Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Na(+)-translocating NADH-quinone reductase subunit C

Gene

nqrC

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.UniRule annotation

Caution

The residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr.UniRule annotationCurated

Catalytic activityi

NADH + ubiquinone + n Na+(In) = NAD+ + ubiquinol + n Na+(Out).UniRule annotation

Cofactori

FMNUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIon transport, Sodium transport, Transport
LigandFlavoprotein, FMN, NAD, Sodium, Ubiquinone

Enzyme and pathway databases

BioCyciNMEN122586:G1G1B-552-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit CUniRule annotation (EC:1.6.5.8UniRule annotation)
Short name:
Na(+)-NQR subunit CUniRule annotation
Short name:
Na(+)-translocating NQR subunit CUniRule annotation
Alternative name(s):
NQR complex subunit CUniRule annotation
NQR-1 subunit CUniRule annotation
Gene namesi
Name:nqrCUniRule annotation
Ordered Locus Names:NMB0567
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002142181 – 258Na(+)-translocating NADH-quinone reductase subunit CAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226FMN phosphoryl serineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9K0M5
PRIDEiQ9K0M5

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.UniRule annotation

Protein-protein interaction databases

STRINGi122586.NMB0567

Structurei

3D structure databases

SMRiQ9K0M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NqrC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106I92 Bacteria
COG2869 LUCA
HOGENOMiHOG000273678
KOiK00348
OMAiGLWDAIW
OrthoDBiPOG091H069G

Family and domain databases

HAMAPiMF_00427 NqrC, 1 hit
InterProiView protein in InterPro
IPR007329 FMN-bd
IPR010204 NqrC
PANTHERiPTHR37838 PTHR37838, 1 hit
PfamiView protein in Pfam
PF04205 FMN_bind, 1 hit
PIRSFiPIRSF009437 NQR-1_subunit_C, 1 hit
SMARTiView protein in SMART
SM00900 FMN_bind, 1 hit
TIGRFAMsiTIGR01938 nqrC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K0M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKFDKDSF SGTLIVVLAV SLICSVIVAG AVVGLKPIQE KQKLQDKQGY
60 70 80 90 100
ILSVAGLMDK DTDIGKTFAE RIEQRVVDLA TGEYVADAPK DFSARIAGKD
110 120 130 140 150
PAQSIRIKTE DDLAGIKSRA KYTEVYLVKG EDGKIGQIIL PMHGNGLWSV
160 170 180 190 200
MYGFVAIQPD GNTINGITYY EQGETPGLGG EIGNPLWQQK FVGKKLFDGQ
210 220 230 240 250
GKLALHVGKG AGSDKEHGVD ALSGASLTSK GVQGSFAYWF GENGYIPYLN

KLKSAGAQ
Length:258
Mass (Da):27,607
Last modified:October 1, 2000 - v1
Checksum:i1F20D8EF011F7C3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA Translation: AAF40995.1
PIRiB81185
RefSeqiNP_273611.1, NC_003112.2
WP_002225563.1, NC_003112.2

Genome annotation databases

EnsemblBacteriaiAAF40995; AAF40995; NMB0567
GeneIDi902682
KEGGinme:NMB0567
PATRICifig|122586.8.peg.726

Similar proteinsi

Entry informationi

Entry nameiNQRC_NEIMB
AccessioniPrimary (citable) accession number: Q9K0M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health