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Entry version 122 (23 Feb 2022)
Sequence version 2 (13 Apr 2004)
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Protein

Na(+)/H(+) antiporter subunit A

Gene

mrpA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mrp complex is a Na+/H+ antiporter that is considered to be the major Na+ excretion system in B.subtilis. Has a major role in Na+ resistance and a minor role in Na+- and K+-dependent pH homeostasis as compared to TetB. MrpA may be the actual Na+/H+ antiporter, although the six other Mrp proteins are all required for Na+/H+ antiport activity and Na+ resistance. MrpA is required for initiation of sporulation when external Na+ concentration increases. Also transports Li+ but not K+, Ca2+ or Mg2+.

4 Publications

Miscellaneous

Mrp-dependent antiport apparently occurs by a secondary, proton motive force-dependent mechanism, but the similarity of several Mrp proteins to membrane-embedded subunits of energy-coupled NADH dehydrogenase complexes raises the possibility that there is a capacity for electron transport that could provide a primary energy coupling option for Mrp functions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Hydrogen ion transport, Ion transport, Sodium transport, Sporulation, Transport
LigandSodium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU31600-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.63.1.4, the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Na(+)/H(+) antiporter subunit A
Alternative name(s):
Mrp complex subunit A
Multiple resistance and pH homeostasis protein A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrpA
Synonyms:ntrA, shaA, yufT
Ordered Locus Names:BSU31600
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 21HelicalSequence analysisAdd BLAST18
Transmembranei28 – 50HelicalSequence analysisAdd BLAST23
Transmembranei80 – 102HelicalSequence analysisAdd BLAST23
Transmembranei109 – 128HelicalSequence analysisAdd BLAST20
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Transmembranei166 – 188HelicalSequence analysisAdd BLAST23
Transmembranei203 – 222HelicalSequence analysisAdd BLAST20
Transmembranei229 – 251HelicalSequence analysisAdd BLAST23
Transmembranei266 – 288HelicalSequence analysisAdd BLAST23
Transmembranei301 – 323HelicalSequence analysisAdd BLAST23
Transmembranei338 – 360HelicalSequence analysisAdd BLAST23
Transmembranei372 – 394HelicalSequence analysisAdd BLAST23
Transmembranei428 – 450HelicalSequence analysisAdd BLAST23
Transmembranei471 – 493HelicalSequence analysisAdd BLAST23
Transmembranei526 – 548HelicalSequence analysisAdd BLAST23
Transmembranei594 – 616HelicalSequence analysisAdd BLAST23
Transmembranei626 – 647HelicalSequence analysisAdd BLAST22
Transmembranei654 – 671HelicalSequence analysisAdd BLAST18
Transmembranei676 – 698HelicalSequence analysisAdd BLAST23
Transmembranei710 – 732HelicalSequence analysisAdd BLAST23
Transmembranei772 – 789HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002170741 – 801Na(+)/H(+) antiporter subunit AAdd BLAST801

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9K2S2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterooligomeric complex that consists of seven subunits: MrpA, MrpB, MrpC, MrpD, MrpE, MrpF and MrpG.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9K2S2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
224308.BSU31600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9K2S2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1009, Bacteria
COG2111, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9K2S2

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFILQYM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9K2S2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025383, MbhD-like_TM
IPR005663, MrpA/MnhA1/PhaAB
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13244, DUF4040, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00940, 2a6301s01, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9K2S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLLHLAILS PFLFAFIIPF LAKYAKRVHT GWFVLILPVL LFIYFLPMIR
60 70 80 90 100
MTQSGETLRS VLEWIPSLGI NFTVYIDGLG LLFALLITGI GSLVTLYSIF
110 120 130 140 150
YLSKEKEQLG PFYVYLLMFM GAMLGVVLVD NVMVLYMFWE LTSLSSFLLI
160 170 180 190 200
GYWYKREKSR YGAAKSLLIT VSGGLCMLGG FILLYLITDS FSIREMVHQV
210 220 230 240 250
QLIAGHELFI PAMILILLGA FTKSAQFPFY IWLPDAMEAP TPVSAYLHSA
260 270 280 290 300
TMVKAGIYVI ARFSPIFAFS AQWFWIVSLV GLFTMVWGSF HAVKQTDLKS
310 320 330 340 350
ILAFSTVSQL GMIISMLGVS AAALHYGHTE YYTVAAMAAI FHLINHATFK
360 370 380 390 400
GSLFMAVGII DHETGTRDIR KLGGLMAIMP ITFTISLIGT FSMAGLPPFN
410 420 430 440 450
GFLSKEMFFT SMLRVTHFDL FNVQTWGVLF PLFAWIGSVF TFIYSMKLLF
460 470 480 490 500
KTFRGNYQPE QLEKQAHEAP VGMLVPPVIL VALAVSLFFF PNILSYSLIE
510 520 530 540 550
PAMNSIYPTL LDGHEKFHVH ISQWHGVTTE LLMTAGIVVI GTIGYLSLNK
560 570 580 590 600
WKGIYKLFPS KLTLNRLYDK LLTMMEKGSY RVTKQYMTGF LRDYLLYIFA
610 620 630 640 650
GFIILIGGAF AIKGGFSFKT EGMAKIGVYE IILTLVMISA TVATVFARSR
660 670 680 690 700
LTAIIALGVV GYTLALFFVI FRAPDLALTQ LVIETISVAL FLLCFYHLPK
710 720 730 740 750
LRLKTKTRTF RMTNFIISLG VGVIVTLLGI ASSSQRTKDS IASFFVKHSH
760 770 780 790 800
DLGGGDNVVN VILVDFRGFD TMFEITVLTI AALGIYSMIK TKVKEEGKSG

E
Length:801
Mass (Da):89,531
Last modified:April 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6DE22B56DAA725D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB07942 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z93937 Genomic DNA Translation: CAB07942.1 Different initiation.
AL009126 Genomic DNA Translation: CAB15149.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A70010

NCBI Reference Sequences

More...
RefSeqi
NP_391038.2, NC_000964.3
WP_003228821.1, NZ_JNCM01000033.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB15149; CAB15149; BSU_31600

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
938828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU31600

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.3425

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93937 Genomic DNA Translation: CAB07942.1 Different initiation.
AL009126 Genomic DNA Translation: CAB15149.2
PIRiA70010
RefSeqiNP_391038.2, NC_000964.3
WP_003228821.1, NZ_JNCM01000033.1

3D structure databases

SMRiQ9K2S2
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9K2S2, 1 interactor
STRINGi224308.BSU31600

Protein family/group databases

TCDBi2.A.63.1.4, the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family

Proteomic databases

PaxDbiQ9K2S2

Genome annotation databases

EnsemblBacteriaiCAB15149; CAB15149; BSU_31600
GeneIDi938828
KEGGibsu:BSU31600
PATRICifig|224308.179.peg.3425

Phylogenomic databases

eggNOGiCOG1009, Bacteria
COG2111, Bacteria
InParanoidiQ9K2S2
OMAiAFILQYM
PhylomeDBiQ9K2S2

Enzyme and pathway databases

BioCyciBSUB:BSU31600-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR025383, MbhD-like_TM
IPR005663, MrpA/MnhA1/PhaAB
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N
PfamiView protein in Pfam
PF13244, DUF4040, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit
TIGRFAMsiTIGR00940, 2a6301s01, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRPA_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9K2S2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 23, 2022
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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