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Protein

Cobyric acid synthase

Gene

cobQ

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in the pathway adenosylcobalamin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei333NucleophileUniRule annotation1
Active sitei436UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCobalamin biosynthesis

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-1678-MONOMER
UniPathwayiUPA00148

Names & Taxonomyi

Protein namesi
Recommended name:
Cobyric acid synthaseUniRule annotation
Gene namesi
Name:cobQUniRule annotation
Ordered Locus Names:BH1591
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001412881 – 501Cobyric acid synthaseAdd BLAST501

Proteomic databases

PRIDEiQ9KCI0

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1591

Structurei

3D structure databases

ProteinModelPortaliQ9KCI0
SMRiQ9KCI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini252 – 444GATase cobBQ-typeUniRule annotationAdd BLAST193

Sequence similaritiesi

Belongs to the CobB/CobQ family. CobQ subfamily.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4105CAA Bacteria
COG1492 LUCA
HOGENOMiHOG000224803
KOiK02232
OMAiQVIIHGR
OrthoDBiPOG091H02G3

Family and domain databases

CDDicd01750 GATase1_CobQ, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_00028 CobQ, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017929 CobB/CobQ_GATase
IPR033949 CobQ_GATase1
IPR004459 CobQ_synth
IPR011698 GATase_3
IPR027417 P-loop_NTPase
PANTHERiPTHR21343:SF1 PTHR21343:SF1, 1 hit
PfamiView protein in Pfam
PF07685 GATase_3, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00313 cobQ, 1 hit
PROSITEiView protein in PROSITE
PS51274 GATASE_COBBQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KCI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGIMVQGTA SDVGKSLICT ALCRIFARRG YKVTPFKSQN MSNNSYITVE
60 70 80 90 100
GLEIGRAQGI QAEAAMEEAS VYMNPILLKP RNDREAEIVC FGQAVDTVSG
110 120 130 140 150
VKYRDGFYKR GLEAIKQALA TLSQSFDMVV IEGAGSPVEV NLNDRELVNM
160 170 180 190 200
KVAELADVPV ILVADIERGG VFASLYGTLE LLQPNERKRV VGIIVNKFRG
210 220 230 240 250
DPELFSSGVQ WIEQHLGVPV LGVLPHLPGV RIEGEDSLSK GQVTSVLPRD
260 270 280 290 300
QSIDIAVLDL PYLSNYTDLE PFRYEEDVAI RFVSSVDALG RPDAIILPGT
310 320 330 340 350
KSTFHDLQIL KEKGFKERLH EYVTTDGTVV AICGGFQMLG HRLIDVAGSD
360 370 380 390 400
TGIKGATIDG LDLAPVETRF AEKKKTVRSL GQLLHPFGTA KDIYGFEIHL
410 420 430 440 450
GETDIVDPSI PAFLRVGNHT DGVYLHEGRL IGTYFHHLFF NDDFRSGWLN
460 470 480 490 500
TLRRKKGLRE RPTVELEKCR RASYDQLADE VERVLHVDSL LEKMERWGET

S
Length:501
Mass (Da):55,578
Last modified:October 1, 2000 - v1
Checksum:i98C3C1AF84A6E942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB05310.1
PIRiG83848
RefSeqiWP_010897754.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB05310; BAB05310; BAB05310
KEGGibha:BH1591

Similar proteinsi

Entry informationi

Entry nameiCOBQ_BACHD
AccessioniPrimary (citable) accession number: Q9KCI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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