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Entry version 122 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Endo-1,3(4)-beta-glucanase

Gene

BH0236

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.ARBA annotation EC:3.2.1.6

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei853Glucose; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseARBA annotation, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradationARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BHAL272558:G1G3A-269-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM56, Carbohydrate-Binding Module Family 56
CBM6, Carbohydrate-Binding Module Family 6
GH81, Glycoside Hydrolase Family 81

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endo-1,3(4)-beta-glucanaseARBA annotation (EC:3.2.1.6ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:BH0236Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272558 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAlkalihalobacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001258 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02379, Beta-D-Glucose

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500432875026 – 1020Endo-1,3(4)-beta-glucanaseSequence analysisAdd BLAST995

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
272558.10172848

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9KG76

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9KG76

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini796 – 922CBM6InterPro annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni771 – 790DisorderedSequence analysisAdd BLAST20
Regioni863 – 864Glucose bindingCombined sources2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 81 family.ARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG5498, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005482_1_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTYWTGK

Database of Orthologous Groups

More...
OrthoDBi
386120at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006584, Cellulose-bd_IV
IPR005084, CMB_fam6
IPR005200, Endo-beta-glucanase
IPR008979, Galactose-bd-like_sf
IPR040720, GH81_C
IPR040451, GH81_N

The PANTHER Classification System

More...
PANTHERi
PTHR31983, PTHR31983, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03422, CBM_6, 1 hit
PF17652, Glyco_hydro81C, 1 hit
PF03639, Glyco_hydro_81, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00606, CBD_IV, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51175, CBM6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9KG76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGKNVQLLF ALVVIILLFP TGASASPHAV SVGKGSYATE FPEIDFGGIN
60 70 80 90 100
DPGFRDQQGE PPATIYRSDR VTGPMQTNSW WGSLAVDRFS MNQYPHPFSV
110 120 130 140 150
RHRAEGLHVF YDAPHNMVVH ENREAGTWHI HGAIGTDFTI KHSGTANFEQ
160 170 180 190 200
AVVDDYNDWY VRGLLENGAH QMAITYGVGS PYIFVEYEDG SAVLDFDIAP
210 220 230 240 250
DVWEMNGHVI GFSTHDHKHY AAFAPPGQNW SGIGSKTLTN NADYIAIAKL
260 270 280 290 300
PEKDGNMLAK FEQYAYSVVR DAVADWTYDE ATGTVTTTFE VTTEAKVQGA
310 320 330 340 350
PDGTIFALYP HQYRHLASSS ENQLLQNYQY EIIRGTMIGL EGKRFTTELT
360 370 380 390 400
YPGVLPSLPD LGDYDRERLI GYLHDATSDY PTGSDTYELG KYIGKLATLA
410 420 430 440 450
PIADQMGEYE LAEQFRGELK DILEDWLQAT NASGQLKGKN LFYYNENWGT
460 470 480 490 500
ILGYHAAHSS ATRINDHHFH YGYFVKAAAE IARADQEWAK SENWGGMIDL
510 520 530 540 550
LIRDFMADRD DDLFPYLRMF DPYSGNSWAD GLATFDAGNN QESSSEAMHA
560 570 580 590 600
WTNVILWAEA TGNKALRDRA IYLYTTEMSA INEYFFDVHQ EIFPEEYGPE
610 620 630 640 650
IVTINWGGKM DHATWWNSGK VEKYAINWLP FHGGSLYLGH HPDYVDRAYE
660 670 680 690 700
ELRRDIGSTD WNLWSNLVWM YRAFTNPDDA LQQMEASIDD YGLFDPGNEK
710 720 730 740 750
IIERGSTKAQ TYHWIHNLAE LGRVDPTVTA NHPIYAVFNK NGNRTYIVYN
760 770 780 790 800
FSDSPITVQF SDGHSIQVEP HSFNIGNGDG PTNPDPSEPD LKNPYERIQA
810 820 830 840 850
EAYDAMSGIQ TEGTDDDGGG DNIGWINDGD WVKYERVHFE RDASSIEVRV
860 870 880 890 900
ASDTPGGRIE IRTGSPTGTL LGDVQVPNTG GWQQWQTVTG NVQIQPGTYD
910 920 930 940 950
VYLVFKGSPE YDLMNVNWFV FRANGQGNGD SHTHPDYTAG IRGITGNEVT
960 970 980 990 1000
IFFAPTTEAR YVDVHLKVNN GQQLNYRMTE RNGEWERVVE NLSSGDVLEY
1010 1020
SFTYEKLGPQ YTTEWFTYSR
Length:1,020
Mass (Da):114,877
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i456F2D41EFEF1B63
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB03955.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D83679

NCBI Reference Sequences

More...
RefSeqi
WP_010896418.1, NC_002570.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAB03955; BAB03955; BAB03955

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bha:BH0236

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB03955.1
PIRiD83679
RefSeqiWP_010896418.1, NC_002570.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W9SX-ray1.59A/B790-925[»]
1W9TX-ray1.62A/B790-925[»]
1W9WX-ray2.10A790-925[»]
5T49X-ray2.50A28-789[»]
5T4AX-ray2.10A7-7[»]
A28-789[»]
5T4CX-ray1.80A7-7[»]
A28-789[»]
5T4GX-ray1.80A7-7[»]
A28-789[»]
5T7AX-ray1.60A/B926-1020[»]
5UPIX-ray1.65A28-779[»]
5UPMX-ray1.70A28-779[»]
5UPNX-ray1.80A28-779[»]
5UPOX-ray1.70A28-779[»]
5V1WX-ray2.15A28-778[»]
SMRiQ9KG76
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi272558.10172848

Chemistry databases

DrugBankiDB02379, Beta-D-Glucose

Protein family/group databases

CAZyiCBM56, Carbohydrate-Binding Module Family 56
CBM6, Carbohydrate-Binding Module Family 6
GH81, Glycoside Hydrolase Family 81

Genome annotation databases

EnsemblBacteriaiBAB03955; BAB03955; BAB03955
KEGGibha:BH0236

Phylogenomic databases

eggNOGiCOG5498, Bacteria
HOGENOMiCLU_005482_1_0_9
OMAiDTYWTGK
OrthoDBi386120at2

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-269-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ9KG76

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR006584, Cellulose-bd_IV
IPR005084, CMB_fam6
IPR005200, Endo-beta-glucanase
IPR008979, Galactose-bd-like_sf
IPR040720, GH81_C
IPR040451, GH81_N
PANTHERiPTHR31983, PTHR31983, 1 hit
PfamiView protein in Pfam
PF03422, CBM_6, 1 hit
PF17652, Glyco_hydro81C, 1 hit
PF03639, Glyco_hydro_81, 1 hit
SMARTiView protein in SMART
SM00606, CBD_IV, 1 hit
SUPFAMiSSF49785, SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51175, CBM6, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9KG76_BACHD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9KG76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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