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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33GTPUniRule annotation1
Binding sitei61GTPUniRule annotation1
Binding sitei78GTPUniRule annotation1
Metal bindingi108MagnesiumUniRule annotation1
Binding sitei108GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 22GTPUniRule annotation3

GO - Molecular functioni

  • catalytic activity Source: TIGR
  • GTP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • molybdenum cofactor guanylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  • Mo-molybdopterin cofactor biosynthetic process Source: TIGR

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC1526-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:VC_1526
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001349211 – 203Molybdenum cofactor guanylyltransferaseAdd BLAST203

Proteomic databases

PRIDEiQ9KRV8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC1526

Structurei

3D structure databases

ProteinModelPortaliQ9KRV8
SMRiQ9KRV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6R Bacteria
COG0746 LUCA
KOiK03752
OMAiFVPCDVP

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR02665 molyb_mobA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KRV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITTQTLPTL QPSDTSWVIL AGGQASRMGG QDKGLIQLNG QPLVQHVIDK
60 70 80 90 100
LAPQTPTLLI NANRNQSQYQ QFAPVISDEF PDYPGPLGGI HAGLSHAPTD
110 120 130 140 150
WVGFVPCDSP LICDDLVARF CQAVKPESDI LVAHDGEHQQ PVFTLFHKRV
160 170 180 190 200
LPKLSAFLAR GDRKIILLYD ECHTSYVDFS DAPSCFFNLN TPQELAQFGA

LHP
Length:203
Mass (Da):22,285
Last modified:October 1, 2000 - v1
Checksum:i6975672EF5FD26F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF94680.1
PIRiD82188
RefSeqiNP_231166.1, NC_002505.1
WP_000633519.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF94680; AAF94680; VC_1526
GeneIDi2613905
KEGGivch:VC1526
PATRICifig|243277.26.peg.1454

Similar proteinsi

Entry informationi

Entry nameiMOBA_VIBCH
AccessioniPrimary (citable) accession number: Q9KRV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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