The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q9KQS5 (TIG_VIBCH)
Protein
Trigger factor
Gene
tig
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Functioni
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
By similarityCatalytic activityi
- EC:5.2.1.8
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: GO_Central
- protein folding chaperone Source: GO_Central
- ribosome binding Source: GO_Central
GO - Biological processi
- 'de novo' cotranslational protein folding Source: GO_Central
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- chaperone-mediated protein folding Source: GO_Central
- protein transport Source: UniProtKB-UniRule
- protein unfolding Source: GO_Central
Keywordsi
Molecular function | Chaperone, Isomerase, Rotamase |
Biological process | Cell cycle, Cell division |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tig Ordered Locus Names:VC_1923 |
Organismi | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
Taxonomic identifieri | 243277 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179457 | 1 – 433 | Trigger factorAdd BLAST | 433 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9KQS5 |
SMRi | Q9KQS5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9KQS5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 161 – 246 | PPIase FKBP-typeAdd BLAST | 86 |
Domaini
Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.By similarity
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0544, Bacteria |
HOGENOMi | CLU_033058_2_0_6 |
OMAi | KGIKTQF |
Family and domain databases
Gene3Di | 1.10.3120.10, 1 hit 3.10.50.40, 1 hit 3.30.70.1050, 1 hit |
HAMAPi | MF_00303, Trigger_factor_Tig, 1 hit |
InterProi | View protein in InterPro IPR046357, PPIase_dom_sf IPR001179, PPIase_FKBP_dom IPR005215, Trig_fac IPR008880, Trigger_fac_C IPR037041, Trigger_fac_C_sf IPR008881, Trigger_fac_ribosome-bd_bac IPR036611, Trigger_fac_ribosome-bd_sf IPR027304, Trigger_fact/SurA_dom_sf |
PANTHERi | PTHR30560, PTHR30560, 1 hit |
Pfami | View protein in Pfam PF00254, FKBP_C, 1 hit PF05698, Trigger_C, 1 hit PF05697, Trigger_N, 1 hit |
PIRSFi | PIRSF003095, Trigger_factor, 1 hit |
SUPFAMi | SSF102735, SSF102735, 1 hit SSF109998, SSF109998, 1 hit |
TIGRFAMsi | TIGR00115, tig, 1 hit |
PROSITEi | View protein in PROSITE PS50059, FKBP_PPIASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9KQS5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVTVETLEG LQRRLNITVP AANIEDAVAA ELRNIAKNRR FDGFRKGKVP
60 70 80 90 100
MKMVAKMYGK AVRQDVLGEV MQRHFIEAIV KEKINPAGAP TFAPVEIGEG
110 120 130 140 150
KDLVFTATFE VYPEVELKGL ENIAVEKPAA EVTDADVAEM LETLRKQQAT
160 170 180 190 200
WKEVDEAAEN GKRVSIDFVG SIDGVEFEGG KAENFPLEMG AGRMIPGFED
210 220 230 240 250
GIVGKTKGME FVIDVTFPED YHAENLKGKA AKFAIKVNKV EARELPELND
260 270 280 290 300
EFVARFGVAE GGVDALKAEV RKNMERELKQ AIKARIKEQA IEGLVKENEI
310 320 330 340 350
QVPSALIDQE INVLRQQAAQ RFGGNVEAAA QLPRELFEEQ AKRRVVVGLL
360 370 380 390 400
LGEVIRTHEL KADEEKVKAL ITEMATAYED PSEVVSYYEQ NQQLMNNMRN
410 420 430
VALEEQAVDA IIAKAKVTEK AISFSELMNP VAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003852 Genomic DNA Translation: AAF95071.1 |
PIRi | H82139 |
RefSeqi | NP_231557.1, NC_002505.1 WP_001198446.1, NZ_LT906614.1 |
Genome annotation databases
EnsemblBacteriai | AAF95071; AAF95071; VC_1923 |
GeneIDi | 57740555 |
KEGGi | vch:VC_1923 |
PATRICi | fig|243277.26.peg.1840 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003852 Genomic DNA Translation: AAF95071.1 |
PIRi | H82139 |
RefSeqi | NP_231557.1, NC_002505.1 WP_001198446.1, NZ_LT906614.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T11 | X-ray | 2.50 | A/B | 1-389 | [»] | |
AlphaFoldDBi | Q9KQS5 | |||||
SMRi | Q9KQS5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 243277.VC_1923 |
Protocols and materials databases
DNASUi | 2613552 |
Genome annotation databases
EnsemblBacteriai | AAF95071; AAF95071; VC_1923 |
GeneIDi | 57740555 |
KEGGi | vch:VC_1923 |
PATRICi | fig|243277.26.peg.1840 |
Phylogenomic databases
eggNOGi | COG0544, Bacteria |
HOGENOMi | CLU_033058_2_0_6 |
OMAi | KGIKTQF |
Miscellaneous databases
EvolutionaryTracei | Q9KQS5 |
Family and domain databases
Gene3Di | 1.10.3120.10, 1 hit 3.10.50.40, 1 hit 3.30.70.1050, 1 hit |
HAMAPi | MF_00303, Trigger_factor_Tig, 1 hit |
InterProi | View protein in InterPro IPR046357, PPIase_dom_sf IPR001179, PPIase_FKBP_dom IPR005215, Trig_fac IPR008880, Trigger_fac_C IPR037041, Trigger_fac_C_sf IPR008881, Trigger_fac_ribosome-bd_bac IPR036611, Trigger_fac_ribosome-bd_sf IPR027304, Trigger_fact/SurA_dom_sf |
PANTHERi | PTHR30560, PTHR30560, 1 hit |
Pfami | View protein in Pfam PF00254, FKBP_C, 1 hit PF05698, Trigger_C, 1 hit PF05697, Trigger_N, 1 hit |
PIRSFi | PIRSF003095, Trigger_factor, 1 hit |
SUPFAMi | SSF102735, SSF102735, 1 hit SSF109998, SSF109998, 1 hit |
TIGRFAMsi | TIGR00115, tig, 1 hit |
PROSITEi | View protein in PROSITE PS50059, FKBP_PPIASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TIG_VIBCH | |
Accessioni | Q9KQS5Primary (citable) accession number: Q9KQS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families