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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Activity regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei785-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei1035-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei193Uracil; via amide nitrogenUniRule annotation1
Binding sitei1995-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • magnesium ion binding Source: UniProtKB-UniRule
  • uracil phosphoribosyltransferase activity Source: TIGR

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2225-MONOMER
UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:VC_2225
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209091 – 208Uracil phosphoribosyltransferaseAdd BLAST208

Proteomic databases

PRIDEiQ9KPY7

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2225

Structurei

3D structure databases

ProteinModelPortaliQ9KPY7
SMRiQ9KPY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 1385-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation9
Regioni198 – 200Uracil bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
KOiK00761
OMAiRICGYEI

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KPY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIVEVKHPL VKHKLGLMRE GDISTKRFRE LATEVASLLT YEATSDFETE
60 70 80 90 100
KVTIEGWNGP VQVDQIKGKK VTVVPILRAG LGMMDGVLEH IPSARISVVG
110 120 130 140 150
IYRDEETLEP VPYFNKLATN IEERIAMVVD PMLAIGGSMI ATIDLLKEKG
160 170 180 190 200
CNQIKVLVLV AAPEGIAALE KAHPDVELYT AAIDEKLNDK GYIVPGLGDA

GDKIFGTK
Length:208
Mass (Da):22,692
Last modified:October 1, 2000 - v1
Checksum:iE2525C4CC58B0386
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF95369.1
PIRiE82103
RefSeqiNP_231856.1, NC_002505.1
WP_010895457.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF95369; AAF95369; VC_2225
GeneIDi2613265
KEGGivch:VC2225
PATRICifig|243277.26.peg.2123

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF95369.1
PIRiE82103
RefSeqiNP_231856.1, NC_002505.1
WP_010895457.1, NC_002505.1

3D structure databases

ProteinModelPortaliQ9KPY7
SMRiQ9KPY7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2225

Proteomic databases

PRIDEiQ9KPY7

Protocols and materials databases

DNASUi2613265
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95369; AAF95369; VC_2225
GeneIDi2613265
KEGGivch:VC2225
PATRICifig|243277.26.peg.2123

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
KOiK00761
OMAiRICGYEI

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00636

BioCyciVCHO:VC2225-MONOMER

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPP_VIBCH
AccessioniPrimary (citable) accession number: Q9KPY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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