UniProtKB - Q9KLD5 (GBPA_VIBCH)
Protein
GlcNAc-binding protein A
Gene
gbpA
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Functioni
Probably interacts with GlcNAc residues. May promote attachment to both epithelial cell surfaces and chitin. This function enhances bacterial colonization in the gastrointestinal tract and may also be important in the environment by augment colonization of chitinous structures, leading to improved survival. Promotes bacterial attachment to, and colonization of, zooplankton in the aquatic ecosystem.1 Publication
GO - Molecular functioni
- chitinase activity Source: TIGR
- chitin binding Source: UniProtKB-UniRule
GO - Biological processi
- chitin catabolic process Source: TIGR
Keywordsi
Ligand | Chitin-binding |
Enzyme and pathway databases
BioCyci | VCHO:VCA0811-MONOMER |
Protein family/group databases
CAZyi | AA10, Auxiliary Activities 10 CBM73, Carbohydrate-Binding Module Family 73 |
Names & Taxonomyi
Protein namesi | Recommended name: GlcNAc-binding protein A |
Gene namesi | Name:gbpA Ordered Locus Names:VC_A0811 |
Organismi | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
Taxonomic identifieri | 243277 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Note: Secreted via the type II secretion pathway EPS (extracellular protein secretion).
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000229723 | 24 – 485 | GlcNAc-binding protein AAdd BLAST | 462 |
Proteomic databases
PRIDEi | Q9KLD5 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9KLD5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 201 | Chitin-binding type-4Add BLAST | 178 | |
Domaini | 437 – 478 | Chitin-binding type-3Add BLAST | 42 |
Sequence similaritiesi
Belongs to the GbpA family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG3397, Bacteria |
HOGENOMi | CLU_039396_2_0_6 |
OMAi | WTFTANH |
Family and domain databases
HAMAPi | MF_01905, GbpA, 1 hit |
InterProi | View protein in InterPro IPR004302, Cellulose/chitin-bd_N IPR041029, GbpA_2 IPR020879, GlcNAc-bd_A IPR014756, Ig_E-set |
Pfami | View protein in Pfam PF18416, GbpA_2, 1 hit PF03067, LPMO_10, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9KLD5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKQPKMTAI ALILSGISGL AYGHGYVSAV ENGVAEGRVT LCKFAANGTG
60 70 80 90 100
EKNTHCGAIQ YEPQSVEGPD GFPVTGPRDG KIASAESALA AALDEQTADR
110 120 130 140 150
WVKRPIQAGP QTFEWTFTAN HVTKDWKYYI TKPNWNPNQP LSRDAFDLNP
160 170 180 190 200
FCVVEGNMVQ PPKRVSHECI VPEREGYQVI LAVWDVGDTA ASFYNVIDVK
210 220 230 240 250
FDGNGPVLPD WNPAGQIIPS MDLSIGDTVY TRVFDNDGEN PAYRTELKID
260 270 280 290 300
SETLTKANQW SYALATKINQ TQKQQRAGQL NGDQFVPVYG TNPIYLKEGS
310 320 330 340 350
GLKSVEIGYQ IEAPQPEYSL TVSGLAKEYE IGEQPIQLDL TLEAQGEMSA
360 370 380 390 400
ELTVYNHHQK PLASWSQAMT DGELKSITLE LSEAKAGHHM LVSRIKDRDG
410 420 430 440 450
NLQDQQTLDF MLVEPQTPPT PGDYDFVFPN GLKEYVAGTK VLASDGAIYQ
460 470 480
CKPWPYSGYC QQWTSNATQY QPGTGSHWEM AWDKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003853 Genomic DNA Translation: AAF96709.1 |
PIRi | A82414 |
RefSeqi | NP_233197.1, NC_002506.1 WP_000744635.1, NZ_LT906615.1 |
Genome annotation databases
EnsemblBacteriai | AAF96709; AAF96709; VC_A0811 |
GeneIDi | 57742190 |
KEGGi | vch:VCA0811 |
PATRICi | fig|243277.26.peg.3431 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE003853 Genomic DNA Translation: AAF96709.1 |
PIRi | A82414 |
RefSeqi | NP_233197.1, NC_002506.1 WP_000744635.1, NZ_LT906615.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2XWX | X-ray | 1.80 | A/B | 24-414 | [»] | |
SMRi | Q9KLD5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 243277.VC_A0811 |
Protein family/group databases
CAZyi | AA10, Auxiliary Activities 10 CBM73, Carbohydrate-Binding Module Family 73 |
Proteomic databases
PRIDEi | Q9KLD5 |
Protocols and materials databases
DNASUi | 2611865 |
Genome annotation databases
EnsemblBacteriai | AAF96709; AAF96709; VC_A0811 |
GeneIDi | 57742190 |
KEGGi | vch:VCA0811 |
PATRICi | fig|243277.26.peg.3431 |
Phylogenomic databases
eggNOGi | COG3397, Bacteria |
HOGENOMi | CLU_039396_2_0_6 |
OMAi | WTFTANH |
Enzyme and pathway databases
BioCyci | VCHO:VCA0811-MONOMER |
Family and domain databases
HAMAPi | MF_01905, GbpA, 1 hit |
InterProi | View protein in InterPro IPR004302, Cellulose/chitin-bd_N IPR041029, GbpA_2 IPR020879, GlcNAc-bd_A IPR014756, Ig_E-set |
Pfami | View protein in Pfam PF18416, GbpA_2, 1 hit PF03067, LPMO_10, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBPA_VIBCH | |
Accessioni | Q9KLD5Primary (citable) accession number: Q9KLD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families