Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 143 (07 Oct 2020)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Add a publicationFeedback
Protein

Beta-galactosidase

Gene

bgaA

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.ARBA annotation EC:3.2.1.23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseARBA annotation, Hydrolase

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM71, Carbohydrate-Binding Module Family 71
GH2, Glycoside Hydrolase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-galactosidaseARBA annotation (EC:3.2.1.23ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bgaAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1313 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wallPROSITE-ProRule annotationARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_50257505152203 – 2233Removed by sortasePROSITE-ProRule annotationAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2202Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchorPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9KGU0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2199 – 2203LPXTG sorting signalPROSITE-ProRule annotation5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.ARBA annotation

Keywords - Domaini

SignalARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 3 hits
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036156, Beta-gal/glucu_dom_sf
IPR011081, Big_4
IPR032311, DUF4982
IPR011098, G5_dom
IPR008979, Galactose-bd-like_sf
IPR040605, Glyco_hydro2_dom5
IPR006101, Glyco_hydro_2
IPR006103, Glyco_hydro_2_cat
IPR006102, Glyco_hydro_2_Ig-like
IPR006104, Glyco_hydro_2_N
IPR017853, Glycoside_hydrolase_SF
IPR019948, Gram-positive_anchor
IPR013783, Ig-like_fold
IPR019931, LPXTG_anchor
IPR005877, YSIRK_signal_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07532, Big_4, 4 hits
PF16355, DUF4982, 1 hit
PF07501, G5, 1 hit
PF18565, Glyco_hydro2_C5, 1 hit
PF00703, Glyco_hydro_2, 1 hit
PF02836, Glyco_hydro_2_C, 1 hit
PF02837, Glyco_hydro_2_N, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF04650, YSIRK_signal, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00132, GLHYDRLASE2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01208, G5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49303, SSF49303, 1 hit
SSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01168, YSIRK_signal, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51109, G5, 1 hit
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9KGU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKGHWNRKR VYSIRKFAVG ACSVMIGTCA VLLGGNIAGE SVVYADETLI
60 70 80 90 100
THTAEKPKEE KMIVEEKADK ALETKNIVER TEQSEPSSTE AIASEKKEDE
110 120 130 140 150
AVTPKEEKVS AKPEEKAPRI ESQASNQEKP LKEDAKAVTN EEVNQMIEDR
160 170 180 190 200
KVDFNQNWYF KLNANSKEAI KPDADVSTWK KLDLPYDWSI FNDFDHESPA
210 220 230 240 250
QNEGGQLNGG EAWYRKTFKL DEKDLKKNVR LTFDGVYMDS QVYVNGQLVG
260 270 280 290 300
HYPNGYNQFS YDITKYLQKD GRENVIAVHA VNKQPSSRWY SGSGIYRDVT
310 320 330 340 350
LQVTDKVHVE KNGTTILTPK LEEQQHGKVE THVTSKIVNT DDKDHELVAE
360 370 380 390 400
YQIVERGGHA VTGLVRTASR TLKAHESTSL DAILEVERPK LWTVLNDKPA
410 420 430 440 450
LYELITRVYR DGQLVDAKKD LFGYRYYHWT PNEGFSLNGE RIKFHGVSLH
460 470 480 490 500
HDHGALGAEE NYKAEYRRLK QMKEMGVNSI RTTHNPASEQ TLQIAAELGL
510 520 530 540 550
LVQEEAFDTW YGGKKPYDYG RFFEKDATHP EARKGEKWSD FDLRTMVERG
560 570 580 590 600
KNNPAIFMWS IGNEIGEANG DAHSLATVKR LVKVIKDVDK TRYVTMGADK
610 620 630 640 650
FRFGNGSGGH EKIADELDAV GFNYSEDNYK ALRAKHPKWL IYGSETSSAT
660 670 680 690 700
RTRGSYYRPE RELKHSNGPE RNYEQSDYGN DRVGWGKTAT ASWTFDRDNA
710 720 730 740 750
GYAGQFIWTG TDYIGEPTPW HNQNQTPVKS SYFGIVDTAG IPKHDFYLYQ
760 770 780 790 800
SQWVSVKKKP MVHLLPHWNW ENKELASKVA DSEGKIPVRA YSNASSVELF
810 820 830 840 850
LNGKSLGLKT FNKKQTSDGR TYQEGANANE LYLEWKVAYQ PGTLEAIARD
860 870 880 890 900
ESGKEIARDK ITTAGKPAAV RLIKEDHAIA ADGKDLTYIY YEIVDSQGNV
910 920 930 940 950
VPTANNLVRF QLHGQGQLVG VDNGEQASRE RYKAQADGSW IRKAFNGKGV
960 970 980 990 1000
AIVKSTEQAG KFTLTAHSDL LKSNQVTVFT GKKEGQEKTV LGTEVPKVQT
1010 1020 1030 1040 1050
IIGEAPEMPT TVPFVYSDGS RAERPVTWSS VDVSKPGIVT VKGMADGREV
1060 1070 1080 1090 1100
EARVEVIALK SELPVVKRIA PNTDLNSVDK SVSYVLIDGS VEEYEVDKWE
1110 1120 1130 1140 1150
IAEEDKAKLA IPGSRIQATG YLEGQPIHAT LVVEEGNPAA PAVPTVTVGG
1160 1170 1180 1190 1200
EAVTGLTSQK PMQYRTLAYG AKLPEVTASA KNAAVTVLQA SAANGMRASI
1210 1220 1230 1240 1250
FIQPKDGGPL QTYAIQFLEE APKIAHLSLQ VEKADSLKED QTVKLSVRAH
1260 1270 1280 1290 1300
YQDGTQAVLP ADKVTFSTSG EGEVAIRKGM LELHKPGAVT LNAEYEGAKD
1310 1320 1330 1340 1350
QVELTIQANT EKKIAQSIRP VNVVTDLHQE PSLPATVTVE YDKGFPKTHK
1360 1370 1380 1390 1400
VTWQAIPKEK LDSYQTFEVL GKVEGIDLEA RAKVSVEGIV SVEEVSVTTP
1410 1420 1430 1440 1450
IAEAPQLPES VRTYDSNGHV SSAKVAWDAI RPEQYAKEGV FTVNGRLEGT
1460 1470 1480 1490 1500
QLTTKLHVRV SAQTEQGANI SDQWTGSELP LAFASDSNPS DPVSNVNDKL
1510 1520 1530 1540 1550
ISYNNQPANR WTNWNRTNPE ASVGVLFGDS GILSKRSVDN LSVGFHEDHG
1560 1570 1580 1590 1600
VGVPKSYVIE YYVGKTVPTA PKNPSFVGNE DHVFNDSANW KPVTNLKAPA
1610 1620 1630 1640 1650
QLKAGEMNHF SFDKVETYAV RIRMVKADNK RGTSITEVQI FAKQVAAAKQ
1660 1670 1680 1690 1700
GQTRIQVDGK DLANFNPDLT DYYLESVDGK VPAVTASVSN NGLATVVPSV
1710 1720 1730 1740 1750
REGEPVRVIA KAENGDILGE YRLHFTKDKS LLSHKPVAAV KQARLLQVGQ
1760 1770 1780 1790 1800
ALELPTKVPV YFTGKDGYET KDLTVEWEEV PAENLTKAGQ FTVRGRVLGS
1810 1820 1830 1840 1850
NLVAEITVRV TDKLGETLSD NPNYDENSNQ AFASATNDID KNSHDRVDYL
1860 1870 1880 1890 1900
NDGDHSENRR WTNWSPTPSS NPEVSAGVIF RENGKIVERT VTQGKVQFFA
1910 1920 1930 1940 1950
DSGTDAPSKL VLERYVGPEF EVPTYYSNYQ AYDADHPFNN PENWEAVPYR
1960 1970 1980 1990 2000
ADKDIAAGDE INVTFKAIKA KAMRWRMERK ADKSGVAMIE MTFLAPSELP
2010 2020 2030 2040 2050
QESTQSKILV DGKELADFAE NRQDYQITYK GQRPKVSVEE NNQVASTVVD
2060 2070 2080 2090 2100
SGEDSFPVLV RLVSESGKQV KEYRIHLTKE KPVSEKTVAA VQEDLPKIEF
2110 2120 2130 2140 2150
VEKDLAYKTV EKKDSTLYLG ETRVEQEGKV GKERIFTAIN PDGSKEEKLR
2160 2170 2180 2190 2200
EVVEVPTDRI VLVGTKPVAQ EAKKPQVSEK ADTKPIDSSE ASQTNKAQLP
2210 2220 2230
STGSAASQAA VAAGLTLLGL SAGLVVTKGK KED
Length:2,233
Mass (Da):247,292
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8170D06584D0A137
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF282987 Genomic DNA Translation: AAF97242.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B95075

