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Entry version 101 (16 Jan 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Transferrin-binding protein 1

Gene

tbp1

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transferrin receptor and is required for transferrin utilization.By similarity

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
NMEN122586:G1G1B-455-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transferrin-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tbp1
Ordered Locus Names:NMB0461
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria meningitidis serogroup B (strain MC58)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri122586 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000425 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24By similarityAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034988925 – 915Transferrin-binding protein 1Add BLAST891

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9K0U9

PRoteomics IDEntifications database

More...
PRIDEi
Q9K0U9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TFP027874EBI-15968954,EBI-714319From Homo sapiens.

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-59653N

Protein interaction database and analysis system

More...
IntActi
Q9K0U9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
122586.NMB0461

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1915
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V89X-ray3.10A25-915[»]
3V8XX-ray2.60A25-915[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9K0U9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9K0U9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi38 – 45TonB box8
Motifi898 – 915TonB C-terminal boxAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108MVK Bacteria
COG1629 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000219090

KEGG Orthology (KO)

More...
KOi
K16087

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSFAEMY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR039423 TonB-dep_rcpt
IPR000531 TonB-dep_rcpt_b-brl
IPR010916 TonB_box_CS
IPR010949 TonB_Hb/transfer/lactofer_rcpt
IPR010948 TonB_lacto/transferrin_rcpt
IPR010917 TonB_rcpt_CS

The PANTHER Classification System

More...
PANTHERi
PTHR32552 PTHR32552, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01786 TonB-hemlactrns, 1 hit
TIGR01776 TonB-tbp-lbp, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit
PS01156 TONB_DEPENDENT_REC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9K0U9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQQHLFRFN ILCLSLMTAL PAYAENVQAG QAQEKQLDTI QVKAKKQKTR
60 70 80 90 100
RDNEVTGLGK LVKSSDTLSK EQVLNIRDLT RYDPGIAVVE QGRGASSGYS
110 120 130 140 150
IRGMDKNRVS LTVDGVSQIQ SYTAQAALGG TRTAGSSGAI NEIEYENVKA
160 170 180 190 200
VEISKGSNSV EQGSGALAGS VAFQTKTADD VIGEGRQWGI QSKTAYSGKN
210 220 230 240 250
RGLTQSIALA GRIGGAEALL IHTGRRAGEI RAHEDAGRGV QSFNRLVPVE
260 270 280 290 300
DSSNYAYFIV KEECKNGSYE TCKANPKKDV VGKDERQTVS TRDYTGPNRF
310 320 330 340 350
LADPLSYESR SWLFRPGFRF ENKRHYIGGI LEHTQQTFDT RDMTVPAFLT
360 370 380 390 400
KAVFDANKKQ AGSLPGNGKY AGNHKYGGLF TNGENGALVG AEYGTGVFYD
410 420 430 440 450
ETHTKSRYGL EYVYTNADKD TWADYARLSY DRQGIGLDNH FQQTHCSADG
460 470 480 490 500
SDKYCRPSAD KPFSYYKSDR VIYGESHRLL QAAFKKSFDT AKIRHNLSVN
510 520 530 540 550
LGFDRFGSNL RHQDYYYQHA NRAYSSNTPP QNNGKKISPN GSETSPYWVT
560 570 580 590 600
IGRGNVVTGQ ICRLGNNTYT DCTPRSINGK SYYAAVRDNV RLGRWADVGA
610 620 630 640 650
GLRYDYRSTH SDDGSVSTGT HRTLSWNAGI VLKPTDWLDL TYRTSTGFRL
660 670 680 690 700
PSFAEMYGWR AGVQSKAVKI DPEKSFNKEA GIVFKGDFGN LEASWFNNAY
710 720 730 740 750
RDLIVRGYEA QIKDGKEEAK GDPAYLNAQS ARITGINILG KIDWNGVWDK
760 770 780 790 800
LPEGWYSTFA YNRVRVRDIK KRADRTDIQS HLFDAIQPSR YVVGLGYDQP
810 820 830 840 850
EGKWGVNGML TYSKAKEITE LLGSRALLNG NSRNTKATAR RTRPWYIVDV
860 870 880 890 900
SGYYTVKKHF TLRAGVYNLL NYRYVTWENV RQTAGGAVNQ HKNVGVYNRY
910
AAPGRNYTFS LEMKF
Length:915
Mass (Da):102,107
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i110A3F38A59287D5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF40898.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F81196

NCBI Reference Sequences

More...
RefSeqi
NP_273508.1, NC_003112.2
WP_010980797.1, NC_003112.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAF40898; AAF40898; NMB0461

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
902577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nme:NMB0461

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|122586.8.peg.601

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF40898.1
PIRiF81196
RefSeqiNP_273508.1, NC_003112.2
WP_010980797.1, NC_003112.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V89X-ray3.10A25-915[»]
3V8XX-ray2.60A25-915[»]
ProteinModelPortaliQ9K0U9
SMRiQ9K0U9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59653N
IntActiQ9K0U9, 2 interactors
STRINGi122586.NMB0461

Proteomic databases

PaxDbiQ9K0U9
PRIDEiQ9K0U9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF40898; AAF40898; NMB0461
GeneIDi902577
KEGGinme:NMB0461
PATRICifig|122586.8.peg.601

Phylogenomic databases

eggNOGiENOG4108MVK Bacteria
COG1629 LUCA
HOGENOMiHOG000219090
KOiK16087
OMAiPSFAEMY

Enzyme and pathway databases

BioCyciNMEN122586:G1G1B-455-MONOMER

Family and domain databases

Gene3Di2.170.130.10, 1 hit
InterProiView protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR039423 TonB-dep_rcpt
IPR000531 TonB-dep_rcpt_b-brl
IPR010916 TonB_box_CS
IPR010949 TonB_Hb/transfer/lactofer_rcpt
IPR010948 TonB_lacto/transferrin_rcpt
IPR010917 TonB_rcpt_CS
PANTHERiPTHR32552 PTHR32552, 1 hit
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit
TIGRFAMsiTIGR01786 TonB-hemlactrns, 1 hit
TIGR01776 TonB-tbp-lbp, 1 hit
PROSITEiView protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit
PS01156 TONB_DEPENDENT_REC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBP1_NEIMB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9K0U9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2000
Last modified: January 16, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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