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UniProtKB - Q9KQH9 (FABF_VIBCH)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
fabF
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Functioni
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
By similarityCatalytic activityi
- (9Z)-hexadecenoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]By similarityEC:2.3.1.179By similarity
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 164 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: GO_Central
GO - Biological processi
- fatty acid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179By similarity)Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase II Beta-ketoacyl-ACP synthase II Short name: KAS II |
Gene namesi | Name:fabF Ordered Locus Names:VC_2019 |
Organismi | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
Taxonomic identifieri | 243277 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000180327 | 2 – 414 | 3-oxoacyl-[acyl-carrier-protein] synthase 2Add BLAST | 413 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 243277.VC_2019 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9KQH9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_6 |
OMAi | QIGHCLG |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9KQH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKRRVVVTG MGMLSPVGNT VESSWKALLA GQSGIVNIEH FDTTNFSTRF
60 70 80 90 100
AGLVKGFDCE QYMSKKDARK MDLFIQYGIA AGIQALEDSG LEVNEENAAR
110 120 130 140 150
IGVAIGSGIG GLELIETGHQ ALIEKGPRKV SPFFVPSTIV NMIAGNLSIM
160 170 180 190 200
RGLRGPNIAI STACTTGLHN IGHAARMIAY GDADAMVAGG AEKASTPLGM
210 220 230 240 250
AGFGAAKALS TRNDEPQKAS RPWDKDRDGF VLGDGAGIMV LEEYEHAKAR
260 270 280 290 300
GAKIYAEVVG FGMSGDAYHM TSPSEDGSGG ALAMEAAMRD AGVTGEQIGY
310 320 330 340 350
VNAHGTSTPA GDVAEVKGIK RALGEAGTKQ VLVSSTKSMT GHLLGAAGSV
360 370 380 390 400
EAIITVMSLV DQMVPPTINL DNPEEGLGVD LVPHVARKVE SMEYAMCNSF
410
GFGGTNGSLI FKRM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003852 Genomic DNA Translation: AAF95167.1 |
PIRi | D82128 |
RefSeqi | NP_231653.1, NC_002505.1 WP_000044695.1, NZ_LT906614.1 |
Genome annotation databases
EnsemblBacteriai | AAF95167; AAF95167; VC_2019 |
GeneIDi | 57740640 66940449 |
KEGGi | vch:VC2019 |
PATRICi | fig|243277.26.peg.1929 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003852 Genomic DNA Translation: AAF95167.1 |
PIRi | D82128 |
RefSeqi | NP_231653.1, NC_002505.1 WP_000044695.1, NZ_LT906614.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JRH | X-ray | 2.20 | A/B | 1-414 | [»] | |
4JRM | X-ray | 1.75 | A/B/C/D | 1-414 | [»] | |
SMRi | Q9KQH9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 243277.VC_2019 |
Protocols and materials databases
DNASUi | 2613398 |
Genome annotation databases
EnsemblBacteriai | AAF95167; AAF95167; VC_2019 |
GeneIDi | 57740640 66940449 |
KEGGi | vch:VC2019 |
PATRICi | fig|243277.26.peg.1929 |
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_6 |
OMAi | QIGHCLG |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABF_VIBCH | |
Accessioni | Q9KQH9Primary (citable) accession number: Q9KQH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 116 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families