NCBI Reference Sequences

More...
RefSeqi
WP_000515174.1, NZ_FYFT01000006.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CVY71244; CVY71244; ERS409372_00336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282987 Genomic DNA Translation: AAF97242.1
PIRiB95075
RefSeqiWP_000515174.1, NZ_FYFT01000006.1

3D structure databases

SMRiQ9KGU0
ModBaseiSearch...

Protein family/group databases

CAZyiCBM71, Carbohydrate-Binding Module Family 71
GH2, Glycoside Hydrolase Family 2

Genome annotation databases

EnsemblBacteriaiCVY71244; CVY71244; ERS409372_00336

Family and domain databases

Gene3Di2.60.120.260, 3 hits
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036156, Beta-gal/glucu_dom_sf
IPR011081, Big_4
IPR032311, DUF4982
IPR011098, G5_dom
IPR008979, Galactose-bd-like_sf
IPR040605, Glyco_hydro2_dom5
IPR006101, Glyco_hydro_2
IPR006103, Glyco_hydro_2_cat
IPR006102, Glyco_hydro_2_Ig-like
IPR006104, Glyco_hydro_2_N
IPR017853, Glycoside_hydrolase_SF
IPR019948, Gram-positive_anchor
IPR013783, Ig-like_fold
IPR019931, LPXTG_anchor
IPR005877, YSIRK_signal_dom
PfamiView protein in Pfam
PF07532, Big_4, 4 hits
PF16355, DUF4982, 1 hit
PF07501, G5, 1 hit
PF18565, Glyco_hydro2_C5, 1 hit
PF00703, Glyco_hydro_2, 1 hit
PF02836, Glyco_hydro_2_C, 1 hit
PF02837, Glyco_hydro_2_N, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF04650, YSIRK_signal, 1 hit
PRINTSiPR00132, GLHYDRLASE2
SMARTiView protein in SMART
SM01208, G5, 1 hit
SUPFAMiSSF49303, SSF49303, 1 hit
SSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit
TIGRFAMsiTIGR01168, YSIRK_signal, 1 hit
PROSITEiView protein in PROSITE
PS51109, G5, 1 hit
PS50847, GRAM_POS_ANCHORING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9KGU0_STREE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9KGU0
Secondary accession number(s): G8JZW7, Q7D4C5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 7, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again