEFRTV PNELQSYLPK TESTTKSEVK LLDQFDPMKR
1110 1120 1130 1140 1150
KTVIQQVESL VQNSGDAFDK WYQSYRDSMN QPPVKNAKKI ASANQKAQWV
1160
KEHNPQEWQR IIA
Length:1,163
Mass (Da):128,829
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF95DFEC31FE9F15
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF94573.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D82202

NCBI Reference Sequences

More...
RefSeqi
NP_231059.1, NC_002505.1
WP_000212116.1, NZ_LT906614.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAF94573; AAF94573; VC_1416

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2614048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vch:VC1416

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|243277.26.peg.1345

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF94573.1
PIRiD82202
RefSeqiNP_231059.1, NC_002505.1
WP_000212116.1, NZ_LT906614.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GQKX-ray2.36A717-1111[»]
SMRiQ9KS45
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi243277.VC_1416

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2614048

Genome annotation databases

EnsemblBacteriaiAAF94573; AAF94573; VC_1416
GeneIDi2614048
KEGGivch:VC1416
PATRICifig|243277.26.peg.1345

Phylogenomic databases

eggNOGiENOG4105CS6 Bacteria
COG3501 LUCA
HOGENOMiCLU_008414_0_0_6
KOiK11904

Enzyme and pathway databases

BioCyciVCHO:VC1416-MONOMER

Family and domain databases

Gene3Di2.40.50.230, 1 hit
InterProiView protein in InterPro
IPR032074 ACD_dom
IPR017847 T6SS_RhsGE_Vgr_subset
IPR006533 T6SS_Vgr_RhsGE
IPR037026 Vgr_OB-fold_dom_sf
PfamiView protein in Pfam
PF16671 ACD, 1 hit
TIGRFAMsiTIGR01646 vgr_GE, 1 hit
TIGR03361 VI_Rhs_Vgr, 1 hit
PROSITEiView protein in PROSITE
PS51772 ACD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVGRG1_VIBCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9KS45
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: October 1, 2000
Last modified: February 26, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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